Chemical Compound Review:
CHEMBL304858 (4-bromophenyl)-[2-fluoro-4- [6-(methyl...
Synonyms:
AG-K-30746, SureCN3674881, CHEBI:202549, KST-1A2406, CTK4E0060, ...
- Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse. Clarke, G.A., Bouchard, G., Paigen, B., Carey, M.C. Gut (2004)
- Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin. Peffley, D.M., Gayen, A.K., Morand, O.H. Biochem. Pharmacol. (1998)
- The monotopic membrane protein human oxidosqualene cyclase is active as monomer. Ruf, A., Müller, F., D'Arcy, B., Stihle, M., Kusznir, E., Handschin, C., Morand, O.H., Thoma, R. Biochem. Biophys. Res. Commun. (2004)