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Chemical Compound Review:

Toxin 6 3-(bis(2-bromoethyl)amino)-1- (4...

Synonyms: AC1L2QNI, 142058-13-7

Holds, J.B. et al., Garzón, J. et al., Parolaro, D. et al., Dimmler, A. et al., Ziprin, R.L. et al.

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Disease relevance of Toxin 6

Examination of orbicularis muscle from 10 patients with essential blepharospasm who received 2-18 injections of botulinum toxin 6 weeks to 3 years prior to surgery revealed characteristic nodal, terminal and ultraterminal "sprouting" of the motor axons [1].
The pertussis toxin-catalyzed ADP ribosylation of a 39-41 kDa substrate in membranes prepared from hypothalamus and midbrain of rats injected with toxin 6 days before was strongly reduced as compared to the controls [2].
1. GN was introduced in male Sprague-Dawley rats (1.0 mg/kg body weight of OX-7 IV) and Habu Snake Venom GN was introduced in C57BL6 mice (habu snake venom toxin 6 mg/kg body weight IV) [3].
Mice were also treated with T-2 toxin 6 days before vaccination with Mycobacterium bovis (BCG) [4].

High impact information on Toxin 6

The intrathecal injection of 1 micrograms pertussis toxin 6 days before sacrifice of rats produced in these arthritic animals a pronounced reduction of ir-SP in the pons-medulla, midbrain and thalamus, but not in the spinal cord [5].

References

Motor nerve sprouting in human orbicularis muscle after botulinum A injection. Holds, J.B., Alderson, K., Fogg, S.G., Anderson, R.L. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
Pertussis toxin modifies the effect of central morphine on rat intestinal motility. Parolaro, D., Patrini, G., Massi, P., Parenti, M., Rubino, T., Giagnoni, G., Gori, E. Eur. J. Pharmacol. (1990) [Pubmed]
Laser capture microdissection and real-time PCR for analysis of glomerular endothelin-1 gene expression in mesangiolysis of rat anti-Thy 1.1 and murine Habu Snake Venom glomerulonephritis. Dimmler, A., Haas, C.S., Cho, S., Hattler, M., Forster, C., Peters, H., Schöcklmann, H.O., Amann, K. Diagn. Mol. Pathol. (2003) [Pubmed]
Influence of T-2 toxin on BCG vaccine efficacy against murine pulmonary tuberculosis. Ziprin, R.L., McMurray, D.N. Veterinary and human toxicology. (1989) [Pubmed]
Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats. Garzón, J., Lérida, M., Sánchez-Blázquez, P. Life Sci. (1990) [Pubmed]

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