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Chemical Compound Review

Aloenin     6-[4-hydroxy-2-methyl-6- [(2S,3R,4S,5S,6R)...

Synonyms: Aloenin A, AG-F-35450, MEGxp0_001070, CTK8F7666, ZINC06070013, ...
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High impact information on Aloenin

  • The cytotoxic effects on HCT 116, Hep G2 and HCT 116/VCR 100-1-1 cell lines of synthetic 4'-O-alkylaloenins (2-17), 4'-O-benzylaloenin (18) and 4'-O-allylaloenin (19) were examined by MTT assay, and compared with that of aloenin (1) isolated from Aloe arborescens Mill [1].
  • The aim of the studies was to evaluate the permeability of biologically active aloe substances, determined as aloenin, through synthetic lipophilic and hydrophilic membranes in a standard perfusion apparatus and in vitro verification of the transport possibilities of these substances through the isolated cornea of pig's eye [2].
  • The permeability process of biologically active aloe substances determined as aloenin, through synthetic lipophilic and hydrophilic membranes, was analyzed using the first-order kinetics [2].
  • Biotransformation of aloenin, a bitter glucoside constituent of Aloe arborescens, by rats [3].
  • Aloenin has been established to be 4-methoxy-6-(2-beta-D-glucopyranosyloxy-4-hydroxy-6-methylphenyl)-2-pyrone; it shows an inhibitory activity for gastric juice secretion [3].

Analytical, diagnostic and therapeutic context of Aloenin


  1. 4'-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells. Jin, G.Z., Quan, H.J., Koyanagi, J., Takeuchi, K., Miura, Y., Komada, F., Saito, S. Cancer Lett. (2005) [Pubmed]
  2. Biopharmaceutical assessment of eye drops containing aloe (Aloe arborescens Mill.) and neomycin sulphate. Kodym, A., Grześkowiak, E., Partyka, D., Marcinkowski, A., Kaczyńska-Dyba, E. Acta poloniae pharmaceutica. (2002) [Pubmed]
  3. Biotransformation of aloenin, a bitter glucoside constituent of Aloe arborescens, by rats. Hirata, T., Sakano, S., Suga, T. Experientia (1981) [Pubmed]
  4. Gas chromatographic and mass spectral determination of aloenin in skin-care cosmetics. Nakamura, H., Okuyama, T. J. Chromatogr. (1990) [Pubmed]
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