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Chemical Compound Review

iodane     iodane

Synonyms: iodium, yodo, Hydrogeniodid, Iodwasserstoff, Jodwasserstoff, ...
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Disease relevance of hydrogen iodide


High impact information on hydrogen iodide

  • Lack of the specific degradation products aminohydroxyphenylalanine and aminohydroxyphenylethylamine in Lacc+ strains upon hydriodic acid hydrolysis showed that pheomelanin was also not produced by the fungus in vivo [4].
  • Substitution of uridine at the GU with base analogues containing a large methyl or iodo group, but not a smaller flouro group at base position 5, interferes with association of 5'SS RNA with snRNP complexes and their functional participation in splicing [5].
  • The hydrophobic portion of the lipid was identified as diphytanyl glycerol diether on the basis of the mass spectrum of the acetolysis product and gas-liquid chromatography of the iodinated alkyl chain prepared by hydroiodic acid cleavage of PNL2 [6].
  • Previously, we utilized 4-iodopyrazole (4IPzH) as a heavy atom derivative for the initial solution of the crystal structure of the nitrophorin from Rhodnius prolixus, NP1, where it was found to bind to the heme with the iodo group disordered in two positions [7].
  • 5. Adding an iodo group to the 5-position of UBP277 and UBP282 enhanced activity at kainate receptors (UBP291 and UBP301 antagonised kainate responses on the dorsal root with apparent K(D) values of 9.83+/-1.62 and 5.94+/-0.63 micro M, respectively) [8].

Biological context of hydrogen iodide


Associations of hydrogen iodide with other chemical compounds


Gene context of hydrogen iodide

  • An antiserum against alpha-amino-(4-hydroxy-6-benzothiazolyl)propionic acid (AHBP), a major product obtained after hydriodic acid hydrolysis of pheomelanin, was raised in rabbits immunized with AHBP coupled to bovine serum albumin (BSA) [16].
  • The analytical procedure includes extraction of PAH and PAH metabolites from urine using commercial cartridges containing C18-modified silica, reduction of metabolites to PAH by hydriodic acid and subsequent analysis of the PAH by high performance liquid chromatography with fluorescence detection [17].

Analytical, diagnostic and therapeutic context of hydrogen iodide


  1. "Total" acidic metabolites of catecholamines in urine as determined by hydrolysis with hydriodic acid and liquid chromatography: application to patients with neuroblastoma and melanoma. Ito, S., Kato, T., Maruta, K., Jimbow, K., Fujita, K. Clin. Chem. (1985) [Pubmed]
  2. Electron spin resonance and high pressure liquid chromatographic analysis of melanin in posterior choroidal melanomas. Angiolillo, P.J., Donoso, L.A., Folberg, R., Augsburger, J.J., Wax, M. Cancer Biochem. Biophys. (1985) [Pubmed]
  3. Myoglobinuria and hypocalcemia after a superficial hydriodic acid burn. Lionelli, G.T., Pickus, E.J., Bray, J.G., Lawrence, W.T., Korentager, R.A. The Journal of burn care & rehabilitation. (2001) [Pubmed]
  4. Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice. Liu, L., Wakamatsu, K., Ito, S., Williamson, P.R. Infect. Immun. (1999) [Pubmed]
  5. The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome. Reyes, J.L., Kois, P., Konforti, B.B., Konarska, M.M. RNA (1996) [Pubmed]
  6. A diphytanyl ether analog of phosphatidylserine from a methanogenic bacterium, Methanobrevibacter arboriphilus. Morii, H., Nishihara, M., Ohga, M., Koga, Y. J. Lipid Res. (1986) [Pubmed]
  7. Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4. Berry, R.E., Ding, X.D., Shokhireva, T.K.h., Weichsel, A., Montfort, W.R., Walker, F.A. J. Biol. Inorg. Chem. (2004) [Pubmed]
  8. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. More, J.C., Troop, H.M., Dolman, N.P., Jane, D.E. Br. J. Pharmacol. (2003) [Pubmed]
  9. A new amino acid, 3-(2,5-SS-dicysteinyl-3,4-dihydroxyphenyl)alanine, from the tapetum lucidum of the gar (Lepisosteidae) and its enzymic synthesis. Ito, S., Nicol, J.A. Biochem. J. (1977) [Pubmed]
  10. Hydroiodic acid attachment kinetics as a chemical probe of gaseous protein ion structure: bovine pancreatic trypsin inhibitor. Stephenson, J.L., Schaaff, T.G., McLuckey, S.A. J. Am. Soc. Mass Spectrom. (1999) [Pubmed]
  11. Effect of flavonol derivatives on the carrageenin-induced paw edema in the rat and inhibition of cyclooxygenase-1 and 5-lipoxygenase in vitro. Sobottka, A.M., Werner, W., Blaschke, G., Kiefer, W., Nowe, U., Dannhardt, G., Schapoval, E.E., Schenkel, E.P., Scriba, G.K. Arch. Pharm. (Weinheim) (2000) [Pubmed]
  12. Melanin biosynthesis in Cryptococcus neoformans. Williamson, P.R., Wakamatsu, K., Ito, S. J. Bacteriol. (1998) [Pubmed]
  13. Cysteinyldopamine is not incorporated into neuromelanin. Wakamatsu, K., Ito, S., Nagatsu, T. Neurosci. Lett. (1991) [Pubmed]
  14. The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin. Wakamatsu, K., Ito, S., Rees, J.L. Pigment Cell Res. (2002) [Pubmed]
  15. Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography. Ito, S., Fujita, K. Anal. Biochem. (1985) [Pubmed]
  16. Analysis and quantification of pheomelanins by radioimmunoassay. Ahene, A.B., Chedekel, M.R., Koch, W.H., Maldonado, W. Pigment Cell Res. (1988) [Pubmed]
  17. Determination of exposure to polycyclic aromatic hydrocarbons by analysis of human urine. Becher, G., Bjørseth, A. Cancer Lett. (1983) [Pubmed]
  18. Routine synthesis of carbon-11-carboxyl-labeled L-dopa. Adam, M.J., Grierson, J.R., Ruth, T.J., Pedersen, K., Pate, B.D. J. Nucl. Med. (1987) [Pubmed]
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