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Chemical Compound Review:

AIDA 1-amino-2,3-dihydroindene- 1,5-dicarboxylic...

Synonyms: GNF-PF-1401, CHEMBL313938, SureCN391979, A254_SIGMA, AG-J-13695, ...

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Disease relevance of Indan-1,5-dicarboxylic acid, 1-amino-

We investigated whether the class I metabotropic glutamate receptor (mGluR) antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) is neuroprotective in the KA model of epilepsy [1].
Nevertheless, the metabotropic glutamate receptor (mGluR) group I antagonist 1-aminoindan-1,5-dicarboxylic acid, but also the group I agonist (s)-3,5-dihydroxyphenylglycine (DHPG) exerted protective effects against ALS-CSF toxicity [2].

Psychiatry related information on Indan-1,5-dicarboxylic acid, 1-amino-

Effects of the class I selective metabotropic glutamate receptor antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), on spatial procedural learning and episodic short-term memory of rats were investigated in an appetitively reinforced 3-choice delayed match-to-position task [3].
We here confirm previous reports that systemic application of the Group I antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), causes amnesia in a contextual fear conditioning paradigm in rats [4].

High impact information on Indan-1,5-dicarboxylic acid, 1-amino-

In both cases, the effect could be blocked by addition of the mGluR group I antagonist 1-aminoindan-1,5-dicarboxylic acid [5].
The mGluR antagonists L-2-amino-3-phosphonopropionic acid and 1-aminoindan-1,5-dicarboxylic acid inhibited the LTP facilitatory effect of DHPG but not the transient response depression, whereas alpha-methyl-4-carboxyphenylglycine produced the opposite effects [6].
Likewise, in slices of wild-type mice, preincubation with mGluR1 antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA) or mGluR5 receptor antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocked in both cases completely the increase in frequency following DHPG application [7].
The group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) dose-dependently antagonised PTZ-induced seizures with a mean ED50 value of 465 nmol [8].
The responses to 3,5-DHPG, a highly selective Class I mGluR agonist, were attenuated by (S)-4-carboxyphenylglycine ((S)-4CPG), (+)-alpha-methyl-4-carboxyphenylglycine ((+)-MCPG) and 1-aminoindan-1,5-dicarboxylic acid (UPF-523) with a rank order of potency of (+)-MCPG > or = (S)-4CPG > or = UPF-523 in the different brain regions [9].

Gene context of Indan-1,5-dicarboxylic acid, 1-amino-

Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist [10].
The aim of this study was to examine the role of Group I mGluR subtypes in CTA using a selective mGluR5 antagonist (2-methyl-6-(phenylethynyl)-pyridine, MPEP) and a selective mGluR1 antagonist (1-aminoindan-1,5-dicarboxylic acid, AIDA) [11].

Analytical, diagnostic and therapeutic context of Indan-1,5-dicarboxylic acid, 1-amino-

We show here that intraperitoneal injection of the class I selective antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) in concentrations of 0.18 or 1.8 mg/kg 25 min prior to acquisition training blocks hippocampus-dependent contextual, but not hippocampus-independent cue, conditioning in rats [12].
In the present study we examined the effects of 1-aminoindan-1,5-dicarboxylic acid (AIDA), regarded as a selective and competitive mGluR1 antagonist, in animal models of anxiety [13].
Using immunocytochemistry in conjunction with confocal microscopy, we show that the mGluR5 undergoes agonist- and reflex-evoked internalization that is inhibited by the group I antagonist 1-aminoindan-1,5-dicarboxylic acid [14].

References

AIDA, a class I metabotropic glutamate-receptor antagonist limits kainate-induced hippocampal dysfunction. Renaud, J., Emond, M., Meilleur, S., Psarropoulou, C., Carmant, L. Epilepsia (2002) [Pubmed]
Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro. Anneser, J.M., Chahli, C., Borasio, G.D. Neuroscience (2006) [Pubmed]
The class I metabotropic glutamate receptor antagonist, AIDA, improves short-term and impairs long-term memory in a spatial task for rats. Christoffersen, G.R., Christensen, L.H., Hammer, P., Vang, M. Neuropharmacology (1999) [Pubmed]
Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam. Riedel, G., Sandager-Nielsen, K., Macphail, E.M. Pharmacol. Biochem. Behav. (2002) [Pubmed]
Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis. Anneser, J.M., Chahli, C., Ince, P.G., Borasio, G.D., Shaw, P.J. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
Priming of long-term potentiation induced by activation of metabotropic glutamate receptors coupled to phospholipase C. Cohen, A.S., Raymond, C.R., Abraham, W.C. Hippocampus. (1998) [Pubmed]
Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice. Stoop, R., Conquet, F., Pralong, E. Neuropharmacology (2003) [Pubmed]
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice. Thomsen, C., Dalby, N.O. Neuropharmacology (1998) [Pubmed]
(S)-4-carboxy-3-hydroxyphenylglycine activates phosphatidyl inositol linked metabotropic glutamate receptors in different brain regions of the neonatal rat. Sacaan, A.I., Santori, E.M., Rao, T.S. Neurochem. Int. (1998) [Pubmed]
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. Moroni, F., Lombardi, G., Thomsen, C., Leonardi, P., Attucci, S., Peruginelli, F., Torregrossa, S.A., Pellegrini-Giampietro, D.E., Luneia, R., Pellicciari, R. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. Schachtman, T.R., Bills, C., Ghinescu, R., Murch, K., Serfozo, P., Simonyi, A. Behav. Brain Res. (2003) [Pubmed]
Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Nielsen, K.S., Macphail, E.M., Riedel, G. Eur. J. Pharmacol. (1997) [Pubmed]
The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist. Kłodzińska, A., Tatarczyńska, E., Stachowicz, K., Chojnacka-Wójcik, E. J. Physiol. Pharmacol. (2004) [Pubmed]
Agonist- and reflex-evoked internalization of metabotropic glutamate receptor 5 in enteric neurons. Liu, M., Kirchgessner, A.L. J. Neurosci. (2000) [Pubmed]

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