Gene Review:
Grm5 - glutamate receptor, metabotropic 5
Mus musculus
Synonyms:
6430542K11Rik, AI850523, Glu5R, Gprc1e, Metabotropic glutamate receptor 5, ...
Casimiro,
Calabresi,
Bernardi,
Jacobsen,
Kos,
Ciruela,
Agopyan,
Popoli,
Belozertseva,
Franco,
Gubellini,
Bespalov,
Lluis,
Olive,
Ferré,
Torvinen,
Bradbury,
Janak,
Desai,
Gruber,
Centonze,
Roder,
Jia,
Vergoni,
Terasmaa,
Brodkin,
Kinder,
McMahon,
Hillion,
Pisani,
Picconi,
Messing,
McGeehan,
Tinner-Staines,
Popik,
Busse,
Conquet,
Bristow,
Vanderklish,
Staines,
Danysz,
Warren,
Agnati,
Varney,
Fuxe,
Rosin,
Bonsi,
Hodge,
Canals,
Lu,
Leo,
- Reduced stress-induced hyperthermia in mGluR5 knockout mice. Brodkin, J., Bradbury, M., Busse, C., Warren, N., Bristow, L.J., Varney, M.A. Eur. J. Neurosci. (2002)
- Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease. Fuxe, K., Agnati, L.F., Jacobsen, K., Hillion, J., Canals, M., Torvinen, M., Tinner-Staines, B., Staines, W., Rosin, D., Terasmaa, A., Popoli, P., Leo, G., Vergoni, V., Lluis, C., Ciruela, F., Franco, R., Ferré, S. Neurology (2003)
- Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Yan, Q.J., Rammal, M., Tranfaglia, M., Bauchwitz, R.P. Neuropharmacology (2005)
- Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Pisani, A., Gubellini, P., Bonsi, P., Conquet, F., Picconi, B., Centonze, D., Bernardi, G., Calabresi, P. Neuroscience (2001)
- Roles of metabotropic glutamate receptors in brain plasticity and pathology. Miller, S., Kesslak, J.P., Romano, C., Cotman, C.W. Ann. N. Y. Acad. Sci. (1995)
- Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Chiamulera, C., Epping-Jordan, M.P., Zocchi, A., Marcon, C., Cottiny, C., Tacconi, S., Corsi, M., Orzi, F., Conquet, F. Nat. Neurosci. (2001)
- Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice. Brody, S.A., Geyer, M.A. Neurotoxicity research. (2004)
- The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Olive, M.F., McGeehan, A.J., Kinder, J.R., McMahon, T., Hodge, C.W., Janak, P.H., Messing, R.O. Mol. Pharmacol. (2005)
- Influence of SIB 1893, a selective mGluR5 receptor antagonist, on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. Borowicz, K.K., Piskorska, B., Łuszczki, J., Czuczwar, S.J. Polish journal of pharmacology. (2003)
- Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Ango, F., Prézeau, L., Muller, T., Tu, J.C., Xiao, B., Worley, P.F., Pin, J.P., Bockaert, J., Fagni, L. Nature (2001)
- PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Hannan, A.J., Blakemore, C., Katsnelson, A., Vitalis, T., Huber, K.M., Bear, M., Roder, J., Kim, D., Shin, H.S., Kind, P.C. Nat. Neurosci. (2001)
- Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Bhave, G., Karim, F., Carlton, S.M., Gereau , R.W. Nat. Neurosci. (2001)
- Neuroprotective effects of MTEP, a selective mGluR5 antagonists and neuropeptide Y on the kainate-induced toxicity in primary neuronal cultures. Domin, H., Kajta, M., Smiałowska, M. Pharmacological reports : PR (2006)
- Early postnatal plasticity in neocortex of FMR1 knockout mice. Desai, N.S., Casimiro, T.M., Gruber, S.M., Vanderklish, P.W. J. Neurophysiol. (2006)
- Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception. Narita, M., Suzuki, M., Narita, M., Niikura, K., Nakamura, A., Miyatake, M., Aoki, T., Yajima, Y., Suzuki, T. J. Neurochem. (2005)
- Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations. Flint, A.C., Dammerman, R.S., Kriegstein, A.R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The PDZ Scaffold NHERF-2 Interacts with mGluR5 and Regulates Receptor Activity. Paquet, M., Asay, M.J., Fam, S.R., Inuzuka, H., Castleberry, A.M., Oller, H., Smith, Y., Yun, C.C., Traynelis, S.F., Hall, R.A. J. Biol. Chem. (2006)
- Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. Lu, Y.M., Jia, Z., Janus, C., Henderson, J.T., Gerlai, R., Wojtowicz, J.M., Roder, J.C. J. Neurosci. (1997)
- Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. Lee, A.C., Wong, R.K., Chuang, S.C., Shin, H.S., Bianchi, R. J. Neurophysiol. (2002)
- Activation of metabotropic glutamate receptors induces propagating network oscillations in the intact cerebral cortex of the newborn mouse. Wagner, J., Luhmann, H.J. Neuropharmacology (2006)
- Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. Karim, F., Wang, C.C., Gereau, R.W. J. Neurosci. (2001)
- The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. Chavis, P., Shinozaki, H., Bockaert, J., Fagni, L. J. Neurosci. (1994)
- Gq protein alpha subunits Galphaq and Galpha11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Tanaka, J., Nakagawa, S., Kushiya, E., Yamasaki, M., Fukaya, M., Iwanaga, T., Simon, M.I., Sakimura, K., Kano, M., Watanabe, M. Eur. J. Neurosci. (2000)
- Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. Bottai, D., Guzowski, J.F., Schwarz, M.K., Kang, S.H., Xiao, B., Lanahan, A., Worley, P.F., Seeburg, P.H. J. Neurosci. (2002)
- An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Saito, H., Kimura, M., Inanobe, A., Ohe, T., Kurachi, Y. Biochem. Biophys. Res. Commun. (2002)
- Physiological role for casein kinase 1 in glutamatergic synaptic transmission. Chergui, K., Svenningsson, P., Greengard, P. J. Neurosci. (2005)
- Gene targeting reveals a role for the glutamate receptors mGluR5 and GluR2 in learning and memory. Jia, Z., Lu, Y.M., Agopyan, N., Roder, J. Physiol. Behav. (2001)
- Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons. Ribeiro, F.M., Ferreira, L.T., Paquet, M., Cregan, T., Ding, Q., Gros, R., Ferguson, S.S. J. Biol. Chem. (2009)
- Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests. Belozertseva, I.V., Kos, T., Popik, P., Danysz, W., Bespalov, A.Y. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2007)
- The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Hodge, C.W., Miles, M.F., Sharko, A.C., Stevenson, R.A., Hillmann, J.R., Lepoutre, V., Besheer, J., Schroeder, J.P. Psychopharmacology (Berl.) (2006)
- Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus. Liu, X.B., Muñoz, A., Jones, E.G. J. Comp. Neurol. (1998)
- Potentiation of mouse vagal afferent mechanosensitivity by ionotropic and metabotropic glutamate receptors. Slattery, J.A., Page, A.J., Dorian, C.L., Brierley, S.M., Blackshaw, L.A. J. Physiol. (Lond.) (2006)