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MeSH Review

Dental Sac

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Disease relevance of Dental Sac


High impact information on Dental Sac

  • Transfecting short interfering RNA specific for CSF-1 mRNA into dental follicle cells resulted in an up-regulation of OPG expression [6].
  • In the rat first mandibular molar, a decrease in the expression of osteoprotegerin (OPG) in the dental follicle at day 3 enables the osteoclastogenesis needed for eruption to occur [6].
  • Treatment of the cells with phorbolmyristate acetate (PMA), a protein kinase C (PKC) activator, enhanced expression of the 2 major VEGF isoforms in the cultured dental follicle cells, whereas adding a specific PKC inhibitor prevented this [7].
  • Primary cells were obtained from mandibular bodies by enzymatic digestion and cultured in alphaMEM containing 15% FBS without any cytokine or growth factor or hormone in the culture (AFT culture, for alveolar bone, dental follicle, and tooth) [8].
  • Cbfa1 is also expressed at high levels by the dental follicle cells [9].

Chemical compound and disease context of Dental Sac


Biological context of Dental Sac


Anatomical context of Dental Sac


Associations of Dental Sac with chemical compounds


Gene context of Dental Sac


Analytical, diagnostic and therapeutic context of Dental Sac


  1. Cytokeratin expression of the odontogenic epithelia in dental follicles and developmental cysts. Gao, Z., Mackenzie, I.C., Cruchley, A.T., Williams, D.M., Leigh, I., Lane, E.B. J. Oral Pathol. Med. (1989) [Pubmed]
  2. Regulation of secretion of osteoprotegerin in rat dental follicle cells. Wise, G.E., Ding, D., Yao, S. Eur. J. Oral Sci. (2004) [Pubmed]
  3. The central odontogenic fibroma and the hyperplastic dental follicle: study with Picrosirius red and polarizing microscopy. Hirschberg, A., Buchner, A., Dayan, D. J. Oral Pathol. Med. (1996) [Pubmed]
  4. Ampicillin concentrations in human oral tissues following a single oral administration of lenampicillin. Akimoto, Y., Mochizuki, Y., Uda, A., Omata, H., Shibutani, J., Kaneko, K., Yamane, J., Fujii, A., Yamamoto, H. Gen. Pharmacol. (1991) [Pubmed]
  5. Radiographic and histological analysis of tooth eruption through calcium phosphate ceramics in the cat. Feinberg, S.E., Weisbrode, S.E., Heintschel, G. Arch. Oral Biol. (1989) [Pubmed]
  6. CSF-1 regulation of osteoclastogenesis for tooth eruption. Wise, G.E., Yao, S., Odgren, P.R., Pan, F. J. Dent. Res. (2005) [Pubmed]
  7. Expression of vascular endothelial growth factor in the dental follicle. Wise, G.E., Yao, S. Crit. Rev. Eukaryot. Gene Expr. (2003) [Pubmed]
  8. Development of a novel mouse osteoclast culture system including cells of mandibular body and erupting teeth. Suda, N., Kitahara, Y., Hammond, V.E., Ohyama, K. Bone (2003) [Pubmed]
  9. Cellular, molecular, and genetic determinants of tooth eruption. Wise, G.E., Frazier-Bowers, S., D'Souza, R.N. Crit. Rev. Oral Biol. Med. (2002) [Pubmed]
  10. The cytology of the dental follicle and adjacent alveolar bone during tooth eruption in the dog. Marks, S.C., Cahill, D.R., Wise, G.E. Am. J. Anat. (1983) [Pubmed]
  11. Synthesis and secretion of MCP-1 by dental follicle cells--implications for tooth eruption. Wise, G.E., Que, B.G., Huang, H. J. Dent. Res. (1999) [Pubmed]
  12. Tooth eruption molecules enhance MCP-1 gene expression in the dental follicle of the rat. Que, B.G., Wise, G.E. Dev. Dyn. (1998) [Pubmed]
  13. Calbindin-D28 kappa localization in rat molars during odontogenesis. Elms, T.N., Taylor, A.N. J. Dent. Res. (1987) [Pubmed]
