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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Monthyle     2-hydroxyethyl octadecanoate

Synonyms: Lactine, Polystate, Sedetol, Ivorit, Monthybase, ...
 
 
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Disease relevance of Ethylene glycol monostearate SE

 

High impact information on Ethylene glycol monostearate SE

  • Cremophor EL (cremophor), a component of the paclitaxel formulation, can potentially reverse P-glycoprotein-associated multidrug resistance [2].
  • Oral test G-CSF solution was prepared with 10% HCO-60 (polyoxyethylated, 60 mumol, castor oil derivative), 1% DK ester (sugar ester) or 10% MYS-40 (polyethyleneglycol monostearate), in which the G-CSF concentration was 500 or 250 micrograms/ml [3].
  • Formulations of the same composition, but prepared using Myrj 53 and tween 20 as emulsifiers, showed a larger particle size than formulations prepared using tween 80 and Brij 35 [4].
  • In the standard-Gd and high-Gd formulations used, the weight ratios of soybean oil, water, Gd-DTPA derivative (Gd-DTPA-SA or Gd-DTPA-SE), hydrogenated L-alpha-phosphatidylcholine from egg yolk (HEPC) and co-surfactant (HCO-60, Myrj 53, Myrj 59 or Brij 700) were 7.36:92:1:2:3 and 7.36:92:2:1:3, respectively [5].
  • We investigated the pharmacokinetics of intramuscular cyclosporine administration in the baboon using three carriers: polyoxethylated castor oil (Cremophor), a mixture of octanoic and decanoic acids (Miglyol), and olive oil [6].
 

Biological context of Ethylene glycol monostearate SE

  • On the other hand, Myrj 59 did not decrease the acute in-vivo toxicity of the drug (LD50 and nephrotoxicity) [1].
 

Gene context of Ethylene glycol monostearate SE

  • The esters with shorter aliphatic chains had negligible effects, whereas those with longer chains, PEG-palmitate (P-PEG; C16) and PEG-stearate (S-PEG; C18) reduced the locomotion, irrespectively of concentration [7].
 

Analytical, diagnostic and therapeutic context of Ethylene glycol monostearate SE

References

  1. The influence of Myrj 59 on the solubility, toxicity and activity of amphotericin B. Tasset, C., Préat, V., Roland, M. J. Pharm. Pharmacol. (1991) [Pubmed]
  2. Phase I trial of cremophor EL with bolus doxorubicin. Millward, M.J., Webster, L.K., Rischin, D., Stokes, K.H., Toner, G.C., Bishop, J.F., Olver, I.N., Linahan, B.M., Linsenmeyer, M.E., Woodcock, D.M. Clin. Cancer Res. (1998) [Pubmed]
  3. Is recombinant human granulocyte colony-stimulating factor (G-CSF) orally available in rats? Takada, K., Tohyama, Y., Oohashi, M., Yoshikawa, H., Muranishi, S., Shimosaka, A., Kaneko, T. Chem. Pharm. Bull. (1989) [Pubmed]
  4. Relationship between internal phase volume and emulsion stability: the cetyl alcohol/stearyl alcohol system. Sepulveda, E., Kildsig, D.O., Ghaly, E.S. Pharmaceutical development and technology. (2003) [Pubmed]
  5. Biodistribution of gadolinium incorporated in lipid emulsions intraperitoneally administered for neutron-capture therapy with tumor-bearing hamsters. Miyamoto, M., Hirano, K., Ichikawa, H., Fukumori, Y., Akine, Y., Tokuuye, K. Biol. Pharm. Bull. (1999) [Pubmed]
  6. Role of the carrier solution in cyclosporine pharmacokinetics in the baboon. Kurlansky, P.A., Sadeghi, A.M., Michler, R.E., Coppey, L.J., Re, L.P., Thomas, W.G., Smith, C.R., Reemtsma, K., Rose, E.A. The Journal of heart transplantation. (1986) [Pubmed]
  7. Modulation of polymorphonuclear leukocyte locomotion by synthetic amphiphiles: effect of saturated fatty acid esters (C2-C18) of poly(ethyleneglycol) 6000. Dahlgren, C., Rundqvist, I., Stendahl, O., Magnusson, K.E. Cell Biophys. (1980) [Pubmed]
  8. Charge-transfer chromatographic study on the interaction of amino acids with ethoxylated stearic acid surfactants. Cserháti, T. Biomed. Chromatogr. (1994) [Pubmed]
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