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Chemical Compound Review

Docusate sodium     sodium1,2-bis(2- ethylhexoxycarbonyl)ethan...

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Disease relevance of Docusate sodium


High impact information on Docusate sodium


Chemical compound and disease context of Docusate sodium


Biological context of Docusate sodium

  • Sodium dioctyl sulfosuccinate (DOSS) or sodium di-2-ethylhexyl sulfosuccinate, a relatively nontoxic and negatively charged surfactant, was selected and optimized for the capillary electrophoretic separation of the 16 Environmental Protection Agency (EPA) priority polycyclic aromatic hydrocarbons (PAHs) [13].
  • Three modes of molecular recognition are indicated to be important: (1) active site molecular recognition; (2) recognition at an anion-recognition site which may be the active site, and; (3) interfacial (or hydrophobic) recognition which may be exploited to increase affinity for the anion-recognition site in anionic surfactants such as AOT [14].
  • The alpha-chymotrypsin-catalyzed hydrolysis of succinyl-L-alanyl-L-alanyl- L-prolyl-L-phenylalanyl p-nitroanilide has been studied in reverse micelles of sodium bis(2-ethylhexyl)sulfosuccinate (AOT) in isooctane [15].
  • Ionic compounds such as DOSS and GDCA have the greatest effect, and further studies of these classes of surface active agents for use as enhancers of alveolar absorption of pharmaceuticals seem warranted [16].
  • Alveolar surface tension was elevated by inhalation of 15 mg/kg of the aerosolized detergent dioctyl sodium sulfosuccinate (OT) [17].

