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Chemical Compound Review

Sodium dioctyl sulfosuccinate     1,2-bis(octoxycarbonyl) ethanesulfonic acid

Synonyms: Manoxol, Solbaleite, Bu-cerumen, Butyl-cerumen, Empimin OT, ...
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High impact information on Sodium dioctyl sulfosuccinate

  • All the 16 PAHs were baseline-resolved using an optimized running buffer containing 22.5 mM DOSS, 15 mM SB-beta-CD, 15% acetonitrile and 5 mM hydroxypropyl-beta-cyclodextrin in 6 mM borate at pH 9 [1].
  • Sodium dioctyl sulfosuccinate (DOSS) displayed selectivities for PAHs which were somewhat similar to the C18 phase in reversed-phase high performance liquid chromatography (HPLC) [1].
  • The process is accompanied by an increase in the steady-state anisotropy, as opposed to what happens for denaturation in aqueous solution.Since 1-hexanol used as co-surfactant in dioctyl sulfosuccinate reverse micelles slows or even prevents cutinase denaturation, its effect on cutinase conformation and on the size of reverse micelles was analyzed [2].
  • This is attributed to a favourable stereoelectronic interaction between DSS and the nucleus of melatonin, which seems to be independent of the pH of the dissolution medium [3].
  • At pH 4.0, the transport of methotrexate was enhanced by the counter ions and a marked increase in the flux of the drug was measured when dodecyl sulfate and dioctyl sulfosuccinate were used [4].

Associations of Sodium dioctyl sulfosuccinate with other chemical compounds


  1. Mixed-mode separation of polycyclic aromatic hydrocarbons (PAHs) in electrokinetic chromatography. Luong, J.H., Guo, Y. Electrophoresis (1998) [Pubmed]
  2. Cutinase-AOT interactions in reverse micelles: the effect of 1-hexanol. Melo, E.P., Costa, S.M., Cabral, J.M., Fojan, P., Petersen, S.B. Chem. Phys. Lipids (2003) [Pubmed]
  3. Pineal hormone melatonin: solubilization studies in model aqueous gastrointestinal environments. Vlachou, M., Eikosipentaki, A., Xenogiorgis, V. Current drug delivery. (2006) [Pubmed]
  4. Influence of counter ions on the skin permeation of methotrexate from water--oil microemulsions. Trotta, M., Pattarino, F., Gasco, M.R. Pharmaceutica acta Helvetiae. (1996) [Pubmed]
  5. Measurement of superoxide dismutase-like activity of natural antioxidants. Kim, S.J., Han, D., Moon, K.D., Rhee, J.S. Biosci. Biotechnol. Biochem. (1995) [Pubmed]
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