  14. Confocal laser scanning microscopic study [corrected] of tartrate-resistant acid phosphatase-positive cells in the dental follicle during early morphogenesis of mouse embryonic molar teeth. Sakakura, Y., Yajima, T., Tsuruga, E. Arch. Oral Biol. (1998) [Pubmed]
  15. Characterization of dental follicle cells in developing mouse molar. Hou, L.T., Liu, C.M., Chen, Y.J., Wong, M.Y., Chen, K.C., Chen, J., Thomas, H.F. Arch. Oral Biol. (1999) [Pubmed]
  16. Localization and expression of CSF-1 receptor in rat dental follicle cells. Wise, G.E., Zhao, L., Grier, R.L. J. Dent. Res. (1997) [Pubmed]
  17. Transcription and translation of CSF-1 in the dental follicle. Wise, G.E., Lin, F., Zhao, L. J. Dent. Res. (1995) [Pubmed]
  18. Expression of class 3 semaphorins and neuropilin receptors in the developing mouse tooth. Løes, S., Kettunen, P., Kvinnsland, I.H., Taniguchi, M., Fujisawa, H., Luukko, K. Mech. Dev. (2001) [Pubmed]
  19. Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation. Luukko, K., Saarma, M., Thesleff, I. Dev. Dyn. (1998) [Pubmed]
  20. Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro. Morsczeck, C. Calcif. Tissue Int. (2006) [Pubmed]
  21. Cellular events at the onset of physiological root resorption in rabbit deciduous teeth. Sahara, N. Anat. Rec. (2001) [Pubmed]
  22. The ontogeny of substance P--containing nerve fibres in the developing mouse dentition. Mohamed, S.S., Atkinson, M.E. Anat. Embryol. (1982) [Pubmed]
  23. Ampicillin concentrations in human serum, gingiva, the mandibular bone, and dental follicle following a single oral administration. Akimoto, Y., Nishimura, H., Komiya, M., Shibata, T., Kaneko, K., Fujii, A., Tamura, T. Gen. Pharmacol. (1985) [Pubmed]
  24. Cefaclor concentrations in human serum, gingiva, mandibular bone, and dental follicle following a single oral administration. Akimoto, Y., Mochizuki, Y., Uda, A., Omata, H., Shibutani, J., Nishimura, H., Komiya, M., Kaneko, K., Fujii, A. Gen. Pharmacol. (1992) [Pubmed]
  25. Differential regulation of TIMP-1, -2, and -3 mRNA and protein expressions during mouse incisor development. Yoshiba, N., Yoshiba, K., Stoetzel, C., Perrin-Schmitt, F., Cam, Y., Ruch, J.V., Hosoya, A., Ozawa, H., Lesot, H. Cell Tissue Res. (2006) [Pubmed]
  26. In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption. Yao, S., Wise, G. Connect. Tissue Res. (2004) [Pubmed]
  27. Inhibition of osteoclastogenesis by the secretion of osteoprotegerin in vitro by rat dental follicle cells and its implications for tooth eruption. Wise, G.E., Yao, S., Zhang, Q., Ren, Y. Arch. Oral Biol. (2002) [Pubmed]
  28. Epidermal growth factor and epidermal growth factor-receptor expression in the mouse dental follicle during tooth eruption. Shroff, B., Kashner, J.E., Keyser, J.D., Hebert, C., Norris, K. Arch. Oral Biol. (1996) [Pubmed]
  29. Purification and characterization of tripeptide aminopeptidase from bovine dental follicles. Hiraoka, B.Y., Harada, M. Mol. Cell. Biochem. (1993) [Pubmed]
  30. In vivo expression of RANKL in the rat dental follicle as determined by laser capture microdissection. Yao, S., Ring, S., Henk, W.G., Wise, G.E. Arch. Oral Biol. (2004) [Pubmed]
  31. Immunoexpression of epidermal growth factor in odontogenesis of the offspring of alcoholic mice. Hernández Guerrero, J.C., Portilla Robertson, J., Ledezma Montes, C., Ponce-Bravo, S., Miranda Gómez, A., Arias Rivera, E.M. Boletín de estudios médicos y biológicos. (1996) [Pubmed]
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