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Chemical Compound Review

Timunox     3-[[6-amino-2-[[2-amino-5...

Synonyms: THYMOPENTIN, Timopentina, Thymopentine, Thymopentinum, TP-5, ...
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Disease relevance of THYMOPENTIN


Psychiatry related information on THYMOPENTIN


High impact information on THYMOPENTIN


Chemical compound and disease context of THYMOPENTIN


Biological context of THYMOPENTIN


Anatomical context of THYMOPENTIN

  • Thus thymopoietin and thymopentin affect neuromuscular transmission and induce the phenotypic differentiation of T precursor cells in vitro while inhibiting phenotypic differentiation of B cells [9].
  • Therapy with biologic response modifiers, such as interferon gamma or thymopentin, is oriented toward normalization of imbalanced immune responsiveness, rather than direct suppression of the immune system [19].
  • He showed a marked increase in large granular lymphocytes (LGL) both during the treatment with TP-5 and after BMT [17].
  • A boy with combined immunodeficiency having low natural killer (NK)-cell activity received thymopoietin pentapeptide (TP-5) treatment, transplanted with T cell-depleted HLA-haploidentical bone marrow (BMT) cells from his father and with thymus tissue from an infant at different times during the first year of life [17].
  • We identified monocytes and neutrophils as TP5-binding cells by displacing fluorescein-labelled TP5 with an excess of unlabelled TP5 in competition assays [20].

Associations of THYMOPENTIN with other chemical compounds


Gene context of THYMOPENTIN

  • The thymopentin-treated mice produce enhanced levels of IL-2 and IFN-gamma, but significantly reduced amounts of IL-4 [25].
  • The effects of thymopentin on the development of SLE-like syndrome in the MRL/lpr-lpr mouse [26].
  • Immune imbalance in the synovial fluid of rheumatoid arthritis patients: effects of intra-articular injection of thymopentin [27].
  • On the basis of these results, an intra-articular immunomodulating treatment with thymopentin has been performed: its effects were characterized by an increase of CD8+CD11b+ T cells in the CD8 subset parallel to the enhancement of the suppressor-inducer/naive T cells in the CD4 subset with a statistically significant correlation [27].
  • The examination of immunomodulatory properties of oligopeptides derived from two exposed loops (containing thymopentin-like and tuftsin-like sequences, respectively) of the proteins belonging to TGF beta family suggests that the particular species of the TGF beta family should differ distinctly in their influence on the immune response [28].

