Disease relevance of hydrogen iodide

• "Total" acidic metabolites of catecholamines in urine as determined by hydrolysis with hydriodic acid and liquid chromatography: application to patients with neuroblastoma and melanoma [1].
• Pyrole 2,3,6 tricarboxylic acid (PTCA) and amino hydroxy phenylalanine (AHP) were identified by HPLC after permanganate oxidation and hydroiodic acid hydrolysis, respectively, of a choroidal melanoma obtained at enucleation [2].
• Myoglobinuria and hypocalcemia after a superficial hydriodic acid burn [3].

High impact information on hydrogen iodide

• Lack of the specific degradation products aminohydroxyphenylalanine and aminohydroxyphenylethylamine in Lacc+ strains upon hydriodic acid hydrolysis showed that pheomelanin was also not produced by the fungus in vivo [4].
• Substitution of uridine at the GU with base analogues containing a large methyl or iodo group, but not a smaller flouro group at base position 5, interferes with association of 5'SS RNA with snRNP complexes and their functional participation in splicing [5].
• The hydrophobic portion of the lipid was identified as diphytanyl glycerol diether on the basis of the mass spectrum of the acetolysis product and gas-liquid chromatography of the iodinated alkyl chain prepared by hydroiodic acid cleavage of PNL2 [6].
• Previously, we utilized 4-iodopyrazole (4IPzH) as a heavy atom derivative for the initial solution of the crystal structure of the nitrophorin from Rhodnius prolixus, NP1, where it was found to bind to the heme with the iodo group disordered in two positions [7].
• 5. Adding an iodo group to the 5-position of UBP277 and UBP282 enhanced activity at kainate receptors (UBP291 and UBP301 antagonised kainate responses on the dorsal root with apparent K(D) values of 9.83+/-1.62 and 5.94+/-0.63 micro M, respectively) [8].

Biological context of hydrogen iodide

• It was isolated in a yield of 0.5 mg/eye and its physical and chemical characteristics, especially reductive hydrolysis with hydriodic acid giving dopa (3,4-dihydroxyphenylalanine) and cysteine, suggested that it might to SS-dicysteinyldopa [9].
• Hydroiodic acid attachment kinetics as a chemical probe of gaseous protein ion structure: bovine pancreatic trypsin inhibitor [10].
• Hydroxyflavonols were prepared by dealkylation of methoxyflavonols by refluxing in hydroiodic acid [11].

Associations of hydrogen iodide with other chemical compounds

• We describe a method for determining the "total" excretion of acidic metabolites of catecholamines by measuring 3,4-dihydroxyphenylacetic acid (DOPAC) formed by hydriodic acid hydrolysis of 4-hydroxy-3-methoxyphenylacetic acid (HVA), 4-hydroxy-3-methoxymandelic acid (VMA), and their conjugates [1].
• Dopamine- and 3,4-dihydroxyphenylalanine-melanin products were identified after acidic permanganate oxidation, alkaline hydrogen peroxide oxidation, or hydrolysis with hydriodic acid [12].
• On the basis of this hypothesis, synthetic neuromelanins were obtained by tyrosinase oxidation of dopamine in the presence of various ratios of cysteine and were hydrolyzed with hydriodic acid to obtain 4-amino-3-hydroxyphenylethylamine (AHPEA) [13].
• Reductive hydrolysis of pheomelanin with hydriodic acid (HI) gives two aminohydroxyphenylalanine isomers, 4-amino-3-hydroxyphenylalanine ('specific AHP') and 3-amino-4-hydroxyphenylalanine (3-aminotyrosine, AT), which derive from the oxidative polymerization of 5-S-cysteinyldopa, and 2-S-cysteinyldopa, respectively [14].
• The rationale is that permanganate oxidation of eumelanin yields pyrrole-2,3,5-tricarboxylic acid (PTCA) which may serve as a quantitatively significant indicator of eumelanin, while hydriodic acid hydrolysis of pheomelanin yields aminohydroxyphenylalanine (AHP) as a specific indicator of pheomelanin [15].

Gene context of hydrogen iodide

• An antiserum against alpha-amino-(4-hydroxy-6-benzothiazolyl)propionic acid (AHBP), a major product obtained after hydriodic acid hydrolysis of pheomelanin, was raised in rabbits immunized with AHBP coupled to bovine serum albumin (BSA) [16].
• The analytical procedure includes extraction of PAH and PAH metabolites from urine using commercial cartridges containing C18-modified silica, reduction of metabolites to PAH by hydriodic acid and subsequent analysis of the PAH by high performance liquid chromatography with fluorescence detection [17].

Analytical, diagnostic and therapeutic context of hydrogen iodide

• The reaction mixture was first purified by chiral HPLC followed by deprotection using hydriodic acid [18].

References