Disease relevance of Procaine penicillin G

• One hundred and seven men with culture-proved gonococcal urethritis were given a single dose of either procaine penicillin G, 4.8 million U, or cefoxitin, 2 g, intramuscularly [1].
• Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously [2].
• Uncomplicated gonorrhea of 122 mucosal sites in 51 women was successfully treated with either a single intramuscular dose of 250 mg of ceftriaxone (23 patients) or two intramuscular doses of 4.8 X 10(6) U of aqueous procaine penicillin G (28 patients) [3].
• Ninety-seven patients with 118 sites infected with Neisseria gonorrhoeae were treated with a single dose of either procaine penicillin G (4.8 x 10(6) U) or cefotoxime (1.0 g) intramuscularly [4].
• The condylomata lata responded well to treatment of the syphilis with procaine penicillin G [5].

Psychiatry related information on Procaine penicillin G

• Panic attack following injection of aqueous procaine penicillin G (Hoigné syndrome) [6].

High impact information on Procaine penicillin G

• Procaine penicillin G given intramuscularly 12 and 36 h after inoculation of pneumococci into the middle ear caused a significant acceleration in the MEF inflammatory cell concentration compared with that in untreated controls, with a significant peak in the inflammatory cell concentration 24 h after pneumococcal inoculation [7].
• Comparative study of ceftriaxone and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in women [3].
• In-vivo studies of aortic valve endocarditis in rabbits treated with procaine penicillin G (300 mg/kg/day) revealed strikingly different responses between infections due to one tolerant and one non-tolerant strain [8].
• These results demonstrate that spirocheticidal levels (greater than or equal to 0.03 microgram/ml) are achieved for at least 24 hours in the CSF following the intramuscular administration of aqueous procaine penicillin G in neonates [9].
• Cerebrospinal fluid concentrations of aqueous procaine penicillin G in the neonate [9].

Chemical compound and disease context of Procaine penicillin G

• In a randomized double-blind trial, 216 men and 142 women infected with uncomplicated gonorrhea were treated with either 1.5 g of cefuroxime or 4.8 x 10(6) U of aqueous procaine penicillin G intramuscularly and 1.0 g of probenecid [10].
• Clinically, piperacillin was as effective as procaine penicillin G in the treatment of gonococcal urethritis in men [11].
• Acute pelvic inflammatory disease: characteristics of patients with gonococcal and nongonococcal infection and evaluation of their response to treatment with aqueous procaine penicillin G and spectinomycin hydrochloride [12].
• A total of 140 Ethiopian men with gonococcal urethritis were randomly assigned to treatment with aqueous procaine penicillin G (4.8 X 10(6) units intramuscularly [im] plus 1.0 g of oral probenicid); oral ampicillin (3.5 g plus 1.0 g of oral probenicid); spectinomycin (2.0 g im); or oral rosoxacin (Acrosoxacin; 300 mg) [13].
• Antimicrobial treatments included daily intramuscular injection with 66,000 IU of procaine penicillin G per kg of body weight on days 8 to 10 (group 3), drinking water medication with 23.1 mg of tiamulin per kg during days 8 to 10 (group 4), and daily intramuscular injection of 5.0 mg of ceftiofur hydrochloride per kg on days 8 to 10 (group 5) [14].

Biological context of Procaine penicillin G

• Effect of the injection site on the pharmacokinetics of procaine penicillin G in horses [15].
• Ozonation of Procaine Penicillin G formulation effluent Part I: Process optimization and kinetics [16].
• Bioavailability and disposition of sodium and procaine penicillin G (benzylpenicillin) administered orally with milk to calves [17].
• Procaine penicillin G solution is infused if the uterus is abnormal at 60 days postpartum [18].

Anatomical context of Procaine penicillin G

• Effect of vitamin A (Vitablend W. M. Forte) feed supplementation on semen production of Jaffrabadi buffalo bulls [19].
• Drug concentrations in serum, synovial fluid and tissue cage fluid (TCF) in calves were measured after single i.m. doses of oxytetracycline hydrochloride (OTC), procaine penicillin G (PPG) and potassium penicillin G (KPG) and single i.v. doses of sulphadimidine (SDM) and OTC [20].
• Antibacterial drug concentrations in serum, tissue cage fluid (TCF) and subcutaneous tissue fluid (SF), sampled either by filter paper discs or by microcapillaries, were measured after single intramuscular injections of potassium penicillin-G (KPG), procaine penicillin-G (PPG) and spiramycin adipate in calves [21].

Associations of Procaine penicillin G with other chemical compounds

• Ninety-three women returned for examination after treatment; 71 were treated with 4.8 X 10(6) units of aqueous procaine penicillin G without probenecid [22].
• Each of 20 normal sheep was implanted with two ultrafiltration probes, one at the site of an injection of procaine or benzathine plus procaine penicillin G [23].
• Recommendations for antibiotic prophylaxis for dental manipulation are a loading dose of 2.0 g of penicillin V orally or 1.2 million U of aqueous procaine penicillin G with 1.0 gram of streptomycin given intramuscularly 30 minutes before dental work, followed by four doses of 0.5 g of penicillin V orally every six hours [24].
• Chemical pre-treatment of synthetic Procaine Penicillin G (PPG) effluent with ozone (applied dose = 1440 mg/h; treatment duration = 60 min) at pH = 7 was investigated [25].
• Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G [26].

Gene context of Procaine penicillin G

• Procaine penicillin G (86 cases due to beta-lactamase negative strains) or amoxycillin-clavulanic acid (24 cases due to beta-lactamase positive strains) was administered parenterally and intramammarily for 5 days [27].

Analytical, diagnostic and therapeutic context of Procaine penicillin G

• Systemic toxic were encountered in eight of 10,469 patients during or immediately following the intramuscular injection of 4,800,000 units of procaine penicillin G for the treatment of gonorrhea [28].
• The HPLC method is capable of separating and quantifying procaine, penicillin G, and various degradation compounds [29].
• Most treatment failures were in one herd in cows that were given procaine penicillin G in sterile saline solution [30].
• Further morbidity and mortality were prevented by treatment of clinically affected sows and all pigs in close proximity with procaine penicillin G daily for 3 consecutive days and vaccination of all pigs with questionable vaccination status, using bacterin of killed Erysipelothrix rhusiopathiae [31].
• A study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection [32].

References