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Chemical Compound Review

SureCN436330     1H-pyrrole-2,3,5-tricarboxylic acid

Synonyms: AG-H-90309, CTK3I7544, CL4522, WT1338, AKOS006321511, ...
 
 
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Disease relevance of Pyrrole-2,3,5-tricarboxylic acid

  • Median level of PTCA in melanoma patients was elevated 2.1-fold compared with control subjects [1].
 

High impact information on Pyrrole-2,3,5-tricarboxylic acid

 

Anatomical context of Pyrrole-2,3,5-tricarboxylic acid

 

Associations of Pyrrole-2,3,5-tricarboxylic acid with other chemical compounds

 

Gene context of Pyrrole-2,3,5-tricarboxylic acid

 

Analytical, diagnostic and therapeutic context of Pyrrole-2,3,5-tricarboxylic acid

  • The degradation products, PTCA and AHP, were determined by high-performance liquid chromatography [8].
  • The PTCA values obtained by means of HPLC were correlated with the near infrared spectrum of the respective samples [9].
  • For epidemiological studies, chromatographic methods of determining pyrrole-2,3,5-tricarboxylic acid (PTCA; the principal marker of eumelanin) are long, laborious and unsuitable for screening large populations [9].
  • A correlation between the PTCA values obtained by means of HPLC and the PTCA values obtained from an analysis of the spectra was obtained using the principal component regression (PCR) algorithm [9].

References

  1. Determination of eumelanin in human urine. Wakamatsu, K., Takasaki, A., Kågedal, B., Kageshita, T., Ito, S. Pigment Cell Res. (2006) [Pubmed]
  2. Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture. Hirobe, T., Wakamatsu, K., Ito, S., Abe, H., Kawa, Y., Mizoguchi, M. J. Cell. Physiol. (2002) [Pubmed]
  3. High-performance liquid chromatography (HPLC) analysis of eu- and pheomelanin in melanogenesis control. Ito, S. J. Invest. Dermatol. (1993) [Pubmed]
  4. Induction of melanization within hair bulb melanocytes in chinchilla mutant by melanogenic stimulants. Imokawa, G., Yada, Y., Hori, Y. J. Invest. Dermatol. (1988) [Pubmed]
  5. Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes. Liu, Y., Hong, L., Wakamatsu, K., Ito, S., Adhyaru, B.B., Cheng, C.Y., Bowers, C.R., Simon, J.D. Photochem. Photobiol. (2005) [Pubmed]
  6. Melanins and lens pigments: a comparative study. Cuevas, A.A., García-Castiñeiras, S. Puerto Rico health sciences journal. (1993) [Pubmed]
  7. Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Hirobe, T., Wakamatsu, K., Ito, S. Eur. J. Cell Biol. (1998) [Pubmed]
  8. Quantitative analysis of eumelanin and pheomelanin in hair and melanomas. Ito, S., Jimbow, K. J. Invest. Dermatol. (1983) [Pubmed]
  9. Near infrared spectroscopy as a tool for the determination of eumelanin in human hair. Zoccola, M., Mossotti, R., Innocenti, R., Loria, D.I., Rosso, S., Zanetti, R. Pigment Cell Res. (2004) [Pubmed]
 
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