Anatomical context of Docusate sodium


Associations of Docusate sodium with other chemical compounds


Gene context of Docusate sodium


Analytical, diagnostic and therapeutic context of Docusate sodium


  1. Dioctyl sodium sulphosuccinate in constipation. Clayden, G.S. Lancet (1978) [Pubmed]
  2. Regulation of the supramolecular structure and the catalytic activity of penicillin acylase from Escherichia coli in the system of reversed micelles of Aerosol OT in octane. Kabakov, V.E., Merker, S., Klyachko, N.L., Martinek, K., Levashov, A.V. FEBS Lett. (1992) [Pubmed]
  3. Microvascular membrane permeability in high surface tension pulmonary edema. Bredenberg, C.E., Nieman, G.F., Paskanik, A.M., Hart, A.K. J. Appl. Physiol. (1986) [Pubmed]
  4. Preclinical evaluation of docusate as protective agent from herpes simplex viruses. Gong, Y., Wen, A., Cheung, D., Wong, M., Sacks, S.L. Antiviral Res. (2001) [Pubmed]
  5. Allergic contact dermatitis from dioctyl sodium sulfosuccinate in a topical corticosteroid. Lee, A.Y., Lee, K.H. Contact Derm. (1998) [Pubmed]
  6. Effect of oral dioctyl sodium sulfosuccinate on intake-output studies of human small and large intestine. Chapman, R.W., Sillery, J., Fontana, D.D., Matthys, C., Saunders, D.R. Gastroenterology (1985) [Pubmed]
  7. pH-dependent substrate preference of pig heart lipoamide dehydrogenase varies with oligomeric state: response to mitochondrial matrix acidification. Klyachko, N.L., Shchedrina, V.A., Efimov, A.V., Kazakov, S.V., Gazaryan, I.G., Kristal, B.S., Brown, A.M. J. Biol. Chem. (2005) [Pubmed]
  8. Nonaqueous biocatalytic synthesis of new cytotoxic doxorubicin derivatives: exploiting unexpected differences in the regioselectivity of salt-activated and solubilized subtilisin. Altreuter, D.H., Dordick, J.S., Clark, D.S. J. Am. Chem. Soc. (2002) [Pubmed]
  9. Increasing peritoneal contact area during dialysis improves mass transfer. Flessner, M.F., Lofthouse, J., Williams, A. J. Am. Soc. Nephrol. (2001) [Pubmed]
  10. Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum. Moriarty, K.J., Kelly, M.J., Beetham, R., Clark, M.L. Gut (1985) [Pubmed]
  11. Acute mouse and chronic dog toxicity studies of danthron, dioctyl sodium sulfosuccinate, poloxalkol and combinations. Case, M.T., Smith, J.K., Nelson, R.A. Drug and chemical toxicology. (1977) [Pubmed]
  12. Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme. Klyachko, N.L., Vakula, S.V., Gladyshev, V.N., Tishkov, V.I., Levashov, A.V. Biochemistry Mosc. (1997) [Pubmed]
  13. The combined effect of acetonitrile and urea on the separation of polycyclic aromatic hydrocarbons using sodium dioctyl sulfosuccinate in electrokinetic chromatography. Luong, J.H. Electrophoresis (1998) [Pubmed]
  14. Inhibition of phosphatidylinositol-specific phospholipase C: studies on synthetic substrates, inhibitors and a synthetic enzyme. Vizitiu, D., Kriste, A.G., Campbell, A.S., Thatcher, G.R. J. Mol. Recognit. (1996) [Pubmed]
  15. Product inhibition of alpha-chymotrypsin in reverse micelles. Bru, R., Walde, P. Eur. J. Biochem. (1991) [Pubmed]
  16. Surface active agents as enhancers of alveolar absorption. Wollmer, P., Bäckström, K., Zhao, H., Nilsson, P.G., Jonson, B. Pharm. Res. (2000) [Pubmed]
  17. Positive end-expiratory pressure accelerates lung water accumulation in high surface tension edema. Nieman, G.F., Bredenberg, C.E., Paskanik, A.M. Surgery (1990) [Pubmed]
  18. Regulation of the catalytic activity and oligomeric composition of enzymes in reversed micelles of surfactants in organic solvents. Kabanov, A.A., Nametkin, S.N., Klyachko, N.L., Levashov, A.V. FEBS Lett. (1991) [Pubmed]
  19. Solubilization of rat kidney lysosomes in reversed micelles of aerosol OT in octane. Pshezhetsky, A.V., Buneeva, O.A., Wiederschain GYa, n.u.l.l. FEBS Lett. (1991) [Pubmed]
  20. Appearance of myelin forms in rheopexic dispersions of dioctyl sodium sulfosuccinate. Levinson, R.S., Allen, L.V., Vishnupad, K.S., Ecanow, B. Journal of pharmaceutical sciences. (1976) [Pubmed]
  21. Ceruminolytic effects of docusate sodium: a randomized, controlled trial. Singer, A.J., Sauris, E., Viccellio, A.W. Annals of emergency medicine. (2000) [Pubmed]
  22. Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum. Moriarty, K.J., Rolston, D.D., Kelly, M.J., Shield, M., Clark, M.L. Gut (1985) [Pubmed]
  23. Spectroscopic and kinetic studies of lipases solubilized in reverse micelles. Walde, P., Han, D., Luisi, P.L. Biochemistry (1993) [Pubmed]
  24. Kinetic mechanism of octopus hepatopancreatic glutathione transferase in reverse micelles. Tang, S.S., Chang, G.G. Biochem. J. (1996) [Pubmed]
  25. Dynamics of acrylodan-labeled bovine and human serum albumin sequestered within aerosol-OT reverse micelles. Lundgren, J.S., Heitz, M.P., Bright, F.V. Anal. Chem. (1995) [Pubmed]
  26. Effect of graded hydration on the dynamics of an ion channel peptide: a fluorescence approach. Kelkar, D.A., Chattopadhyay, A. Biophys. J. (2005) [Pubmed]
  27. Membrane proteins in reverse micelles: myelin basic protein in a membrane-mimetic environment. Nicot, C., Vacher, M., Vincent, M., Gallay, J., Waks, M. Biochemistry (1985) [Pubmed]
  28. Subunit separation in reversed micelle system reveals the existence of active centers both on light and heavy gamma-glutamyltransferase subunits. Kabanov, A.V., Nametkin, S.N., Chernov, N.N., Klyachko, N.L., Levashov, A.V. FEBS Lett. (1991) [Pubmed]
  29. Protective effects of small amounts of bis(2-ethylhexyl)sulfosuccinate on the helical structures of human and bovine serum albumins in their thermal denaturations. Moriyama, Y., Takeda, K. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  30. Micro-Raman investigations of myelins in aerosol-OT/water system. Arunagirinathan, M.A., Roy, M., Dua, A.K., Manohar, C., Bellare, J.R. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  31. An investigation of the factors controlling the adsorption of protein antigens to anionic PLG microparticles. Chesko, J., Kazzaz, J., Ugozzoli, M., O'hagan, D.T., Singh, M. Journal of pharmaceutical sciences. (2005) [Pubmed]
  32. Improving contact area between the peritoneum and intraperitoneal therapeutic solutions. Flessner, M.F., Lofthouse, J., Zakaria, E.R. J. Am. Soc. Nephrol. (2001) [Pubmed]
  33. Simultaneous high-pressure liquid chromatographic determination of niacin and niacinamide in multivitamin preparations: reversed-phase, ion-pairing approach. Sood, S.P., Wittmer, D.P., Ismaiel, S.A., Haney, W.G. Journal of pharmaceutical sciences. (1977) [Pubmed]
  34. Pressure-induced protein unfolding in the ternary system AOT-octane-water is different from that in bulk water. Meersman, F., Dirix, C., Shipovskov, S., Klyachko, N.L., Heremans, K. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  35. Dioctyl sodium sulphosuccinate increases net ultrafiltration in peritoneal dialysis. Wang, T., Qureshi, A.R., Heimbürger, O., Waniewski, J., Chen, C., Bergström, J., Lindholm, B. Nephrol. Dial. Transplant. (1997) [Pubmed]
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