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Chemical Compound Review

OCHRATOXIN B     (2S)-2-[[(3R)-8-hydroxy-3- methyl-1-oxo...

Synonyms: SureCN455061, CCRIS 5094, HSDB 3438, AC1L2HCL, LS-16139, ...
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Disease relevance of CCRIS 5094


High impact information on CCRIS 5094

  • DNA-strand breaks were evident in liver, kidney, and spleen of animals treated with OTA, and a similar degree of DNA damage was observed in rats treated with OTB, despite the lower toxicity of OTB [3].
  • The systemic availability of OA and its dechloro-analog, Ochratoxin B (OB), calculated as the area under the curve (AUC) was reduced to 75 and 68%, respectively, of the control group (P < 0.05) [4].
  • The Km for the formation of 4-hydroxyochratoxin B was determined, and the hydroxylation of ochratoxin A was not altered by the presence of ochratoxin B [1].
  • Biotransformation and nephrotoxicity of ochratoxin B in rats [5].
  • Three quantitative approaches, standard addition method, internal standard method (using ochratoxin B as an internal standard) and external standard method, were compared in the analysis of human blood plasma [6].

Biological context of CCRIS 5094


Associations of CCRIS 5094 with other chemical compounds

  • Monoclonal antibodies against ochratoxin B (OTB) were generated by immunizing Balb/c mice with OTB conjugated to keyhole limpet hemocyanin (KLH) via carbodiimide reactions with CHMC and EDAC [8].
  • When applying confirmatory tests neither aflatoxins B1, B2, G1, G2 nor sterigmatocystin, zearalenone, or ochratoxin B were found to be present in any of the samples of barley, wheat, rye, or oats [9].

Analytical, diagnostic and therapeutic context of CCRIS 5094


  1. Metabolism of ochratoxin B and its possible effects upon the metabolism and toxicity of ochratoxin A in rats. Størmer, F.C., Kolsaker, P., Holm, H., Rogstad, S., Elling, F. Appl. Environ. Microbiol. (1985) [Pubmed]
  2. Influence of ochratoxin B on the ochratoxin A inhibition of phenylalanyl-tRNA formation in vitro and protein synthesis in hepatoma tissue culture cells. Roth, A., Creppy, E.E., Kane, A., Bacha, H., Steyn, P.S., Röschenthaler, R., Dirheimer, G. Toxicol. Lett. (1989) [Pubmed]
  3. Ochratoxin a causes DNA damage and cytogenetic effects but no DNA adducts in rats. Mally, A., Pepe, G., Ravoori, S., Fiore, M., Gupta, R.C., Dekant, W., Mosesso, P. Chem. Res. Toxicol. (2005) [Pubmed]
  4. Alkalinization of urinary pH accelerates renal excretion of ochratoxin A in pigs. Blank, R., Wolffram, S. J. Nutr. (2004) [Pubmed]
  5. Biotransformation and nephrotoxicity of ochratoxin B in rats. Mally, A., Keim-Heusler, H., Amberg, A., Kurz, M., Zepnik, H., Mantle, P., Völkel, W., Hard, G.C., Dekant, W. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  6. Quantitative determination of ochratoxin A by liquid chromatography/electrospray tandem mass spectrometry. Lau, B.P., Scott, P.M., Lewis, D.A., Kanhere, S.R. Journal of mass spectrometry : JMS. (2000) [Pubmed]
  7. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. Hagelberg, S., Hult, K., Fuchs, R. Journal of applied toxicology : JAT. (1989) [Pubmed]
  8. Production and characterization of monoclonal antibodies against ochratoxin B. Heussner, A.H., Moeller, I., Day, B.W., Dietrich, D.R., O'brien, E. Food Chem. Toxicol. (2007) [Pubmed]
  9. Occurrence of mycotoxins in animal feeds. Juszkiewicz, T., Piskorska-Pliszczyńska, J. J. Environ. Pathol. Toxicol. Oncol. (1992) [Pubmed]
  10. Distribution of 14C-ochratoxin A and 14C-ochratoxin B in rats: a comparison based on whole-body autoradiography. Breitholtz Emanuelsson, A., Fuchs, R., Hult, K., Appelgren, L.E. IARC Sci. Publ. (1991) [Pubmed]
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