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MeSH Review

Pulmonary Veins

 
 
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Disease relevance of Pulmonary Veins

 

High impact information on Pulmonary Veins

 

Chemical compound and disease context of Pulmonary Veins

 

Biological context of Pulmonary Veins

 

Anatomical context of Pulmonary Veins

  • The common pulmonary vein, which connected the pulmonary veins to a systemic vein in the abdomen, was seen lying parallel and anterior to the descending aorta and to the left of the inferior vena cava [21].
  • Fatemapping studies using a Pitx2 cre recombinase knock-in allele showed that daughters of Pitx2-expressing cells populated the right and left ventricles, atrioventricular cushions and valves and pulmonary veins [16].
  • Tumor emboli trapped in the vessels of lungs and lymph nodes and single tumor cells observed in the pulmonary vein implied that FGF-1-overexpressing MCF-7 cells are deficient in their ability to extravasate [22].
  • We conclude that remodeling of the pulmonary vasculature in PPH routinely includes thickening of the arterial adventitia and frequently also includes changes in the walls of the pulmonary veins [23].
  • The CI (267 +/- 54 ms vs. 217 +/- 55 ms, p < 0.05), AF1 (194 +/- 36 ms vs. 153 +/- 37 ms, p < 0.05) and PI (0.49 +/- 0.13 vs. 0.37 +/- 0.11, p < 0.01) of the AF episodes from the superior vena cava (SVC) were significantly longer and greater than those of AF episodes from pulmonary veins (PVs) [24].
 

Associations of Pulmonary Veins with chemical compounds

 

Gene context of Pulmonary Veins

  • At the venous pole, BMP2, -5, and -7 mRNA are expressed in the distal myocardial border of the caval vein, while BMP2, -5, -6, and -7 mRNA are expressed in the distal myocardium around the pulmonary vein [28].
  • In the pulmonary vein plasma levels of activated factor VII decreased following heparin administration (P < 0.001) in the majority of patients which was coincidental to an increase (P < 0.001) in tissue factor pathway inhibitor (TFPI) [29].
  • Lungs of eNOS-deficient mice also exhibited a striking paucity of distal arteriolar branches and extensive regions of capillary hypoperfusion, together with misalignment of pulmonary veins, which represent the characteristic features of alveolar capillary dysplasia [30].
  • However, in isolated human pulmonary veins two receptors are present, CysLT1 and CysLT2 (Figure 1) [31].
  • At 2 months post-injection, lacZ expression persisted only in atrial tissues, pulmonary veins, and great vessels [32].
 

Analytical, diagnostic and therapeutic context of Pulmonary Veins

References

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  20. 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptors. Cocks, T.M., Arnold, P.J. Br. J. Pharmacol. (1992) [Pubmed]
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  22. Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes. Zhang, L., Kharbanda, S., McLeskey, S.W., Kern, F.G. Cancer Res. (1999) [Pubmed]
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  28. Dynamic patterns of expression of BMP isoforms 2, 4, 5, 6, and 7 during chicken heart development. Somi, S., Buffing, A.A., Moorman, A.F., Van Den Hoff, M.J. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2004) [Pubmed]
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