The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

alpha-Mcpg     4-(1-amino-1-carboxy- ethyl)benzoic acid

Synonyms: CHEMBL299683, SureCN715285, AG-J-02329, ACMC-20cchr, M4796_SIGMA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of alpha-Methyl-cpgly


High impact information on alpha-Methyl-cpgly


Biological context of alpha-Methyl-cpgly


Anatomical context of alpha-Methyl-cpgly


Associations of alpha-Methyl-cpgly with other chemical compounds


Gene context of alpha-Methyl-cpgly


Analytical, diagnostic and therapeutic context of alpha-Methyl-cpgly

  • However, microinjection of 2-amino-5-phosphonopentanoic acid (0.1 and 1 nmol, n = 8), an NMDA- receptor antagonist, or alpha-methyl-4-carboxyphenylglycine (0.1 and 1 nmol, n = 5), a glutamate metabotropic receptor antagonist, failed to attenuate significantly the pressor and RSNA responses to stimulation of cardiac receptors with BK [16].


  1. Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex. Antunes, V.R., Machado, B.H. Autonomic neuroscience : basic & clinical. (2003) [Pubmed]
  2. (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors. Thomsen, C., Bruno, V., Nicoletti, F., Marinozzi, M., Pellicciari, R. Mol. Pharmacol. (1996) [Pubmed]
  3. Dynamics of excitatory synaptic components in sustained firing at low rates. Wyart, C., Cocco, S., Bourdieu, L., Léger, J.F., Herr, C., Chatenay, D. J. Neurophysiol. (2005) [Pubmed]
  4. Characterization of an intracellular alkaline shift in rat astrocytes triggered by metabotropic glutamate receptors. Amos, B.J., Chesler, M. J. Neurophysiol. (1998) [Pubmed]
  5. Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons. Montoliu, C., Llansola, M., Cucarella, C., Grisolía, S., Felipo, V. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  6. Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist. Cozzi, A., Attucci, S., Peruginelli, F., Marinozzi, M., Luneia, R., Pellicciari, R., Moroni, F. Eur. J. Neurosci. (1997) [Pubmed]
  7. Attenuation of morphine withdrawal symptoms by subtype-selective metabotropic glutamate receptor antagonists. Fundytus, M.E., Ritchie, J., Coderre, T.J. Br. J. Pharmacol. (1997) [Pubmed]
  8. Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats. Haibara, A.S., Bonagamba, L.G., Machado, B.H. Am. J. Physiol. (1999) [Pubmed]
  9. Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes. Sureda, F., Copani, A., Bruno, V., Knöpfel, T., Meltzger, G., Nicoletti, F. Eur. J. Pharmacol. (1997) [Pubmed]
  10. The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia. Opitz, T., Richter, P., Reymann, K.G. Neuropharmacology (1994) [Pubmed]
  11. Group I mGlu receptor modulation of dopamine release in the rat striatum in vivo. Bruton, R.K., Ge, J., Barnes, N.M. Eur. J. Pharmacol. (1999) [Pubmed]
  12. Endogenous activation of metabotropic glutamate receptors modulates GABAergic transmission to gonadotropin-releasing hormone neurons and alters their firing rate: a possible local feedback circuit. Chu, Z., Moenter, S.M. J. Neurosci. (2005) [Pubmed]
  13. Metabotropic glutamate receptors depress afferent excitatory transmission in the rat nucleus tractus solitarii. Glaum, S.R., Miller, R.J. J. Neurophysiol. (1993) [Pubmed]
  14. Modulation of epileptiform activity by metabotropic glutamate receptors in immature rat neocortex. Burke, J.P., Hablitz, J.J. J. Neurophysiol. (1995) [Pubmed]
  15. Involvement of NMDA receptor in the regulation of plasma interleukin-6 levels in mice. Song, D.K., Suh, H.W., Jung, J.S., Wie, M.B., Song, J.H., Kim, Y.H. Eur. J. Pharmacol. (1996) [Pubmed]
  16. Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex. Li, D.P., Averill, D.B., Pan, H.L. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
WikiGenes - Universities