Disease relevance of Alphazurine

• OBJECTIVE: To report intense green hyperpigmentation related to FD & C Blue No. 1. DESIGN: Retrospective case review [1].
• Risk factors and mechanisms of FD&C Blue No. 1 toxicity are discussed, and alternate approaches to gastric aspiration detection in critically ill patients are considered [2].
• Food Drug and Cosmetic Blue No. 1 dye (FD&C Blue No. 1) is commonly added to enteral nutrition formulations in order to facilitate the detection of gastric aspirate in tracheal secretions of critically ill patients [2].
• We report two cases of abnormal systemic absorption of FD&C Blue No. 1 in critically ill patients who subsequently died of refractory shock and metabolic acidosis [2].
• The purpose of this prospective study was to determine if fiberoptic endoscopic evaluation of swallowing (FEES) maintains high intra- and interrater reliability in detecting pharyngeal dysphagia and aspiration without the addition of FD&C Blue No. 1 to food [3].

High impact information on Alphazurine

• STUDY OBJECTIVE: To determine the extent to which a mixture of human gastric juice and enteral formula stained with two concentrations of FD&C Blue No. 1 food dye (0.8 and 1.5 mL/L) is visible in suctioned tracheobronchial secretions following three forced small-volume pulmonary aspirations over a 6-h period in an animal model [4].

Chemical compound and disease context of Alphazurine

• Lifetime toxicity/carcinogenicity studies of FD & C Blue No. 1 (brilliant blue FCF) in rats and mice [5].

Analytical, diagnostic and therapeutic context of Alphazurine

• Methods are described for the determination of leuco base in FD&C Blue No. 1 by reverse phase liquid chromatography and for the preparation and standardization of leuco base stock solution [6].
• FD&C Blue No. 1 should be considered in the differential diagnosis of dark green discolored urine [7].

References