Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

SureCN358425 (3-phenoxyphenyl)methanol

Synonyms: AG-D-77474, ACMC-209chh, CHEBI:62527, ANW-20451, CPD-13113, ...

Anadón, A. et al., Qin, S. et al., Heder, A.F. et al., Mortimer, R.D. et al., Bast, G.E. et al.

Heder, Hirsch-Ernst, Bauer, Kahl, Desel,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on BRN 0475312

Several metabolites of permethrin formed by hepatocytes (3-(2',2'-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid, 3-phenoxybenzyl alcohol, and 3-phenoxybenzoic acid) were ineffective in inducing CYP2B1 mRNA [1].
Plasma, hypothalamus, cerebellum, frontal cortex, caudate putamen, hippocampus, medulla oblongata, sciatic nerve, and liver concentrations of permethrin and its metabolites, m-phenoxybenzyl alcohol and m-phenoxybenzoic acid, were determined by a high-performance liquid chromatographic assay [2].
The direct hydrolysis products, cyclopropanic acid (Cl2CA), 3-phenoxybenzyl alcohol (PBalc), and 3-phenoxybenzoic acid (PBacid), were recovered at small percentages, ranging from 1 to 14% for Cl2CA and from 0.2 to 6% for PBalc and PBacid [3].
The KI of 4-methylpyrazole for alcohol dehydrogenase from horse liver was 0.6 (3-phenoxybenzyl alcohol) vs. 0.04 microM (ethanol) [4].

Analytical, diagnostic and therapeutic context of BRN 0475312

Determination of total free and glucose-conjugated 3-phenoxybenzyl alcohol residues in foods by gas chromatography with electron capture detection [5].

References

Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures. Heder, A.F., Hirsch-Ernst, K.I., Bauer, D., Kahl, G.F., Desel, H. Biochem. Pharmacol. (2001) [Pubmed]
Toxicokinetics of permethrin in the rat. Anadón, A., Martinez-Larrañaga, M.R., Diaz, M.J., Bringas, P. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
Enantiomeric differences in permethrin degradation pathways in soil and sediment. Qin, S., Gan, J. J. Agric. Food Chem. (2006) [Pubmed]
Dehydrogenation of 3-phenoxybenzyl alcohol in isolated perfused rabbit skin, skin homogenate and purified dehydrogenases. Bast, G.E., Kampffmeyer, H.G. Skin Pharmacol. Appl. Skin Physiol. (1998) [Pubmed]
Determination of total free and glucose-conjugated 3-phenoxybenzyl alcohol residues in foods by gas chromatography with electron capture detection. Mortimer, R.D., Shields, J.B. Journal of AOAC International. (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share