Protective effect of salvianic Acid a on acute liver injury induced by carbon tetrachloride in rats.
Previous research has shown that salvianic acid A [2-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid, SA] extracted from Salvia miltiorrhiza BGE (Danshen) markedly inhibits lipid peroxidation of mitochondrial membrane of hepatic cells in vitro. The present study was conducted to examine protective effect of SA on liver injury induced by carbon tetrachloride (CCl(4)) and its possible mechanism in vivo. Male Sprague-Dowley rats weighing 180-200 g were used in the experiments. Five mmol/kg CCl(4) in olive oil was given to rats i.p. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) as well as malondialdehyde (MDA) level in hepatic tissue and the rate of superoxide anion (O(2).(-)) generation in hepatic submitochondrial particles. Hepatic histological structure was observed under light microscopy. CCl(4) caused significant changes of activities of the enzymes, MDA level, and the rate of O(2).(-) generation and histopathological changes of acute hepatic injury were noted. SA reversed the significant changes induced by CCl(4). These results demonstrate that SA produces protective action on acute hepatic injury induced by CCl(4) via an antioxidative mechanism.[1]References
- Protective effect of salvianic Acid a on acute liver injury induced by carbon tetrachloride in rats. Wang, C.Y., Ma, F.L., Liu, J.T., Tian, J.W., Fu, F.H. Biol. Pharm. Bull. (2007) [Pubmed]
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