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Chemical Compound Review

Rosemary acid     3-(3,4-dihydroxyphenyl)-2- [(E)-3-(3,4...

Synonyms: SureCN19348, AC1NSTA2, CCRIS 9361, BSPBio_003595, CHEBI:17226, ...
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Disease relevance of NSC687846


Psychiatry related information on NSC687846

  • Rosmarinic acid (2 and 4 mg kg(-1)) increased the number of entries in the open arms, suggesting an anxiolytic-like activity when used in lower doses, without affecting the short-term memory (STM) and long-term memory (LTM) retention on inhibitory avoidance task [6].

High impact information on NSC687846


Chemical compound and disease context of NSC687846


Biological context of NSC687846


Anatomical context of NSC687846


Associations of NSC687846 with other chemical compounds

  • Rosmarinic acid concentrations up to 10,000 microM did not cause direct inactivation of C3 [12].
  • Hydroxyphenylpyruvate reductase (HPPR) is an enzyme involved in the biosynthesis of rosmarinic acid in Lamiaceae reducing hydroxyphenylpyruvates in dependence of NAD(P)H to the corresponding hydroxyphenyllactates [17].
  • The HPPR protein was purified from suspension cells of Coleus blumei accumulating high levels of rosmarinic acid by ammonium sulfate precipitation, anion exchange chromatography, hydroxylapatite chromatography, chromatography on 2',5'-ADP-Sepharose 4B and SDS-polyacrylamide gel electrophoresis [17].
  • Der f challenge also enhanced allergen-specific IgG1, which were also inhibited by rosmarinic acid in PE [16].
  • Inhibition of C5 convertase activity required 1500 microM rosmarinic acid, and no significant inhibition of the C3 convertase enzyme, which produces C3b from C3, was observed at 10,000 microM [12].

Gene context of NSC687846


Analytical, diagnostic and therapeutic context of NSC687846


  1. Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K., Kato, Y., Osawa, T., Yoshikawa, T. Free Radic. Biol. Med. (2003) [Pubmed]
  2. The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity. Iuvone, T., De Filippis, D., Esposito, G., D'Amico, A., Izzo, A.A. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  3. Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures. Bulgakov, V.P., Veselova, M.V., Tchernoded, G.K., Kiselev, K.V., Fedoreyev, S.A., Zhuravlev, Y.N. Planta (2005) [Pubmed]
  4. Suppressive effects of rosmarinic acid on mesangioproliferative glomerulonephritis in rats. Makino, T., Ono, T., Liu, N., Nakamura, T., Muso, E., Honda, G. Nephron (2002) [Pubmed]
  5. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). Renzulli, C., Galvano, F., Pierdomenico, L., Speroni, E., Guerra, M.C. Journal of applied toxicology : JAT. (2004) [Pubmed]
  6. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pereira, P., Tysca, D., Oliveira, P., da Silva Brum, L.F., Picada, J.N., Ardenghi, P. Pharmacol. Res. (2005) [Pubmed]
  7. Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity. Kang, M.A., Yun, S.Y., Won, J. Blood (2003) [Pubmed]
  8. Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. Hur, Y.G., Yun, Y., Won, J. J. Immunol. (2004) [Pubmed]
  9. Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation. Walker, T.S., Bais, H.P., Déziel, E., Schweizer, H.P., Rahme, L.G., Fall, R., Vivanco, J.M. Plant Physiol. (2004) [Pubmed]
  10. The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Salimei, P.S., Marf??, G., Di Renzo, L., Di Stefano, C., Giganti, M.G., Filomeni, G., Ciriolo, M.R. Front. Biosci. (2007) [Pubmed]
  11. Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. Mazumder, A., Neamati, N., Sunder, S., Schulz, J., Pertz, H., Eich, E., Pommier, Y. J. Med. Chem. (1997) [Pubmed]
  12. Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b. Sahu, A., Rawal, N., Pangburn, M.K. Biochem. Pharmacol. (1999) [Pubmed]
  13. Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3. Lee, J., Jung, E., Kim, Y., Lee, J., Park, J., Hong, S., Hyun, C.G., Park, D., Kim, Y.S. Br. J. Pharmacol. (2006) [Pubmed]
  14. Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells. Makino, T., Ono, T., Muso, E., Yoshida, H., Honda, G., Sasayama, S. Nephrol. Dial. Transplant. (2000) [Pubmed]
  15. Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells. Lee, H.J., Jeong, Y.I., Lee, T.H., Jung, I.D., Lee, J.S., Lee, C.M., Kim, J.I., Joo, H., Lee, J.D., Park, Y.M. Biochem. Pharmacol. (2007) [Pubmed]
  16. Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K.I., Sadakane, K., Ichinose, T., Yoshikawa, T. Clin. Exp. Allergy (2004) [Pubmed]
  17. Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. Kim, K.H., Janiak, V., Petersen, M. Plant Mol. Biol. (2004) [Pubmed]
  18. Inhibitory effects of rosmarinic acid on Lck SH2 domain binding to a synthetic phosphopeptide. Ahn, S.C., Oh, W.K., Kim, B.Y., Kang, D.O., Kim, M.S., Heo, G.Y., Ahn, J.S. Planta Med. (2003) [Pubmed]
  19. Simultaneous determination of magnesium lithospermate B, rosmarinic acid, and lithospermic acid in beagle dog serum by liquid chromatography/tandem mass spectrometry. Li, X., Yu, C., Sun, W., Liu, G., Jia, J., Wang, Y. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
  20. Automated post-collection concentration for purified preparative fractions via solid phase extraction. Stevens, J., Crawford, M., Robinson, G., Roenneburg, L. Journal of chromatography. A (2007) [Pubmed]
  21. Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis. Youn, J., Lee, K.H., Won, J., Huh, S.J., Yun, H.S., Cho, W.G., Paik, D.J. J. Rheumatol. (2003) [Pubmed]
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