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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL328984     4-(amino-carboxy- methyl)benzoic acid

Synonyms: SureCN2266884, HMDB02016, CHEBI:242989, NSC-644612, CTK2H8632, ...
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High impact information on NCI60_015099


Biological context of NCI60_015099


Anatomical context of NCI60_015099


Associations of NCI60_015099 with other chemical compounds


Gene context of NCI60_015099

  • In fact, the Group III agonist AP-4 had no effect, and the ACPD facilitatory effect was blocked by the Group I mGluR antagonists (S)-4-carboxyphenylglycine (CPG) and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) [12].

Analytical, diagnostic and therapeutic context of NCI60_015099


  1. Group I metabotropic glutamate receptors (mGluRs) modulate visual responses in the superficial superior colliculus of the rat. Cirone, J., Pothecary, C.A., Turner, J.P., Salt, T.E. J. Physiol. (Lond.) (2002) [Pubmed]
  2. Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats. Yashpal, K., Fisher, K., Chabot, J.G., Coderre, T.J. Pain (2001) [Pubmed]
  3. Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors. Schwarzer, C., Sperk, G. Hippocampus. (1998) [Pubmed]
  4. Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons. Yu, S.P., Sensi, S.L., Canzoniero, L.M., Buisson, A., Choi, D.W. J. Physiol. (Lond.) (1997) [Pubmed]
  5. Subtype-specific involvement of metabotropic glutamate receptors in two forms of long-term potentiation in the dentate gyrus of freely moving rats. Manahan-Vaughan, D., Braunewell, K.H., Reymann, K.G. Neuroscience (1998) [Pubmed]
  6. Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells. Toms, N.J., Jane, D.E., Tse, H.W., Roberts, P.J. Br. J. Pharmacol. (1995) [Pubmed]
  7. Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn. Zhong, J., Gerber, G., Kojić, L., Randić, M. Brain Res. (2000) [Pubmed]
  8. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Fisher, K., Coderre, T.J. Pain (1996) [Pubmed]
  9. Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Doherty, A.J., Collingridge, G.L., Jane, D.E. Br. J. Pharmacol. (1999) [Pubmed]
  10. Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Brabet, I., Mary, S., Bockaert, J., Pin, J.P. Neuropharmacology (1995) [Pubmed]
  11. Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons. Ugolini, A., Corsi, M., Bordi, F. Neuropharmacology (1997) [Pubmed]
  12. The metabotropic glutamate receptors of the vestibular organs. Guth, P.S., Holt, J.C., Perin, P., Athas, G., Garcia, M., Puri, A., Zucca, G., Botta, L., Valli, P. Hear. Res. (1998) [Pubmed]
  13. Modulation of seizure activity in mice by metabotropic glutamate receptor ligands. Dalby, N.O., Thomsen, C. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
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