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Chemical Compound Review

Duphapen     2-diethylaminoethyl 4-aminobenzoate; (2R...

Synonyms: Nopcaine, Vetspen, Vitablend, Depocillin, Hostacillin, ...
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Disease relevance of Procaine penicillin G

  • One hundred and seven men with culture-proved gonococcal urethritis were given a single dose of either procaine penicillin G, 4.8 million U, or cefoxitin, 2 g, intramuscularly [1].
  • Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously [2].
  • Uncomplicated gonorrhea of 122 mucosal sites in 51 women was successfully treated with either a single intramuscular dose of 250 mg of ceftriaxone (23 patients) or two intramuscular doses of 4.8 X 10(6) U of aqueous procaine penicillin G (28 patients) [3].
  • Ninety-seven patients with 118 sites infected with Neisseria gonorrhoeae were treated with a single dose of either procaine penicillin G (4.8 x 10(6) U) or cefotoxime (1.0 g) intramuscularly [4].
  • The condylomata lata responded well to treatment of the syphilis with procaine penicillin G [5].

Psychiatry related information on Procaine penicillin G


High impact information on Procaine penicillin G


Chemical compound and disease context of Procaine penicillin G


Biological context of Procaine penicillin G


Anatomical context of Procaine penicillin G


Associations of Procaine penicillin G with other chemical compounds


Gene context of Procaine penicillin G


Analytical, diagnostic and therapeutic context of Procaine penicillin G


  1. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. Berg, S.W., Kilpatrick, M.E., Harrison, W.O., McCutchan, J.A. N. Engl. J. Med. (1979) [Pubmed]
  2. LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci. Bayer, A.S., Yih, J., Hirano, L. Antimicrob. Agents Chemother. (1988) [Pubmed]
  3. Comparative study of ceftriaxone and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in women. Judson, F.N., Ehret, J.M., Root, C.J. Antimicrob. Agents Chemother. (1983) [Pubmed]
  4. Treatment of gonorrhea: comparison of cefotaxime and penicillin. Simpson, M.L., Khan, M.Y., Siddiqui, Y., Gruninger, R.P., Wigren, D.I. Antimicrob. Agents Chemother. (1981) [Pubmed]
  5. Solitary oral condylomata lata in a patient with secondary syphilis. de Swaan, B., Tjiam, K.H., Vuzevski, V.D., Van Joost, T., Stolz, E. Sexually transmitted diseases. (1985) [Pubmed]
  6. Panic attack following injection of aqueous procaine penicillin G (Hoigné syndrome). Silber, T.J., D'Angelo, L.J. J. Pediatr. (1985) [Pubmed]
  7. Penicillin treatment accelerates middle ear inflammation in experimental pneumococcal otitis media. Kawana, M., Kawana, C., Giebink, G.S. Infect. Immun. (1992) [Pubmed]
  8. Significance of in-vitro penicillin tolerance in experimental enterococcal endocarditis. Kim, K.S., Bayer, A.S. J. Antimicrob. Chemother. (1987) [Pubmed]
  9. Cerebrospinal fluid concentrations of aqueous procaine penicillin G in the neonate. Speer, M.E., Mason, E.O., Scharnberg, J.T. Pediatrics (1981) [Pubmed]
  10. Comparison of cefuroxime and penicillin in the treatment of uncomplicated gonorrhea. Lossick, J.G., Thompson, S.E., Smeltzer, M.P. Antimicrob. Agents Chemother. (1982) [Pubmed]
  11. Comparison of piperacillin and penicillin in the treatment of uncomplicated gonorrhea. Simpson, M.L., Khan, M.Y., Siddiqui, Y., Gruninger, R.P., Wigren, D.I. Antimicrob. Agents Chemother. (1982) [Pubmed]
  12. Acute pelvic inflammatory disease: characteristics of patients with gonococcal and nongonococcal infection and evaluation of their response to treatment with aqueous procaine penicillin G and spectinomycin hydrochloride. McCormack, W.M., Nowroozi, K., Alpert, S., Sackel, S.G., Lee, Y.H., Lowe, E.W., Rankin, J.S. Sexually transmitted diseases. (1977) [Pubmed]
  13. Single-dose treatment of uncomplicated acute gonococcal urethritis in Ethiopian men: comparison of rosoxacin, spectinomycin, penicillin, and ampicillin. Habte-Gabr, E., Geyid, A., Serdo, D., Biddle, J., Perine, P.L. Sexually transmitted diseases. (1987) [Pubmed]
