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Chemical Compound Review:

Femedol 5-methoxy-1H-indole

Synonyms: PubChem7432, SureCN74720, AGN-PC-00SV3G, CHEMBL280311, ACMC-1BMAQ, ...

Balemans, M.G. et al., Cardinali, D.P. et al., Balemans, M.G. et al., Kemerer, V.F. et al.

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High impact information on Femedol

In vitro effects of estradiol, testosterone, and progesterone on 5-methoxyindole content, cyclic adenosine 3',5'-monophosphate synthesis, and norepinephrine release in different parts of the female guinea pig pineal complex [1].
In the pineal of the mouse "eyeless", a low 5-methoxyindole synthesis showing no circadian rhythm is demonstrated [2].
5-Methoxyindole synthesis is extremely high in the Harderian gland, whereas in the retina HIOMT activity is low and variable [2].
Correction for interfering 5-methoxytryptamine and 5-methoxyindole acetic acid is accomplished by a second measurement at alkaline pH [3].
It may be concluded that reduced neopterin and pterin-6-aldehyde influenced the activity and the circadian rhythmicity of 5-methoxyindole synthesis [4].

References

In vitro effects of estradiol, testosterone, and progesterone on 5-methoxyindole content, cyclic adenosine 3',5'-monophosphate synthesis, and norepinephrine release in different parts of the female guinea pig pineal complex. Cardinali, D.P., Vacas, M.I., Solveyra, C.G., Sarmiento, M.I., Vollrath, L. J. Pineal Res. (1986) [Pubmed]
Preliminary investigations of melatonin and 5-methoxy-tryptophol synthesis in the pineal, retina, and harderian gland of the mole rat and in the pineal of the mouse "eyeless". Balemans, M.G., Pévet, P., Legerstee, W.C., Nevo, E. J. Neural Transm. (1980) [Pubmed]
A column chromatographic method for the determination of 5-hydroxytryptamine (serotonin) and 5-hydroxyindole acetic acid in cerebrospinal fluid. Kemerer, V.F., Lichtenfeld, K.M., Koch, T.R. Clin. Chim. Acta (1979) [Pubmed]
The influence of some pterins on the circadian rhythmicity of hydroxyindole-O-methyl transferase in the pineal gland of 42-day old male Wistar rats. Balemans, M.G., Van Benthem, J., Legerstee, W.C., de Moree, A., Noteborn, H.J., Ebels, I. Reproduction, nutrition, development. (1980) [Pubmed]

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