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MeSH Review

Rheumatic Fever

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Disease relevance of Rheumatic Fever


Psychiatry related information on Rheumatic Fever


High impact information on Rheumatic Fever


Chemical compound and disease context of Rheumatic Fever

  • In areas where rheumatic fever is still prevalent, particularly in poor and crowded inner-city populations where medical care is episodic, follow-up may be lacking, and compliance in taking oral penicillin cannot be relied on, treatment with intramuscular penicillin G benzathine remains preferred [11].
  • Anti-streptococcal antibodies cross-reactive with N-acetyl-betaD-glucosamine (GlcNAc) and myosin are present in the sera of patients with rheumatic fever (RF) [13].
  • A 12-15-h incubation of lymphocytes at 37 degrees C in 5% CO2-air showed persistence of CRP binding in substantial proportions of cells particularly in acute rheumatic fever [14].
  • The story of the prevention of rheumatic fever has a large cast of characters, but special recognition must be given to Coburn for his observations confirming the role of the hemolytic streptococcus published in 1931 and showing the prophylactic value of sulfanilamide published in 1939 [15].
  • However, the effect of fluoride on group A streptococci that causes rheumatic fever and acute poststreptococcal glomerulonephritis is not known [16].

Biological context of Rheumatic Fever

  • These data provide evidence that fluoride causes decreased expression by S. pyogenes proteins used to respond to stress, virulence factors, and implicated in non-suppurative complications of S. pyogenes, including glomerulonephritis and rheumatic fever [16].
  • Molecular mimicry or epitope similarity between group A streptococcal M proteins and myosin may contribute to the presence of heart reactive antibodies in acute rheumatic fever [5].
  • In conclusion, it was found that exposure to pharyngeal infection with group A beta haemolytic streptococci may lead to acute rheumatic fever in those with an inherited recessive gene responsible for high responsiveness to the streptococcal polysaccharide antigen of the cell wall [17].
  • This observation increases the significance of the previously observed sequence homology between streptococcal M protein and rabbit skeletal tropomyosin and may have relevance to the pathogenesis of rheumatic fever [18].
  • The aim of the present study was to evaluate the DNA damage in children receiving one dose of 1.2 million units benzathine penicillin every 4 weeks over a long period to prevent recurrences of rheumatic fever [19].

