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Chemical Compound Review

Fasidotril     benzyl(2S)-2-[[(2S)-3- benzo[1,3]dioxol-5...

Synonyms: AC1L2ZWT, DNC000639, 135038-57-2, UNII-BIB7HG2V9E, 99544-EP2270011A1, ...
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Disease relevance of Fasidotril


High impact information on Fasidotril


Gene context of Fasidotril

  • Fasidotril is a related compound which has special interest as an equipotent dual inhibitor of NEP and ACE (EC [6].

Analytical, diagnostic and therapeutic context of Fasidotril

  • Twenty-four hours after ligation, 172 rats were assigned to either placebo or fasidotril therapy (180 mg/kg/day, orally) for 40 weeks [1].


  1. Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction. Marie, C., Mossiat, C., Gros, C., Schwartz, J.C., Lecomte, J.M., Bralet, J. Cardiovasc. Res. (1999) [Pubmed]
  2. Fasidotril Eli Lilly. Ozdener, F., Ozdemir, V. Current opinion in investigational drugs (London, England : 2000) (2003) [Pubmed]
  3. Mixed inhibitors of angiotensin-converting enzyme (EC and enkephalinase (EC rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. Gros, C., Noël, N., Souque, A., Schwartz, J.C., Danvy, D., Plaquevent, J.C., Duhamel, L., Duhamel, P., Lecomte, J.M., Bralet, J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril. Bralet, J., Marie, C., Mossiat, C., Lecomte, J.M., Gros, C., Schwartz, J.C. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  5. Cardiorenal consequences of dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibition in transgenic rats with an extra renin gene. Wegner, M., Hirth-Dietrich, C., Knorr, A., Dressel, J., Ganten, D., Stasch, J.P. Hypertens. Res. (1996) [Pubmed]
  6. Strategies for access to enantiomerically pure ecadotril, dexecadotril and fasidotril: a review. Monteil, T., Danvy, D., Sihel, M., Leroux, R., Plaquevent, J.C. Mini reviews in medicinal chemistry. (2002) [Pubmed]
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