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Chemical Compound Review:

SureCN260994 3-methyl-1,3-dihydroindol-2- one

Synonyms: SureCN7642293, CHEBI:17397, AC1Q2QFN, KB-68781, CTK4C6630, ...

Skordos, K.W. et al., Hanafy, M.S. et al., Gu, J.D. et al.

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High impact information on C02366

The 18O incorporation into 3-methyloxindole from 18O2 was 91%, strongly implicating a mechanism requiring cytochrome P450-mediated oxygenation [1].
Through incubations of goat lung microsomes with [2-2H]-3-methylindole, the retention of 2H in 3-methyloxindole was found to be 81%, indicating a majority of the oxindole was produced by the mechanism described above [1].
Degradation proceeded through an initial hydroxylation reaction forming 3-methyloxindole [2].
Strips of smooth muscle from the pulmonary vein, pulmonary artery, trachea and bronchus of calves were incubated in an organ bath with 3-methylindole (3MI) and 3-methyloxindole (3MOI) [3].

References

Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole. Skordos, K.W., Skiles, G.L., Laycock, J.D., Lanza, D.L., Yost, G.S. Chem. Res. Toxicol. (1998) [Pubmed]
Metabolism of 3-methylindole by a methanogenic consortium. Gu, J.D., Berry, D.F. Appl. Environ. Microbiol. (1992) [Pubmed]
Failure of 3-methylindole to contract the bovine pulmonary vein or to release mediators of anaphylaxis from the bovine lung in vitro. Hanafy, M.S., Bogan, J.A. Vet. Res. Commun. (1982) [Pubmed]

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