Disease relevance of Ketogan

• Analgesic treatment in acute myocardial infarction. A double-blind comparison of ketobemidone + the spasmolytic A29 (Ketogan) and morphine [1].
• Analgetic effects of indomethacin (Confortid) compared to Ketogin in patients with acute cholecystitis [2].

High impact information on Ketogan

• One hundred female patients scheduled for elective breast surgery (mean age 60 +/- 11 years were randomly assigned to receive one of two premedications: ketobemidone (Ketogan) 1-1.5 ml or midazolam 4-5 mg, intramuscularly [3].
• Analgesic effect and bioavailability of oral ketogan given as tablets or mixture to patients with chronic pain of malignant origin [4].
• A qualitative GC-MS technique was demonstrated for the detection of the spasmolyticum A29 (N,N-dimethyl-4,4-diphenyl-3-buten-2-amine), which can be found in a preparation combined with ketobemidone (Ketogan) [5].
• Morphine caused a greater reduction of the systolic blood pressure than Ketogan [1].
• The analgesic effect of ketobemidone hydrochloride + the spasmolytic component A29 (Ketogan) and morphine hydrochloride was compared double-blindly in patients with suspect acute myocardial infarction [1].

Associations of Ketogan with other chemical compounds

• Plasma concentrations were determined following intravenous administration of Ketogin 2 ml, containing ketobemidone chloride 10 mg and the spasmolytic substance N, N-dimethyl-3, 3-diphenyl-l-methylallylamine chloride 50 mg and following oral or rectal administration of Ketogin [6].

Analytical, diagnostic and therapeutic context of Ketogan

• Thirteen cancer patients with moderate to severe chronic pain of malignant origin on treatment with Ketogan tablets were included in an open non-randomized cross-over study comparing the analgesic effect, side effects and serum concentrations of Ketogan tablets and mixture [4].
• For pain-score the difference was significant (p = 0.02) in arthrodesis/arthroplasty patients day 1 and for need for Ketogan injections (p less than 0.001) in all patients day 0 [7].

References