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Gene Review

Sysbp1  -  systolic blood pressure 1

Mus musculus

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Disease relevance of Sysbp1


Psychiatry related information on Sysbp1


High impact information on Sysbp1


Chemical compound and disease context of Sysbp1


Biological context of Sysbp1


Anatomical context of Sysbp1

  • The systolic blood pressure (mmHg), measured by carotid artery cannulation at 10-12 weeks of age, was higher in tTA+/RVCH+ mice than in nonbinary transgenic littermates (136 +/- 4 vs. 109 +/- 3) (P < 0.05), as were the diastolic and mean pressures [21].
  • Systolic blood pressure, however, was modulated by fasting and refeeding in a manner parallel to adipocyte angiotensinogen expression [22].
  • Systolic blood pressure (SBP) was measured by tail-cuff methodology and function and structure of small mesenteric arteries were studied in pressurized vessels [23].
  • Aortic sinus lesions were more severe in apoE(-/-)/bGH mice fed standard diet compared with littermate apoE(-/-) mice. apoE(-/-)/bGH mice had lower (VLDL+LDL)/HDL ratios compared with littermate apoE(-/-) mice, while systolic blood pressure was higher in apoE(-/-)/bGH mice, irrespective of diet [24].
  • The present study was undertaken to characterize insulin-stimulated skeletal muscle glucose transport in male heterozygous TG(mREN2)27 rats and to evaluate the effect of voluntary exercise training on SBP and skeletal muscle glucose transport [25].

Associations of Sysbp1 with chemical compounds


Regulatory relationships of Sysbp1

  • AT1A receptor deficiency-induced reductions in atherosclerosis were independent of systolic blood pressure and measurements of oxidation and chemoattractants [30].

