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Chemical Compound Review:

Pendepon N,N'-dibenzylethane-1,2- diamine; (2R,5R...

Synonyms: Benzapen, Cillenta, Penduran, Penidural, Cepacilina, ...

McClean, H. et al., Daniels, E.D. et al., Vignes, S. et al., Prabhakaran, K. et al., Kassem, A.S. et al., et al.

Vignes, Dupuy, McClean, Daniels, Carne, Bunting, Miller,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tardocillin

Rheumatic fever prophylaxis using benzathine penicillin G (BPG): two- week versus four-week regimens: comparison of two brands of BPG [1].
Only 19 (14%) clinics indicated not routinely using the recommended procaine penicillin G (PPG) regimen or one- or two-dose benzathine penicillin G (BPG) regimens for early syphilis, with 57% providing two doses of BPG 2.4 g, 40% providing PPG 750 mg for 10 days, and 15% providing one dose of BPG 2.4 g [2].
Compartment syndrome in the leg requiring fasciotomy after bicillin injection in the thigh [3].
OBJECTIVE: To identify the predictors of successful antibiotic prophylactic treatment using benzathin-penicillin G to prevent recurrence of erysipelas in patients with secondary upper limb lymphoedema [4].

High impact information on Tardocillin

However, the bacteria obtained from the tissues of armadillos treated with penicillin G benzathine (bicillin) 6 months or more prior to sacrifice had beta-lactamase [5].

Chemical compound and disease context of Tardocillin

Rheumatic fever is a major health problem in South Africa. Although intramuscular benzathine penicillin (bicillin) 1.2 million units (MU) every 4 weeks is widely used for secondary prophylaxis, studies in other countries have shown a recurrence rate of 3-8% over 5-6 years in patients on this regimen [6].

References

Rheumatic fever prophylaxis using benzathine penicillin G (BPG): two- week versus four-week regimens: comparison of two brands of BPG. Kassem, A.S., Zaher, S.R., Abou Shleib, H., el-Kholy, A.G., Madkour, A.A., Kaplan, E.L. Pediatrics (1996) [Pubmed]
UK National Audit of Early Syphilis Management. Clinics audit: screening for and management of early syphilis. McClean, H., Daniels, D., Carne, C., Bunting, P., Miller, R. International journal of STD & AIDS. (2006) [Pubmed]
Compartment syndrome in the leg requiring fasciotomy after bicillin injection in the thigh. Westrich, G.H., Toledano, B. Orthopedics. (1995) [Pubmed]
Recurrence of lymphoedema-associated cellulitis (erysipelas) under prophylactic antibiotherapy: a retrospective cohort study. Vignes, S., Dupuy, A. Journal of the European Academy of Dermatology and Venereology : JEADV. (2006) [Pubmed]
Beta-lactamase synthesis in Mycobacterium leprae. Prabhakaran, K., Harris, E.B., Sanchez, R.M., Hastings, R.C. Microbios (1987) [Pubmed]
Rheumatic fever prophylaxis in South Africa--is bicillin 1,2 million units every 4 weeks appropriate? Daniels, E.D., Mohanlal, D., Pettifor, J.M. S. Afr. Med. J. (1994) [Pubmed]

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