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Chemical Compound Review:

alpha-Dhpla 2-(3,4-dihydroxyphenyl)-2- hydroxy...

Synonyms: AG-E-65004, SureCN1805555, CTK4E9937, AKOS006320838, FT-0688301, ...

Ding, M. et al., Wang, C.Y. et al., Gu, M. et al., De-Eknamkul, W. et al., Zhao, F.Q. et al.

Gu, Wang, Su, Ouyang,

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High impact information on alpha-Dhpla

One-step separation and purification of 3,4-dihydroxyphenyllactic acid, salvianolic acid B and protocatechualdehyde from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography [1].
Anchusa PAT is not subject to feedback inhibition from L-phenylalanine or tyrosine, but its activity is affected by a rosmarinic acid metabolite, 3,4-dihydroxyphenyllactic acid [2].
Previous research has shown that salvianic acid A [2-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid, SA] extracted from Salvia miltiorrhiza BGE (Danshen) markedly inhibits lipid peroxidation of mitochondrial membrane of hepatic cells in vitro [3].
The present study demonstrated that extract of S. miltiorrhiza (ESM) and its major ingredients, Danshensu (DSS) and salvianolic acid B (Sal B), inhibited tumor necrosis factor (TNF-alpha) induced endothelial permeability, whereas the other major ingredient, protocatechualdehyde, was ineffective [4].
Pharmacokinetics of a Chinese traditional medicine, danshensu (3,4-dihydroxyphenyllactic acid), in rabbits using high-performance liquid chromatography [5].

References

One-step separation and purification of 3,4-dihydroxyphenyllactic acid, salvianolic acid B and protocatechualdehyde from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography. Gu, M., Wang, X., Su, Z., Ouyang, F. Journal of chromatography. A (2007) [Pubmed]
Purification and characterization of prephenate aminotransferase from Anchusa officinalis cell cultures. De-Eknamkul, W., Ellis, B.E. Arch. Biochem. Biophys. (1988) [Pubmed]
Protective effect of salvianic Acid a on acute liver injury induced by carbon tetrachloride in rats. Wang, C.Y., Ma, F.L., Liu, J.T., Tian, J.W., Fu, F.H. Biol. Pharm. Bull. (2007) [Pubmed]
Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-alpha. Ding, M., Ye, T.X., Zhao, G.R., Yuan, Y.J., Guo, Z.X. Int. Immunopharmacol. (2005) [Pubmed]
Pharmacokinetics of a Chinese traditional medicine, danshensu (3,4-dihydroxyphenyllactic acid), in rabbits using high-performance liquid chromatography. Zhao, F.Q., Zheng, N.X., Sato, H., Adachi, I., Horikoshi, I. Biol. Pharm. Bull. (1997) [Pubmed]

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