Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Medebiotin 5-[(1S,2S,5S)-7-oxo-3-thia- 6,8...

Synonyms: Biotinum, Biotina, Biotine, Meribin, Bioepiderm, ...

Kang, Y.S. et al., Robinson, B.H. et al., Hopper, J.E. et al., Rasmussen, M.V. et al., Brown, R. et al., et al.

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Psychiatry related information on vitamin H

Exogenous administration of FS and related muramyl peptides results in an increase in slow-wave sleep (SWS) [1].

High impact information on vitamin H

Of the French presentation patients, five showed very low or absent 3H-biotin protein, streptavidin protein, and anti-PC precipitable protein at 125 kilodaltons [2].
As a control for the assessment of renal tubular function and the excretion of low molecular weight proteins in SLE patients, longitudinal measurements of beta-2-microglobulin (B2M) and lysozyme were made using a novel solid-phase 3H-biotin RIA technique [3].
The bifunctional nature of the conjugate was retained: the cHSA/NLA conjugate contained 2.8 to 6.8 biotin binding sites per conjugate, and the BBB permeability-surface area (PS) product for 3H-biotin bound to cHSA/NLA was at least 7-fold greater than the BBB PS product for 3H-biotin bound to a conjugate of NLA and native HSA (nHSA) [4].
Since the cationic nature of avidin (AV) accelerates the removal of avidin-based conjugates from blood in vivo, the present studies also describe the preparation and the pharmacokinetics of 3H-biotin bound to a conjugate of cHSA and neutral avidin (NLA) [4].
The increased area under the plasma concentration curve (AUC) of the cHSA-NLA conjugate correlated with an increase in brain delivery of 3H-biotin as compared to the brain delivery achieved with the cHSA/AV conjugate.(ABSTRACT TRUNCATED AT 250 WORDS)[4]

Anatomical context of vitamin H

Cultured skin fibroblasts from 16 patients with either French or American pyruvate carboxylase (PC) deficiency were examined for their ability to incorporate 3H-biotin into proteins [2].
To characterize the effects of dose and timing on high-affinity binding site mediated sequestration of specific chemical ligands in the gastrointestinal tract, avidin was perorally-administered to mice either prior to or mixed with 3H-biotin [5].
FS is derived from the bacterial cell wall and accumulates in the brain and body fluids of sleep-deprived animals including man [1].

Associations of vitamin H with other chemical compounds

The BioB-dependent conversion of dethiobiotin to biotin proceeded in these cells irrespective of the presence or absence of PLP [6].

References

Are antibiotic effects on sleep behavior in the rat due to modulation of gut bacteria? Brown, R., Price, R.J., King, M.G., Husband, A.J. Physiol. Behav. (1990) [Pubmed]
The French and North American phenotypes of pyruvate carboxylase deficiency, correlation with biotin containing protein by 3H-biotin incorporation, 35S-streptavidin labeling, and Northern blotting with a cloned cDNA probe. Robinson, B.H., Oei, J., Saudubray, J.M., Marsac, C., Bartlett, K., Quan, F., Gravel, R. Am. J. Hum. Genet. (1987) [Pubmed]
Clinical relapse in systemic lupus erythematosus: correlation with antecedent elevation of urinary free light-chain immunoglobulin. Hopper, J.E., Sequeira, W., Martellotto, J., Papagiannes, E., Perna, L., Skosey, J.L. J. Clin. Immunol. (1989) [Pubmed]
Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin. Kang, Y.S., Pardridge, W.M. Pharm. Res. (1994) [Pubmed]
High affinity binding site-mediated prevention of chemical absorption across the gastrointestinal tract. Rasmussen, M.V., Barker, T.T., Silbart, L.K. Toxicol. Lett. (2001) [Pubmed]
In vivo resolution of conflicting in vitro results: synthesis of biotin from dethiobiotin does not require pyridoxal phosphate. Abdel-Hamid, A.M., Cronan, J.E. Chem. Biol. (2007) [Pubmed]

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