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Chemical Compound Review

PZ-Peptide     (2R)-5- (diaminomethylideneamino)-2- [[(2S)...

Synonyms: KST-1B1552, KST-1B1553, AC1L4OZV, AR-1B8502, AR-1B8503, ...
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Disease relevance of PZ-Peptide


High impact information on PZ-Peptide

  • However, if the active site was first blocked by the PZ-peptide and subsequently exposed to the (Pro-Pro-Gly)(5) peptide, the difference Fourier map was indistinguishable from that obtained with the PZ-peptide alone [2].
  • Moreover, Pz-peptide transport across Caco-2 cell monolayers could be titrated against mucosal Na+ concentration [3].
  • This study was conducted to demonstrate that Na+ played a role in the paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg (Pz-peptide), a hydrophilic proline-containing pentapeptide, across the rabbit colonic mucosa and Caco-2 cell monolayers [3].
  • Within this stretch was found PLGP, the amino acid sequence constituting the Pz peptide [4].
  • The purified enzyme was identified as the major collagenase of the organism, and it cleaved typical collagenase substrates such as azocoll, a synthetic substrate (4-phenylazobenzyloxy-carbonyl-Pro-Leu-Gly-Pro-D-Arg [Pz peptide]), and a type I collagen fibril [4].

Biological context of PZ-Peptide


Anatomical context of PZ-Peptide

  • Two peptidases hydrolyzing the Pz-peptide substrate were identified in bovine semen [7].
  • We have demonstrated previously that the Pz-peptide synthetic substrate is cleaved by two distinct spermatozoal peptidases, Pz-peptidases A and B. To facilitate further investigations, Pz-peptidase B was purified from bovine spermatozoa [5].
  • The cornea appeared to be more sensitive than the conjunctiva to the penetration enhancement effect of Pz-peptide [6].
  • Pz-peptide was extensively uptaked into hepatocytes [8].
  • Two PZ-peptidases (EC 3.4.-) (A and B) cleaving a synthetic substrate for collagenase, 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg (PZ-peptide) have been separated from the particulate fraction of bovine dental follicle [9].

Gene context of PZ-Peptide

  • The activator was isolated, partly purified, and shown to be thermolabile, nondialysable, and had no activity toward casein, haemoglobin, histones, and PZ-peptide [10].

Analytical, diagnostic and therapeutic context of PZ-Peptide

  • This method is based on the monitoring of the absorption at 320 nm of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu (PZ-Pro-Leu), enzymatically formed from the substrate 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg (PZ-peptide), after separation by high-performance liquid chromatography using a C18 reversed-phase column by isocratic elution [11].


  1. Proteolytic activity in black-pigmented bacteroides species. Jun, K.C., Barua, P.K., Zambon, J.J., Neiders, M.E. Journal of endodontics. (1989) [Pubmed]
  2. Binding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytes. Harris, D.L., King, E., Ramsland, P.A., Edmundson, A.B. J. Mol. Recognit. (2000) [Pubmed]
  3. Role of Na+ in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across rabbit colonic segments and Caco-2 cell monolayers. Yen, W.C., Lee, V.H. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  4. Purification and characterization of Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene. Matsushita, O., Yoshihara, K., Katayama, S., Minami, J., Okabe, A. J. Bacteriol. (1994) [Pubmed]
  5. Purification and characterization of Pz-peptidase B, a neutral metalloendopeptidase from bovine spermatozoa. Lessley, B.A., Garner, D.L. Biol. Reprod. (1990) [Pubmed]
  6. Ocular absorption of Pz-peptide and its effect on the ocular and systemic pharmacokinetics of topically applied drugs in the rabbit. Chung, Y.B., Han, K., Nishiura, A., Lee, V.H. Pharm. Res. (1998) [Pubmed]
  7. Identification and preliminary characterization of two distinct bovine seminal Pz-peptidases. Lessley, B.A., Garner, D.L. Biol. Reprod. (1984) [Pubmed]
  8. Extensive hepatic uptake of Pz-peptide, a hydrophilic proline-containing pentapeptide, into isolated hepatocytes compared with colonocytes and Caco-2 cells. Shin, T.H., Lee, P.S., Kwon, O.S., Chung, Y.B. Arch. Pharm. Res. (2003) [Pubmed]
  9. Separation of two PZ-peptidases from bovine dental follicle. Hino, M., Nagatsu, T. Biochim. Biophys. Acta (1976) [Pubmed]
  10. Activation of human leucocyte procollagenase by rheumatoid synovial tissue culture medium. Wize, J., Abgarowicz, T., Wojtecka-Lukasik, E., Ksiezny, S., Dancewicz, A.M. Ann. Rheum. Dis. (1975) [Pubmed]
  11. High-performance liquid chromatographic determination of PZ-peptidase activity. Chikuma, T., Tanaka, W., Yamada, K., Ishii, Y., Tanaka, A., Kato, T. J. Chromatogr. (1993) [Pubmed]
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