Disease relevance of Vestibular Nucleus, Lateral

• (1) Electrical stimulation of the lateral vestibular nucleus (LVN) facilitated lordosis reflex responses to somatosensory stimulation, in estrogen-primed female rats [1].
• Chronic thiamine deprivation in the rat leads to ataxia, loss of righting reflex and neuropathological damage to lateral vestibular nucleus [2].
• Neurons isolated from the lateral vestibular nucleus of young adult and senescent Fischer-344 rats were incubated with fluorescamine-labelled Concanavalin A (fl-Con A) alone, or following incubation in trypsin or Vibrio cholerae neuraminidase [3].

High impact information on Vestibular Nucleus, Lateral

• Inhibitory effects of motilin, somatostatin, [Leu]enkephalin, [Met]enkephalin, and taurine on neurons of the lateral vestibular nucleus: interactions with gamma-aminobutyric acid [4].
• Protracted postural asymmetry occurred only if complete hemicerebellectomy included ablation of the lateral vestibular nucleus and extended for at least 3.0 mm across the midline into the contralateral vermal and intermediate cortex, especially of Larsell's lobuli IV and V [5].
• Glycine change was primarily limited to a bilateral decrease in the dorsal part of the lateral vestibular nucleus [6].
• In addition, the compounds also enhance the inhibitory effect of GABA ergic long projection neurones in the substantia nigra and the lateral vestibular nucleus of Deiters [7].
• In contrast, labyrinth ablation did not affect Narp staining in Deiters' nucleus or the flocculonodular lobe of the cerebellum, presumably because these areas are driven by inputs from multiple systems [8].

Biological context of Vestibular Nucleus, Lateral

• Energy metabolism in the lateral vestibular nucleus in pyrithiamin-induced thiamin deficiency [9].

Anatomical context of Vestibular Nucleus, Lateral

• An increase in cytochrome oxidase activity in the deep cerebellar nuclei and in some cerebellar efferent regions, such as the lateral vestibular nucleus, the parvicellular red nucleus, and the ventral tegmental area, was found in staggerer mutant mice [10].
• Single plasma membranes were microdissected from Deiters' neurons freshly obtained from the lateral vestibular nucleus of the rabbit and their chloride permeability was studied in a microchamber system [11].
• Immunostaining was confined to axon terminals, particularly in hippocampal and cerebellar mossy fibres and in Purkinje cell axonal terminations of the cerebellar deep nuclei and lateral vestibular nucleus [12].
• These results indicate that from the cervical spinal cord, [3H]choline selectively retrogradely labels a certain population of non-monaminergic, acetylcholinesterase-positive cells localized in the medial medullary, and secondarily the dorsolateral pontine, reticular formation, the lateral vestibular nucleus, and the red nucleus [13].
• Calbindin- and parvalbumin-positive terminals, but not calretinin-positive terminals, were present in the neuropil of the dorsal lateral vestibular nucleus, especially surrounding the large neuronal somas [14].

Associations of Vestibular Nucleus, Lateral with chemical compounds

• The lateral vestibular nucleus units included in these three groups accounted for 29% of those tested for response to extensor muscles and cortical sites controlling extensors and 15% of those tested for response to flexor muscles and cortical sites controlling flexors [15].
• Electromyographic effects of serotonin application into the lateral vestibular nucleus [16].
• Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo [17].
• 1. The olivary projections to the lateral vestibular nucleus (LVN), direct and excitatory through climbing fiber collaterals and indirect and inhibitory through climbing fiber activated Purkinje cells, were investigated in cats with the spinal cord transected at C3 sparing only the contralateral ventral funiculus [18].
• A higher GABAergic tone was found in old rats, as indicated by higher benzodiazepine receptor density in lateral vestibular nucleus and higher mRNA level for glutamic acid decarboxylase in cerebral cortex and medial vestibular nucleus [19].

Gene context of Vestibular Nucleus, Lateral

• Calbindin D-28k in the lateral vestibular nucleus of mutant mice as a tool to reveal Purkinje cell plasticity [20].
• In this study sizes of anti-GAD immunopositive terminals in the dorsal part of the lateral vestibular nucleus (dLVN) of normal mice and Weaver mutants were quantified morphometrically [21].
• Immunocytochemical localization of glutamic acid decarboxylase in the dorsal lateral vestibular nucleus: evidence for an intrinsic and extrinsic GABAergic innervation [22].
• To identify the origin of CaBP-immunopositive (CaBP+) terminals and fibres in the dorsal part of the lateral vestibular nucleus (dLVN), brains of Purkinje cell degeneration mutants (PCD) were immunoreacted for CaBP using the avidin-biotin method (ABC) [20].
• Before onset of neurological symptoms, transketolase (TK) activities were found to be selectively reduced by 25% in lateral vestibular nucleus and surrounding pons [2].

Analytical, diagnostic and therapeutic context of Vestibular Nucleus, Lateral

• Within 150-micron brain stem coronal section micropunches analyzed by high performance liquid chromatography techniques, the polyamine spermidine was significantly increased in the ipsilateral lateral vestibular nucleus 8 hours following labyrinthectomy in the guinea pig model [23].
• Functional studies with iontophoresis of GABA, taurine, and motilin into rabbit lateral vestibular nucleus elicited strong depressant effect on neuronal firing [24].

References