Disease relevance of Oxamisole

• Inhibition of murine hepatitis virus infections by the immunomodulator 2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo[1,2a]pyridine (PR-879-317A) [1].
• PR 879-317A enhances in vitro immune activity of peripheral blood mononuclear cells from patients with Down syndrome [2].
• However, oxamisole did not significantly modify the classical T-cell-mediated delayed hypersensitivity responses to either the protein antigen methylated bovine serum albumin or to the contact-sensitizing antigen oxazolone [3].

High impact information on Oxamisole

• However, cells from mice treated with Oxamisole did not demonstrate altered natural killer cell activity [4].
• On day 4 post-viral exposure, splenic cells from some of the drug- and placebo-treated cells of infected mice injected with Oxamisole, 25 mg/kg/day, produced significantly more interleukin-1 and interleukin-2 than cells of infected mice treated with saline only [4].
• It is concluded that Oxamisole, when administered to mice infected with murine hepatitis virus, has antiviral properties which possibly are mediated through the immunomodulatory effects of this compound on the immune system [4].
• Oxamisole is a T-cell immunorestorative agent when administered by the oral (p.o.) route [3].
• Oxamisole restored cellular immunocompetence, as evidenced by an increase in the in vitro proliferative response of normal murine splenocytes to T-cell mitogens, while decreasing B-cell mitogenic responses [3].

Chemical compound and disease context of Oxamisole

• Peripheral blood mononuclear cells (PBMC) from patients with Down Syndrome were assayed in several in vitro assays following incubation in medium or various concentrations of PR 879-317A (2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxyimidazo (1,2a) pyridine), a selective immunorestorative agent [2].

Biological context of Oxamisole

• Incubation in PR 879-317A significantly increased the NK and ADCC activities of PBMC from both patients and healthy subjects [2].

Anatomical context of Oxamisole

• In addition, the number of patients' cells forming spontaneous rosettes with sheep red blood cells was increased following incubation in PR 879-317A [2].
• When assayed in vitro, oxamisole enhanced macrophage chemotactic function but not phagocytic function, suggesting a potential stimulation of the reticuloendothelial system [3].

Gene context of Oxamisole

• Unlike the response to SRBC, the humoral immunocompetence of both normal and immunosuppressed animals sensitized with the T-independent antigen, trinitrophenyl-lipopolysaccharide (TNP-LPS) was unaffected by oxamisole [3].
• Incubation in PR 879-317A augmented to normal levels the responses of patients' cells in various assessments of T-cell immunity including blastogenic responses to phytohemagglutinin and concanavalin A and production of LIF [2].

References