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Chemical Compound Review

Oxamisol     5,5-dimethoxy-8-phenyl-1,7...

Synonyms: Oxamisole, Oxamisolum, SureCN10376424, AC1L4BTM, 99258-56-7, ...
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Disease relevance of Oxamisole


High impact information on Oxamisole

  • However, cells from mice treated with Oxamisole did not demonstrate altered natural killer cell activity [4].
  • On day 4 post-viral exposure, splenic cells from some of the drug- and placebo-treated cells of infected mice injected with Oxamisole, 25 mg/kg/day, produced significantly more interleukin-1 and interleukin-2 than cells of infected mice treated with saline only [4].
  • It is concluded that Oxamisole, when administered to mice infected with murine hepatitis virus, has antiviral properties which possibly are mediated through the immunomodulatory effects of this compound on the immune system [4].
  • Oxamisole is a T-cell immunorestorative agent when administered by the oral (p.o.) route [3].
  • Oxamisole restored cellular immunocompetence, as evidenced by an increase in the in vitro proliferative response of normal murine splenocytes to T-cell mitogens, while decreasing B-cell mitogenic responses [3].

Chemical compound and disease context of Oxamisole

  • Peripheral blood mononuclear cells (PBMC) from patients with Down Syndrome were assayed in several in vitro assays following incubation in medium or various concentrations of PR 879-317A (2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxyimidazo (1,2a) pyridine), a selective immunorestorative agent [2].

Biological context of Oxamisole

  • Incubation in PR 879-317A significantly increased the NK and ADCC activities of PBMC from both patients and healthy subjects [2].

Anatomical context of Oxamisole


Gene context of Oxamisole

  • Unlike the response to SRBC, the humoral immunocompetence of both normal and immunosuppressed animals sensitized with the T-independent antigen, trinitrophenyl-lipopolysaccharide (TNP-LPS) was unaffected by oxamisole [3].
  • Incubation in PR 879-317A augmented to normal levels the responses of patients' cells in various assessments of T-cell immunity including blastogenic responses to phytohemagglutinin and concanavalin A and production of LIF [2].


  1. Inhibition of murine hepatitis virus infections by the immunomodulator 2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo[1,2a]pyridine (PR-879-317A). Sidwell, R.W., Huffman, J.H., Call, E.W., Warren, R.P., Radov, L.A., Murray, R.J. Antimicrob. Agents Chemother. (1987) [Pubmed]
  2. PR 879-317A enhances in vitro immune activity of peripheral blood mononuclear cells from patients with Down syndrome. Warren, R.P., Healey, M.C., Johnston, A.V., Sidwell, R.W., Radov, L.A., Murray, R.J., Kinsolving, C.R. Int. J. Immunopharmacol. (1987) [Pubmed]
  3. The immunological profile of a new immunomodulatory agent, oxamisole. Radov, L.A., Kamp, D., Trusso, L.A., Sloane, D., Julien, R.P., Clemens, C.M., Murray, R.J. Int. J. Immunopharmacol. (1988) [Pubmed]
  4. Effect of oxamisole on immune parameters of mice infected with murine hepatitis. Warren, R.P., Sidwell, R.W., Huffman, J.H., Call, E.W., Healey, M.C., Johnston, A.V., Radov, L.A., Murray, R.J., Kinsolving, C.R. Int. J. Immunopharmacol. (1990) [Pubmed]
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