Gene Review:
Lith1 - lithogenic gene 1
Mus musculus
- Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice. Wittenburg, H., Lammert, F., Wang, D.Q., Churchill, G.A., Li, R., Bouchard, G., Carey, M.C., Paigen, B. Physiol. Genomics (2002)
- Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. Wang, D.Q., Paigen, B., Carey, M.C. J. Lipid Res. (1997)
- Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Maurer, K.J., Ihrig, M.M., Rogers, A.B., Ng, V., Bouchard, G., Leonard, M.R., Carey, M.C., Fox, J.G. Gastroenterology (2005)
- Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice. Hyogo, H., Roy, S., Cohen, D.E. J. Lipid Res. (2003)
- Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study. Maurer, K.J., Rogers, A.B., Ge, Z., Wiese, A.J., Carey, M.C., Fox, J.G. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Changes in bile composition during gallstone formation in hamsters. Yanaura, S., Iizuka, A. J. Pharmacobio-dyn. (1981)
- Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. Wang, D.Q., Schmitz, F., Kopin, A.S., Carey, M.C. J. Clin. Invest. (2004)
- Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones. Amigo, L., Castro, J., Miquel, J.F., Zanlungo, S., Young, S., Nervi, F. Gastroenterology (2006)
- Cholesterol Gallstone Susceptibility Loci: A Mouse Map, Candidate Gene Evaluation, and Guide to Human LITH Genes. Lyons, M.A., Wittenburg, H. Gastroenterology (2006)
- Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes. Lammert, F., Wang, D.Q., Paigen, B., Carey, M.C. J. Lipid Res. (1999)
- Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstones. Wang, H.H., Afdhal, N.H., Wang, D.Q. Gastroenterology (2004)
- Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse. Clarke, G.A., Bouchard, G., Paigen, B., Carey, M.C. Gut (2004)
- Differential effects of ursodeoxycholic acid and ursocholic acid on the formation of biliary cholesterol crystals in mice. Uchida, K., Akiyoshi, T., Igimi, H., Takase, H., Nomura, Y., Ishihara, S. Lipids (1991)
- The prevention of experimental cholesterol gallstones by ileectomy in mice. Yamamoto, T., Yamamoto, M., Ohyanagi, H., Saitoh, Y., Akiyoshi, T., Uchida, K. The Japanese journal of surgery. (1988)
- Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Khanuja, B., Cheah, Y.C., Hunt, M., Nishina, P.M., Wang, D.Q., Chen, H.W., Billheimer, J.T., Carey, M.C., Paigen, B. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Wittenburg, H., Lyons, M.A., Li, R., Kurtz, U., Mössner, J., Churchill, G.A., Carey, M.C., Paigen, B. Mamm. Genome (2005)
- Genetic analysis of cholesterol gallstone formation: searching for Lith (gallstone) genes. Wang, D.Q., Afdhal, N.H. Current gastroenterology reports. (2004)
- Biliary cholesterol hypersecretion in gallstone-susceptible mice is associated with hepatic up-regulation of the high-density lipoprotein receptor SRBI. Fuchs, M., Ivandic, B., Müller, O., Schalla, C., Scheibner, J., Bartsch, P., Stange, E.F. Hepatology (2001)
- DNA synthesis, cell proliferation index in normal and abnormal gallbladder epithelium. Lamote, J., Willems, G. Microsc. Res. Tech. (1997)
- Morphological alterations in epithelial cells of the mouse gallbladder 30 hours after treatment with lithogenic diet. Ziegler, U., Palme, G., Merker, H.J. Pathol. Res. Pract. (1982)
- Alterations in hepatocytes of mice fed a gallstone-inducing diet: occurrence of nuclear and cytoplasmic lipids. Saland, L.C., Napolitano, L.M. Anat. Rec. (1979)
- Synthesis of glycoproteins in the Golgi complex of the mouse gallbladder epithelium during fasting, refeeding, and gallstone formation. A light microscopic autoradiographic and quantitative electron microscopic study. Wahlin, T. Histochemistry (1977)
- Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. Figge, A., Lammert, F., Paigen, B., Henkel, A., Matern, S., Korstanje, R., Shneider, B.L., Chen, F., Stoltenberg, E., Spatz, K., Hoda, F., Cohen, D.E., Green, R.M. J. Biol. Chem. (2004)
- Effect of Beta-sitosterol on cholesterol-cholic acid-induced gallstone formation in mice. Goswami, S.K., Frey, C.F. Am. J. Gastroenterol. (1976)
- Review: pathogenesis of gallstones. Dowling, R.H. Aliment. Pharmacol. Ther. (2000)
- Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones. Henkel, A., Wei, Z., Cohen, D.E., Green, R.M. Mamm. Genome (2005)
- Cholelithiasis: genetic hypothesis. Sanchez-Mete, L., Attili, A.F. Minerva gastroenterologica e dietologica. (2000)
- Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice. Amigo, L., Mardones, P., Ferrada, C., Zanlungo, S., Nervi, F., Miquel, J.F., Rigotti, A. Hepatology (2003)
- Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice. Müller, O., Schalla, C., Scheibner, J., Stange, E.F., Fuchs, M. Biochem. J. (2002)
- Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice. Wu, M.K., Cohen, D.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-BI. Wang, D.Q., Carey, M.C. Biochim. Biophys. Acta (2002)
- Different susceptibilities to the formation of cholesterol gallstones in mice. Alexander, M., Portman, O.W. Hepatology (1987)
- Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice. Lammert, F., Wang, D.Q., Wittenburg, H., Bouchard, G., Hillebrandt, S., Taenzler, B., Carey, M.C., Paigen, B. Hepatology (2002)
- Effects of gallstone-promoting diet and vagotomy on the mouse gallbladder epithelium. Axelsson, H.G. Hepatogastroenterology (1999)
- Effects of fatty acid bile acid conjugates (FABACs) on biliary lithogenesis: Ppotential consequences for non-surgical treatment of gallstones. Konikoff, F.M., Gilat, T. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2005)
- Biliary proteins from hepatic bile of rats fed curcumin or capsaicin inhibit cholesterol crystal nucleation in supersaturated model bile. Hussain, M.S., Chandrasekhara, N. Indian J. Biochem. Biophys. (1994)