Anatomical context of Rheumatic Fever


Gene context of Rheumatic Fever


Analytical, diagnostic and therapeutic context of Rheumatic Fever


  1. Prophylaxis of streptococcal infections and rheumatic fever: a comparison of orally administered clindamycin and penicillin. Massell, B.F. JAMA (1979) [Pubmed]
  2. Identification of an extracellular plasmin binding protein from nephritogenic streptococci. Poon-King, R., Bannan, J., Viteri, A., Cu, G., Zabriskie, J.B. J. Exp. Med. (1993) [Pubmed]
  3. An analysis of the cost-effectiveness of pharyngitis management and acute rheumatic fever prevention. Tompkins, R.K., Burnes, D.C., Cable, W.E. Ann. Intern. Med. (1977) [Pubmed]
  4. Prevention of Bacterial Endocarditis. A statement for health professionals by the Committee on Rheumatic Fever and Infective Endocarditis of the Council on Cardiovascular Disease in the Young. Shulman, S.T., Amren, D.P., Bisno, A.L., Dajani, A.S., Durack, D.T., Gerber, M.A., Kaplan, E.L., Millard, H.D., Sanders, W.E., Schwartz, R.H. Circulation (1984) [Pubmed]
  5. Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein. Cunningham, M.W., McCormack, J.M., Fenderson, P.G., Ho, M.K., Beachey, E.H., Dale, J.B. J. Immunol. (1989) [Pubmed]
  6. Patient compliance with prophylactic benzathine penicillin for rheumatic fever. Rolston, D.D., Brahmadathan, K.N., Koshi, G., Cherian, G. Med. J. Aust. (1981) [Pubmed]
  7. D8/17 and CD19 expression on lymphocytes of patients with acute rheumatic fever and Tourette's disorder. Weisz, J.L., McMahon, W.M., Moore, J.C., Augustine, N.H., Bohnsack, J.F., Bale, J.F., Johnson, M.B., Morgan, J.F., Jensen, J., Tani, L.Y., Veasy, L.G., Hill, H.R. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
  8. Obsessive compulsive behavior, hyperactivity, and attention deficit disorder in Sydenham chorea. Maia, D.P., Teixeira, A.L., Quintão Cunningham, M.C., Cardoso, F. Neurology (2005) [Pubmed]
  9. Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid. Levy, G., Lampman, T., Kamath, B.L., Garrettson, L.K. N. Engl. J. Med. (1975) [Pubmed]
  10. Ibuprofen and aspirin in acute rheumatic fever. Marshall, R.L. JAMA (1990) [Pubmed]
  11. Treatment of streptococcal pharyngitis revisited. Bass, J.W. JAMA (1986) [Pubmed]
  12. Rheumatic fever-associated Streptococcus pyogenes isolates aggregate collagen. Dinkla, K., Rohde, M., Jansen, W.T., Kaplan, E.L., Chhatwal, G.S., Talay, S.R. J. Clin. Invest. (2003) [Pubmed]
  13. Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin. Galvin, J.E., Hemric, M.E., Ward, K., Cunningham, M.W. J. Clin. Invest. (2000) [Pubmed]
  14. Lymphocytes binding C-reactive protein during acute rheumatic fever. Williams, R.C., Kilpatrick, K.A., Kassaby, M., Abdin, Z.H. J. Clin. Invest. (1978) [Pubmed]
  15. Background of the prevention of cardiovascular disease. II. Arteriosclerosis, hypertension, and selected risk factors. Paul, O. Circulation (1989) [Pubmed]
  16. Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors. Thongboonkerd, V., Luengpailin, J., Cao, J., Pierce, W.M., Cai, J., Klein, J.B., Doyle, R.J. J. Biol. Chem. (2002) [Pubmed]
  17. Immunogenetic study of the response to streptococcal carbohydrate antigen of the cell wall in rheumatic fever. Hafez, M., Abdalla, A., el-Shennawy, F., al-Tonbary, Y., Sheaishaa, A., el-Morsi, Z., Tawfik, S., Settien, A., Abou el-Khair, M. Ann. Rheum. Dis. (1990) [Pubmed]
  18. Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein. Mische, S.M., Manjula, B.N., Fischetti, V.A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  19. Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever. Dündaröz, R., Ulucan, H., Denli, M., Karapinar, K., Aydin, H.I., Baltaci, V. Pediatrics international : official journal of the Japan Pediatric Society. (2001) [Pubmed]
  20. Low density neutrophils in patients with systemic lupus erythematosus, rheumatoid arthritis, and acute rheumatic fever. Hacbarth, E., Kajdacsy-Balla, A. Arthritis Rheum. (1986) [Pubmed]
  21. Aetiology of surgically treated mitral regurgitation. Luxereau, P., Dorent, R., De Gevigney, G., Bruneval, P., Chomette, G., Delahaye, G. Eur. Heart J. (1991) [Pubmed]
  22. Detection of antibodies to muramyl dipeptide, the adjuvant moiety of streptococcal cell wall, in patients with rheumatic fever. Bahr, G.M., Majeed, H.A., Yousof, A.M., Chedid, L., Behbehani, K. J. Infect. Dis. (1986) [Pubmed]
  23. Penicillin failure and copathogenicity in streptococcal pharyngotonsillitis. Brook, I. The Journal of family practice. (1994) [Pubmed]
  24. DRB1, DQA1, DQB1 genes in Turkish children with rheumatic fever. Hallioglu, O., Mesci, L., Ozer, S. Clinical and experimental rheumatology. (2005) [Pubmed]
  25. Plasma interleukin-7 (IL-7) and IL-8 concentrations in acute rheumatic fever and chronic rheumatic heart disease. Kütükçüler, N., Narin, N. Scand. J. Rheumatol. (1995) [Pubmed]
  26. Cytokines in acute rheumatic fever. Yeğin, O., Coşkun, M., Ertuğ, H. Eur. J. Pediatr. (1997) [Pubmed]
  27. Poststreptococcal reactive arthritis: clinical characteristics and association with HLA-DR alleles. Ahmed, S., Ayoub, E.M., Scornik, J.C., Wang, C.Y., She, J.X. Arthritis Rheum. (1998) [Pubmed]
  28. Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels. Kamblock, J., Payot, L., Iung, B., Costes, P., Gillet, T., Le Goanvic, C., Lionet, P., Pagis, B., Pasche, J., Roy, C., Vahanian, A., Papouin, G. Eur. Heart J. (2003) [Pubmed]
  29. Sera from patients with high titers of antibody to streptolysin O react with listeriolysin. Chatzipanagiotou, S., Hof, H. J. Clin. Microbiol. (1988) [Pubmed]
  30. Antibodies to penicillin in children receiving long-term secondary prophylaxis for rheumatic fever. Strannegård, I.L., Majeed, H.A., Ahlstedt, S. Allergy (1987) [Pubmed]
  31. Plasmapheresis in treatment of rheumatic fever. Shiokawa, Y., Yamagata, J. Jpn. Circ. J. (1980) [Pubmed]
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