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Chemical Compound Review

AG-K-97011     3-methylideneindole

Synonyms: SureCN5488008, CHEBI:63905, HMDB11664, CTK1D7190, AR-1F4460, ...
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Disease relevance of 3-methyleneindole


High impact information on 3-methyleneindole


Chemical compound and disease context of 3-methyleneindole


Gene context of 3-methyleneindole


Analytical, diagnostic and therapeutic context of 3-methyleneindole


  1. Detection and characterization of DNA adducts of 3-methylindole. Regal, K.A., Laws, G.M., Yuan, C., Yost, G.S., Skiles, G.L. Chem. Res. Toxicol. (2001) [Pubmed]
  2. Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene. Wang, H., Lanza, D.L., Yost, G.S. Arch. Biochem. Biophys. (1998) [Pubmed]
  3. Association of 3-methyleneindolenine, a toxic metabolite of 3-methylindole, with acute interstitial pneumonia in feedlot cattle. Loneragan, G.H., Gould, D.H., Mason, G.L., Garry, F.B., Yost, G.S., Lanza, D.L., Miles, D.G., Hoffman, B.W., Mills, L.J. Am. J. Vet. Res. (2001) [Pubmed]
  4. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. Thornton-Manning, J., Appleton, M.L., Gonzalez, F.J., Yost, G.S. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  5. Mechanistic studies on the cytochrome P450-catalyzed dehydrogenation of 3-methylindole. Skiles, G.L., Yost, G.S. Chem. Res. Toxicol. (1996) [Pubmed]
  6. 3-methylindole-induced toxicity to human bronchial epithelial cell lines. Nichols, W.K., Mehta, R., Skordos, K., Macé, K., Pfeifer, A.M., Carr, B.A., Minko, T., Burchiel, S.W., Yost, G.S. Toxicol. Sci. (2003) [Pubmed]
  7. Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes. Lanza, D.L., Yost, G.S. Drug Metab. Dispos. (2001) [Pubmed]
  8. Production and characterization of specific antibodies: utilization to predict organ- and species-selective pneumotoxicity of 3-methylindole. Kaster, J.K., Yost, G.S. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
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