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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Medebiotin     5-[(1S,2S,5S)-7-oxo-3-thia- 6,8...

Synonyms: Biotinum, Biotina, Biotine, Meribin, Bioepiderm, ...
 
 
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Psychiatry related information on vitamin H

  • Exogenous administration of FS and related muramyl peptides results in an increase in slow-wave sleep (SWS) [1].
 

High impact information on vitamin H

  • Of the French presentation patients, five showed very low or absent 3H-biotin protein, streptavidin protein, and anti-PC precipitable protein at 125 kilodaltons [2].
  • As a control for the assessment of renal tubular function and the excretion of low molecular weight proteins in SLE patients, longitudinal measurements of beta-2-microglobulin (B2M) and lysozyme were made using a novel solid-phase 3H-biotin RIA technique [3].
  • The bifunctional nature of the conjugate was retained: the cHSA/NLA conjugate contained 2.8 to 6.8 biotin binding sites per conjugate, and the BBB permeability-surface area (PS) product for 3H-biotin bound to cHSA/NLA was at least 7-fold greater than the BBB PS product for 3H-biotin bound to a conjugate of NLA and native HSA (nHSA) [4].
  • Since the cationic nature of avidin (AV) accelerates the removal of avidin-based conjugates from blood in vivo, the present studies also describe the preparation and the pharmacokinetics of 3H-biotin bound to a conjugate of cHSA and neutral avidin (NLA) [4].
  • The increased area under the plasma concentration curve (AUC) of the cHSA-NLA conjugate correlated with an increase in brain delivery of 3H-biotin as compared to the brain delivery achieved with the cHSA/AV conjugate.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
 

Anatomical context of vitamin H

  • Cultured skin fibroblasts from 16 patients with either French or American pyruvate carboxylase (PC) deficiency were examined for their ability to incorporate 3H-biotin into proteins [2].
  • To characterize the effects of dose and timing on high-affinity binding site mediated sequestration of specific chemical ligands in the gastrointestinal tract, avidin was perorally-administered to mice either prior to or mixed with 3H-biotin [5].
  • FS is derived from the bacterial cell wall and accumulates in the brain and body fluids of sleep-deprived animals including man [1].
 

Associations of vitamin H with other chemical compounds

  • The BioB-dependent conversion of dethiobiotin to biotin proceeded in these cells irrespective of the presence or absence of PLP [6].

References

 
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