Other interactions of Sysbp1


Analytical, diagnostic and therapeutic context of Sysbp1


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  2. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. Sugaya, T., Nishimatsu, S., Tanimoto, K., Takimoto, E., Yamagishi, T., Imamura, K., Goto, S., Imaizumi, K., Hisada, Y., Otsuka, A. J. Biol. Chem. (1995) [Pubmed]
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  9. The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure. Stock, J.L., Shinjo, K., Burkhardt, J., Roach, M., Taniguchi, K., Ishikawa, T., Kim, H.S., Flannery, P.J., Coffman, T.M., McNeish, J.D., Audoly, L.P. J. Clin. Invest. (2001) [Pubmed]
  10. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. Asico, L.D., Ladines, C., Fuchs, S., Accili, D., Carey, R.M., Semeraro, C., Pocchiari, F., Felder, R.A., Eisner, G.M., Jose, P.A. J. Clin. Invest. (1998) [Pubmed]
  11. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. Albrecht, F.E., Drago, J., Felder, R.A., Printz, M.P., Eisner, G.M., Robillard, J.E., Sibley, D.R., Westphal, H.J., Jose, P.A. J. Clin. Invest. (1996) [Pubmed]
  12. Regulatable atrial natriuretic peptide gene therapy for hypertension. Schillinger, K.J., Tsai, S.Y., Taffet, G.E., Reddy, A.K., Marian, A.J., Entman, M.L., Oka, K., Chan, L., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Blood pressure responses to acute or chronic captopril in mice with disruption of bradykinin B2-receptor gene. Emanueli, C., Angioni, G.R., Anania, V., Spissu, A., Madeddu, P. J. Hypertens. (1997) [Pubmed]
  14. Hemodynamic changes in apolipoprotein E-knockout mice. Hartley, C.J., Reddy, A.K., Madala, S., Martin-McNulty, B., Vergona, R., Sullivan, M.E., Halks-Miller, M., Taffet, G.E., Michael, L.H., Entman, M.L., Wang, Y.X. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  15. A novel thromboxane receptor antagonist and synthase inhibitor, BM-573, reduces development and progression of atherosclerosis in LDL receptor deficient mice. Cyrus, T., Yao, Y., Ding, T., Dogné, J.M., Praticò, D. Eur. J. Pharmacol. (2007) [Pubmed]
  16. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Huentelman, M.J., Grobe, J.L., Vazquez, J., Stewart, J.M., Mecca, A.P., Katovich, M.J., Ferrario, C.M., Raizada, M.K. Exp. Physiol. (2005) [Pubmed]
  17. Genome scan for blood pressure loci in mice. Wright, F.A., O'Connor, D.T., Roberts, E., Kutey, G., Berry, C.C., Yoneda, L.U., Timberlake, D., Schlager, G. Hypertension (1999) [Pubmed]
  18. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Paradis, P., Dali-Youcef, N., Paradis, F.W., Thibault, G., Nemer, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes. Ohkubo, H., Kawakami, H., Kakehi, Y., Takumi, T., Arai, H., Yokota, Y., Iwai, M., Tanabe, Y., Masu, M., Hata, J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  20. Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Quan, H., Athirakul, K., Wetsel, W.C., Torres, G.E., Stevens, R., Chen, Y.T., Coffman, T.M., Caron, M.G. Mol. Cell. Biol. (2004) [Pubmed]
  21. Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice. Ju, H., Gros, R., You, X., Tsang, S., Husain, M., Rabinovitch, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  22. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Frederich, R.C., Kahn, B.B., Peach, M.J., Flier, J.S. Hypertension (1992) [Pubmed]
  23. Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. Virdis, A., Neves, M.F., Amiri, F., Touyz, R.M., Schiffrin, E.L. J. Hypertens. (2004) [Pubmed]
  24. Increased atherosclerotic lesion area in apoE deficient mice overexpressing bovine growth hormone. Andersson, I.J., Ljungberg, A., Svensson, L., Gan, L.M., Oscarsson, J., Bergström, G. Atherosclerosis (2006) [Pubmed]
  25. Modulation of insulin resistance and hypertension by voluntary exercise training in the TG(mREN2)27 rat. Kinnick, T.R., Youngblood, E.B., O'Keefe, M.P., Saengsirisuwan, V., Teachey, M.K., Henriksen, E.J. J. Appl. Physiol. (2002) [Pubmed]
  26. Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. Tilley, S.L., Audoly, L.P., Hicks, E.H., Kim, H.S., Flannery, P.J., Coffman, T.M., Koller, B.H. J. Clin. Invest. (1999) [Pubmed]
  27. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Barton, M., Haudenschild, C.C., d'Uscio, L.V., Shaw, S., Münter, K., Lüscher, T.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. Sinal, C.J., Miyata, M., Tohkin, M., Nagata, K., Bend, J.R., Gonzalez, F.J. J. Biol. Chem. (2000) [Pubmed]
  29. Angiotensin converting-enzyme inhibitor treatment reduces glomerular p16INK4 and p27Kip1 expression in diabetic BBdp rats. Wolf, G., Wenzel, U., Ziyadeh, F.N., Stahl, R.A. Diabetologia (1999) [Pubmed]
  30. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Daugherty, A., Rateri, D.L., Lu, H., Inagami, T., Cassis, L.A. Circulation (2004) [Pubmed]
  31. Inhibition of aortic aneurysm development in blotchy mice by beta adrenergic blockade independent of altered lysyl oxidase activity. Moursi, M.M., Beebe, H.G., Messina, L.M., Welling, T.H., Stanley, J.C. J. Vasc. Surg. (1995) [Pubmed]
  32. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Wassmann, S., Czech, T., van Eickels, M., Fleming, I., Böhm, M., Nickenig, G. Circulation (2004) [Pubmed]
  33. Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. Oliverio, M.I., Best, C.F., Smithies, O., Coffman, T.M. Hypertension (2000) [Pubmed]
  34. Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression. Takemura, Y., Fukuo, K., Yasuda, O., Inoue, T., Inomata, N., Yokoi, T., Kawamoto, H., Suhara, T., Ogihara, T. Hypertension (2004) [Pubmed]
  35. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Ito, M., Oliverio, M.I., Mannon, P.J., Best, C.F., Maeda, N., Smithies, O., Coffman, T.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  36. Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene. Emanueli, C., Fink, E., Milia, A.F., Salis, M.B., Conti, M., Demontis, M.P., Madeddu, P. Hypertension (1998) [Pubmed]
  37. The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice. Williams, J., Bogwu, J., Oyekan, A. J. Hypertens. (2006) [Pubmed]
  38. Model of robust induction of glomerulosclerosis in mice: importance of genetic background. Ma, L.J., Fogo, A.B. Kidney Int. (2003) [Pubmed]
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