Analytical, diagnostic and therapeutic context of THYMOPENTIN


  1. Thymopentin in Sézary syndrome. Bernengo, M.G., Appino, A., Bertero, M., Novelli, M., Fierro, M.T., Doveil, G.C., Lisa, F. J. Natl. Cancer Inst. (1992) [Pubmed]
  2. Thymopentin as adjuvant in non-responders or hyporesponders to hepatitis B vaccination. Záruba, K., Rastorfer, M., Grob, P.J., Joller-Jemelka, H., Bolla, K. Lancet (1983) [Pubmed]
  3. Response to thymopoietin pentapeptide in patient with DiGeorge syndrome. Aiuti, F., Businco, L., Rossi, P., Quinti, I. Lancet (1980) [Pubmed]
  4. Treatment of active rheumatoid arthritis with slow intravenous injections of thymopentin. A double-blind placebo-controlled randomised study. Malaise, M.G., Hauwaert, C., Franchimont, P., Danneskiold-Samsoe, B., Bach-Andersen, R., Gross, D., Gerber, H., Gerschpacher, H., Stocker, H., Bolla, K. Lancet (1985) [Pubmed]
  5. Thymopoietin pentapeptide treatment of primary immunodeficiencies. Aiuti, F., Businco, L., Fiorilli, M., Galli, E., Quinti, I., Rossi, P., Seminara, R., Goldstein, G. Lancet (1983) [Pubmed]
  6. Administration of thymopentin to patients with phobic disorders improves depressed phagocytic functions. Covelli, V., Munno, I., Altamura, M., Pellegrino, N.M., Decandia, P., Jirillo, E. Immunopharmacology and immunotoxicology. (1990) [Pubmed]
  7. T cell development in normal and thymopentin-treated nude mice. Ranges, G.E., Goldstein, G., Boyse, E.A., Schield, M.P. J. Exp. Med. (1982) [Pubmed]
  8. Immunotherapy of human immunodeficiency virus infection. Hadden, J.W. Trends Pharmacol. Sci. (1991) [Pubmed]
  9. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Audhya, T., Scheid, M.P., Goldstein, G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  10. The prognostic significance of serum viral load, codon 215 reverse transcriptase mutation and CD4+ T cells on progression of HIV disease in a double-blind study of thymopentin. Merigan, T.C., Hirsch, R.L., Fisher, A.C., Meyerson, L.A., Goldstein, G., Winters, M.A. AIDS (1996) [Pubmed]
  11. Sequential biochemotherapy for metastatic colorectal cancer using fluorouracil, folinic acid, thymopentin and interleukin-2: clinical and immunological effects. Lopez, M., Di Lauro, L., Paoletti, G., Santini, S., Gandolfo, G.M., Vitelli, G., Frasca, A.M., Ameglio, F., Rasi, G., Garaci, E. Ann. Oncol. (1995) [Pubmed]
  12. Use of subcutaneous thymopentin in the treatment of steroid-dependent relapsing minimal-change nephrotic syndrome. Cheng, I.K., Jones, B.M. Nephron (1993) [Pubmed]
  13. Immunomodulators in the treatment of cutaneous lymphoma. Rogalski, C., Dummer, R., Burg, G. Journal of the European Academy of Dermatology and Venereology : JEADV. (1999) [Pubmed]
  14. CD10 is expressed on human thymic epithelial cell lines and modulates thymopentin-induced cell proliferation. Guérin, S., Mari, B., Fernandez, E., Belhacene, N., Toribio, M.L., Auberger, P. FASEB J. (1997) [Pubmed]
  15. Effect of thymopoietin pentapeptide (TP5) on autoimmunity. I. TP5 suppression of induced erythrocyte autoantibodies in C3H mice. Lau, C.Y., Freestone, J.A., Goldstein, G. J. Immunol. (1980) [Pubmed]
  16. Immunomodulatory therapy with thymopentin and indomethacin. Successful restoration of interleukin-2 synthesis in patients undergoing major surgery. Faist, E., Markewitz, A., Fuchs, D., Lang, S., Zarius, S., Schildberg, F.W., Wachter, H., Reichart, B. Ann. Surg. (1991) [Pubmed]
  17. Phenotypical and functional heterogeneity of the large granular lymphocytes increased after various treatments in a patient with combined immunodeficiency. Takagi, S., Minakuchi, J., Okawa, H., Yata, J. J. Clin. Immunol. (1989) [Pubmed]
  18. Cooperativity of thymopoietin 32-36 (the active site) and thymopoietin 38-45 in receptor binding. Audhya, T., Heavner, G.A., Kroon, D.J., Goldstein, G. Regul. Pept. (1984) [Pubmed]
  19. Atopic dermatitis: recent trends in pathogenesis and therapy. Cooper, K.D. J. Invest. Dermatol. (1994) [Pubmed]
  20. TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes. Gonser, S., Crompton, N.E., Weber, P.J., Beck-Sickinger, A.G., Folkers, G. J. Recept. Signal Transduct. Res. (1999) [Pubmed]
  21. Contrasting effects of thymopentin and splenopentin on the capacity of female mice to reject syngeneic male skin. Goldberg, E.H., Goldstein, G., Harman, D.B., Boyse, E.A. Transplantation (1984) [Pubmed]
  22. Enhancement of antitumor effects of combined chemoimmunotherapy. Taylor, D.D., Gerçel-Taylor, C., Fowler, W.C., Weese, J.L. J. Immunother. (1993) [Pubmed]
  23. Successful restoration of cell-mediated immune response after cardiopulmonary bypass by immunomodulation. Markewitz, A., Faist, E., Lang, S., Endres, S., Fuchs, D., Reichart, B. J. Thorac. Cardiovasc. Surg. (1993) [Pubmed]
  24. Antibodies to thymopoietin following implantation of paper disks derivatized with synthetic Cys-thymopoietin. Viamontes, G.I., Audhya, T., Goldstein, G. J. Immunol. Methods (1986) [Pubmed]
  25. Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets. Cillari, E., Milano, S., Dieli, M., Arcoleo, F., Perego, R., Leoni, F., Gromo, G., Severn, A., Liew, F.Y. Immunology (1992) [Pubmed]
  26. The effects of thymopentin on the development of SLE-like syndrome in the MRL/lpr-lpr mouse. Nicoletti, F., Zaccone, P., Magro, G., Barcellini, W., Cavallaro, V., Belli, G., Cocuzza, C., di Marco, R., Meroni, P.L. Scand. J. Immunol. (1994) [Pubmed]
  27. Immune imbalance in the synovial fluid of rheumatoid arthritis patients: effects of intra-articular injection of thymopentin. Afeltra, A., Galeazzi, M., Basso, P., Pietrucci, A., De Pità, O., Ferri, G.M., Porzio, F., Bonomo, L. J. Biol. Regul. Homeost. Agents (1991) [Pubmed]
  28. The immunomodulatory diversity of the proteins of the transforming growth factor beta (TGF beta) family. Wieczorek, Z., Słoń, J., Kluczyk, A., Zbozień, R., Stafanowicz, P., Siemion, I.Z. Int. J. Pept. Protein Res. (1995) [Pubmed]
  29. Production and characterization of a bovine T cell-specific monoclonal antibody identifying a mature differentiation antigen. Rabinovsky, E.D., Yang, T.J. J. Immunol. (1986) [Pubmed]
  30. Thymopentin therapy reduces the clinical severity of atopic dermatitis. Leung, D.Y., Hirsch, R.L., Schneider, L., Moody, C., Takaoka, R., Li, S.H., Meyerson, L.A., Mariam, S.G., Goldstein, G., Hanifin, J.M. J. Allergy Clin. Immunol. (1990) [Pubmed]
  31. Regulatory influence of thymopentin on splenic T cell sets of thymectomized and aged mice. Newcomb, E.W., Goldberg, E.H., de Sousa, M., Goldstein, G., Boyse, E.A., Scheid, M.P. Transplantation (1985) [Pubmed]
  32. Impact of thymopentin on the incidence and severity of postoperative infection: a randomized controlled trial. Braga, M., Costantini, E., Di Francesco, A., Gianotti, L., Baccari, P., Di Carlo, V. The British journal of surgery. (1994) [Pubmed]
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