Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

PubChem10770 1,2-dichloro-3-nitro-benzene

Synonyms: SureCN58157, AGN-PC-00GTW6, CHEMBL168024, ACMC-1CCAW, CCRIS 5901, ...

Sharer, J.E. et al., Gilhar, A. et al., Klein, P.J. et al.

Gilhar, Ullmann, Kalish, Berkutski, Azizi, Bank,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC60641

Recently we encountered a patient (p1) with a Clark's level IV melanoma associated with recurrent cutaneous metastasis who subsequently experienced a complete remission after a period of therapy with dichloronitrobenzene (DCNB) and interferon-alpha (IFNalpha) [1].

High impact information on NSC60641

Cytosol prepared from turkey livers exhibited GST-mediated conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) and 3,4-dichloronitrobenzene (DCNB), but at a much lower rate than that observed in other species [2].
Dog subcellular fractions showed higher activity than humans for midazolam 1'-hydroxylase, erythromycin N-demethylase, acetaminophen UDP-glucuronosyltransferase, acetaminophen sulfotransferase, 17 alpha-ethinylestradiol sulfotransferase, and DCNB glutathione S-transferase [3].

References

Favourable melanoma prognosis associated with the expression of the tumour necrosis factor receptor and the alpha1beta1 integrin: a preliminary report. Gilhar, A., Ullmann, Y., Kalish, R.S., Berkutski, T., Azizi, E., Bank, I. Melanoma Res. (1997) [Pubmed]
Biochemical basis for the extreme sensitivity of turkeys to aflatoxin B(1). Klein, P.J., Buckner, R., Kelly, J., Coulombe, R.A. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. Sharer, J.E., Shipley, L.A., Vandenbranden, M.R., Binkley, S.N., Wrighton, S.A. Drug Metab. Dispos. (1995) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share