  14. Efficacy of antimicrobial treatments and vaccination regimens for control of porcine reproductive and respiratory syndrome virus and Streptococcus suis coinfection of nursery pigs. Halbur, P., Thanawongnuwech, R., Brown, G., Kinyon, J., Roth, J., Thacker, E., Thacker, B. J. Clin. Microbiol. (2000) [Pubmed]
  15. Effect of the injection site on the pharmacokinetics of procaine penicillin G in horses. Firth, E.C., Nouws, J.F., Driessens, F., Schmaetz, P., Peperkamp, K., Klein, W.R. Am. J. Vet. Res. (1986) [Pubmed]
  16. Ozonation of Procaine Penicillin G formulation effluent Part I: Process optimization and kinetics. Arslan-Alaton, I., Caglayan, A.E. Chemosphere (2005) [Pubmed]
  17. Bioavailability and disposition of sodium and procaine penicillin G (benzylpenicillin) administered orally with milk to calves. Musser, J.M., Anderson, K.L. J. Vet. Pharmacol. Ther. (2001) [Pubmed]
  18. Dairy herd health management. Snider, E.L. Modern veterinary practice. (1984) [Pubmed]
  19. Effect of vitamin A (Vitablend W. M. Forte) feed supplementation on semen production of Jaffrabadi buffalo bulls. Kerur, V.K., Shersia, A.H., Bhavsar, B.K. The Indian veterinary journal. (1979) [Pubmed]
  20. Concentrations of sulphadimidine, oxytetracycline and penicillin G in serum, synovial fluid and tissue cage fluid after parenteral administration to calves. Bengtsson, B., Franklin, A., Luthman, J., Jacobsson, S.O. J. Vet. Pharmacol. Ther. (1989) [Pubmed]
  21. Distribution of penicillin-G and spiramycin to tissue cages and subcutaneous tissue fluid in calves. Bengtsson, B., Franklin, A., Jacobsson, S., Luthman, J., Horn af Rantzien, M. Res. Vet. Sci. (1991) [Pubmed]
  22. Treatment of women with uncomplicated gonococcal infection. Fiumara, N.J. Sexually transmitted diseases. (1980) [Pubmed]
  23. Inflammatory response to intramuscular implantation of polyacrylonitrile ultrafiltration probes in sheep. Imsilp, K., Whittem, T., Koritz, G.D., Zachary, J.F., Schaeffer, D.J. Vet. Res. (2000) [Pubmed]
  24. Infected total hip arthroplasty due to Actinomyces israelii after dental extraction. A case report. Strazzeri, J.C., Anzel, S. Clin. Orthop. Relat. Res. (1986) [Pubmed]
  25. Biological treatability of raw and ozonated synthetic penicillin formulation effluent. Cokgor, E.U., Karahan, O., Arslan-Alaton, I., Saruhan, H., Orhon, D. Water Sci. Technol. (2005) [Pubmed]
  26. Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G. Craigmill, A.L., Miller, G.R., Gehring, R., Pierce, A.N., Riviere, J.E. J. Vet. Pharmacol. Ther. (2004) [Pubmed]
  27. Efficacy of targeted 5-day combined parenteral and intramammary treatment of clinical mastitis caused by penicillin-susceptible or penicillin-resistant Staphylococcus aureus. Taponen, S., Jantunen, A., Pyörälä, E., Pyörälä, S. Acta Vet. Scand. (2003) [Pubmed]
  28. Systemic toxic reactions to procaine penicillin G. Downham, T.F., Cawley, R.A., Salley, S.O., Dal Santo, G. Sexually transmitted diseases. (1978) [Pubmed]
  29. Effect of 60Co-irradiation on penicillin G procaine in veterinary mastitis products. Tsuji, K., Goetz, J.F., Vanmeter, W. Journal of pharmaceutical sciences. (1979) [Pubmed]
  30. Treatment of Streptococcus agalactiae mastitis in dairy cows: comparative efficacies of two antibiotic preparations and factors associated with successful treatment. Weaver, L.D., Galland, J., Martin, P.A., Versteeg, J. J. Am. Vet. Med. Assoc. (1986) [Pubmed]
  31. Acute nonfatal erysipelas in sows in a commercial farrow-to-finish operation. Amass, S.F., Scholz, D.A. J. Am. Vet. Med. Assoc. (1998) [Pubmed]
  32. A study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection. Papich, M.G., Korsrud, G.O., Boison, J.O., Yates, W.D., MacNeil, J.D., Janzen, E.D., Cohen, R.D., Landry, D.A. J. Vet. Pharmacol. Ther. (1993) [Pubmed]
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