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Chemical Compound Review

Arofuto     6-amino-2-(fluoromethyl)-3- (2...

Synonyms: Afloqualon, Afloqualona, Aroft, afloqualone, Afloqualonum, ...
 
 
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Disease relevance of Arofuto

 

Psychiatry related information on Arofuto

 

High impact information on Arofuto

 

Analytical, diagnostic and therapeutic context of Arofuto

  • The disposition and metabolism of afloqualone [6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone, AFQ] were studied in monkeys and dogs after oral administration of 14C-AFQ [6].

References

  1. Phototoxic potential of afloqualone, a quinazolinone derivative, as determined by photosensitized inactivation of bacteriophage. Fujita, H., Matsuo, I. Chem. Biol. Interact. (1987) [Pubmed]
  2. Fixed drug eruption due to afloqualone: the first reported case. Demitsu, T., Tomita, Y. J. Dermatol. (1998) [Pubmed]
  3. Comparative effects on psychomotor performance of the muscle relaxant afloqualone, alone and with ethanol. Girre, C., Bertaux, L., Dussaucy, E., Palombo, S., Crouzette, J., Fournier, P.E. Fundamental & clinical pharmacology. (1991) [Pubmed]
  4. Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s). Kaji, H., Kume, T. Drug Metab. Dispos. (2005) [Pubmed]
  5. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Kudo, Y., Ishida, R. Jpn. J. Pharmacol. (1989) [Pubmed]
  6. Metabolism of afloqualone, a new centrally acting muscle relaxant, in monkeys and dogs. Otsuka, M., Furuuchi, S., Usuki, S., Nitta, S., Harigaya, S. J. Pharmacobio-dyn. (1983) [Pubmed]
 
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