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Chemical Compound Review:

AG-D-63414 1,4-diaminobutan-2-one

Synonyms: CTK4B7170, AKOS006220478, AC1L46XI, 13123-70-1, EINECS 222-914-0, ...

Reyna-López, G.E. et al., Martinez, J.P. et al., Garcia, A.F. et al., Pec, P. et al., Cano-Canchola, C. et al., et al.

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High impact information on NSC60541

Treatment of T. vaginalis T016 with >/=20 mM 1,4-diamino-2-butanone (DAB) to inhibit ODC resulted in growth arrest, which was reversed by addition of exogenous putrescine [1].
The effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from Aspergillus nidulans [2].
Development, demethylation, and transcription of CUP genes were blocked by the ornithine decarboxylase inhibitor 1,4-diaminobutanone [3].
In the case of pea DAO all inhibitors compete for the same subsites with 1,4-diamino-2-butanone and 1,5-diamino-3-pentanone (alpha = infinity) [4].

Biological context of NSC60541

To determine the specificity of differential methylation in regards to dimorphism, we obtained the yeast-like form of the three fungi under conditions that induced mycelial growth, by addition of 1,4-diaminobutanone (DAB), an inhibitor of ornithine decarboxylase in the case of M. rouxii and Y. lipolytica [5].

Anatomical context of NSC60541

Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprotein composition of the cell wall [6].

References

Trichomonas vaginalis polyamine metabolism is linked to host cell adherence and cytotoxicity. Garcia, A.F., Benchimol, M., Alderete, J.F. Infect. Immun. (2005) [Pubmed]
The effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from Aspergillus nidulans. Stevens, L., McKinnon, I.M. Biochem. J. (1977) [Pubmed]
Developmental regulation of CUP gene expression through DNA methylation in Mucor spp. Cano-Canchola, C., Sosa, L., Fonzi, W., Sypherd, P., Ruiz-Herrera, J. J. Bacteriol. (1992) [Pubmed]
Comparison of coupling subsites and inhibition effects of piperidine alkaloids and aminoketones on plant amine oxidases. Pec, P., Frébort, I. J. Enzym. Inhib. (1991) [Pubmed]
Specificity of DNA methylation changes during fungal dimorphism and its relationship to polyamines. Reyna-López, G.E., Ruiz-Herrera, J. Curr. Microbiol. (2004) [Pubmed]
Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprotein composition of the cell wall. Martinez, J.P., Lopez-Ribot, J.L., Gil, M.L., Sentandreu, R., Ruiz-Herrera, J. J. Gen. Microbiol. (1990) [Pubmed]

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