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MeSH Review


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Disease relevance of Erysipelas

  • One lesion resembled erysipelas, which is quite common in familial Mediterranean fever, whereas the other was panniculitis, only occasionally described in familial Mediterranean fever [1].
  • Neutralization of SpeB was significantly lower in sera of patients with STSS than in sera from persons with bacteremia or erysipelas [2].
  • Distinct monoclonal antibodies obtained from rats suffering from erysipelas polyarthritis display a unique property by inducing very efficiently protective and regulatory mechanisms while being unable to generate classical "passive immunity". These "inductive" monoclonal antibodies recognize most likely linear epitopes on the purified glycoprotein [3].
  • The primary pattern of FMF is acute, self-resolving periodic attacks of high-grade fever, accompanied by either peritonitis, pleuritis, or arthritis and sometimes typical ankle rash that simulates erysipelas [4].

High impact information on Erysipelas


Chemical compound and disease context of Erysipelas


Anatomical context of Erysipelas

  • Neutralization of SpeA lymphocyte mitogenicity was totally absent in sera from patients with STSS and low in sera from persons with uncomplicated bacteremia compared with levels in sera from uncomplicated erysipelas [2].

Gene context of Erysipelas

  • The frequency of MRSA isolation suggests that beta-lactam antibiotics may not be sufficient for the treatment of bullous erysipelas anymore, at least in areas with a high incidence of MRSA strains [12].
  • Gross and histopathologic lesions were studied in 10 Broad-Breasted White turkeys with acute erysipelas induced experimentally [14].
  • Plasma fibronectin level in erysipelas [15].
  • An outbreak of erysipelas killed an estimated 5,000 aquatic birds on Great Salt Lake (Utah) in late November, 1975 [16].

Analytical, diagnostic and therapeutic context of Erysipelas

  • A prospective, randomized, multicentre trial was conducted to evaluate the efficacy and safety of roxithromycin (150 mg b.i.d. orally) and penicillin (2.5 MU x 8 daily intravenously, then 6 MU daily orally) in the treatment of hospitalized adult patients with erysipelas [5].


  1. Panniculitis in familial Mediterranean fever. Case report with histopathologic findings. Danar, D.A., Kwan, T.H., Stern, R.S., Kasdon, E.J., Birnbaum, P.S., Brown, R.S. Am. J. Med. (1987) [Pubmed]
  2. Invasive group A streptococcal infections: T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome. Eriksson, B.K., Andersson, J., Holm, S.E., Norgren, M. J. Infect. Dis. (1999) [Pubmed]
  3. Isolation of a high-molecular mass glycoprotein from culture supernatant of an arthritogenic strain of the bacteria Erysipelothrix rhusiopathiae reacting with "inductive" monoclonal antibodies derived from rats with erysipelas polyarthritis. Meier, B., Brunotte, C.M., Franz, B., Warlich, B., Petermann, M., Ziesenis, A., Schuberth, H.J., Habermehl, G.G., Petzoldt, K., Leibold, W. Biol. Chem. Hoppe-Seyler (1992) [Pubmed]
  4. Subtalar arthritis as a presenting symptom of Familial Mediterranean fever: case report and literature review. Dudkiewicz, I., Chechik, A., Blankstein, A., Salai, M. Acta orthopaedica Belgica. (2001) [Pubmed]
  5. Roxithromycin versus penicillin in the treatment of erysipelas in adults: a comparative study. Bernard, P., Plantin, P., Roger, H., Sassolas, B., Villaret, E., Legrain, V., Roujeau, J.C., Rezvani, Y., Scheimberg, A. Br. J. Dermatol. (1992) [Pubmed]
  6. Recurrent erysipelas caused by group B streptococcus organisms. Binnick, A.N., Klein, R.B., Baughman, R.D. Archives of dermatology. (1980) [Pubmed]
  7. Relapse of erysipelas following treatment with prednisolone or placebo in addition to antibiotics: a 1-year follow-up. Bergkvist, P.I., Sjöbeck, K. Scand. J. Infect. Dis. (1998) [Pubmed]
  8. First documented case of bacteremia with Vibrio vulnificus in Sweden. Melhus, A., Holmdahl, T., Tjernberg, I. Scand. J. Infect. Dis. (1995) [Pubmed]
  9. Skin concentrations of phenoxymethylpenicillin in patients with erysipelas. Sjöblom, A.C., Bruchfeld, J., Eriksson, B., Jorup-Rönström, C., Karkkonen, K., Malmborg, A.S., Lindqvist, M. Infection (1992) [Pubmed]
  10. Antibiotic and prednisolone therapy of erysipelas: a randomized, double blind, placebo-controlled study. Bergkvist, P.I., Sjöbeck, K. Scand. J. Infect. Dis. (1997) [Pubmed]
  11. Clinical results from the treatment of erysipelas with heparin. Iankova, R., Savova, J., Abadgieva, T., Teodosieva, E., Marina, S. Folia medica. (1995) [Pubmed]
  12. Bullous erysipelas: clinical presentation, staphylococcal involvement and methicillin resistance. Krasagakis, K., Samonis, G., Maniatakis, P., Georgala, S., Tosca, A. Dermatology (Basel) (2006) [Pubmed]
  13. Erysipelothrix tonsillarum isolated from dogs with endocarditis in Belgium. Takahashi, T., Tamura, Y., Yoshimura, H., Nagamine, N., Kijima, M., Nakamura, M., Devriese, L.A. Res. Vet. Sci. (1993) [Pubmed]
  14. Pathology of experimental erysipelas in turkeys. Bickford, A.A., Corstvet, R.E., Rosenwald, A.S. Avian Dis. (1978) [Pubmed]
  15. Plasma fibronectin level in erysipelas. Massoud, M.M., Mahmoud, B.A., Gadballa, M.R. The Journal of the Egyptian Public Health Association. (1990) [Pubmed]
  16. An outbreak of erysipelas in eared grebes (Podiceps nigricollis). Jensen, W.I., Cotter, S.E. J. Wildl. Dis. (1976) [Pubmed]
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