Disease relevance of CCRIS 5094

• Metabolism of ochratoxin B and its possible effects upon the metabolism and toxicity of ochratoxin A in rats [1].
• Influence of ochratoxin B on the ochratoxin A inhibition of phenylalanyl-tRNA formation in vitro and protein synthesis in hepatoma tissue culture cells [2].

High impact information on CCRIS 5094

• DNA-strand breaks were evident in liver, kidney, and spleen of animals treated with OTA, and a similar degree of DNA damage was observed in rats treated with OTB, despite the lower toxicity of OTB [3].
• The systemic availability of OA and its dechloro-analog, Ochratoxin B (OB), calculated as the area under the curve (AUC) was reduced to 75 and 68%, respectively, of the control group (P < 0.05) [4].
• The Km for the formation of 4-hydroxyochratoxin B was determined, and the hydroxylation of ochratoxin A was not altered by the presence of ochratoxin B [1].
• Biotransformation and nephrotoxicity of ochratoxin B in rats [5].
• Three quantitative approaches, standard addition method, internal standard method (using ochratoxin B as an internal standard) and external standard method, were compared in the analysis of human blood plasma [6].

Biological context of CCRIS 5094

• A similar but smaller investigation on the toxicokinetics and binding properties of ochratoxin B was also performed [7].

Associations of CCRIS 5094 with other chemical compounds

• Monoclonal antibodies against ochratoxin B (OTB) were generated by immunizing Balb/c mice with OTB conjugated to keyhole limpet hemocyanin (KLH) via carbodiimide reactions with CHMC and EDAC [8].
• When applying confirmatory tests neither aflatoxins B1, B2, G1, G2 nor sterigmatocystin, zearalenone, or ochratoxin B were found to be present in any of the samples of barley, wheat, rye, or oats [9].

Analytical, diagnostic and therapeutic context of CCRIS 5094

• The distribution patterns of ochratoxin A and its nontoxic dechloro-analogue ochratoxin B were studied in rats using whole-body autoradiography [10].

References