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Gene Review

Cyp2b1  -  cytochrome P450, family 2, subfamily b,...

Rattus norvegicus

Synonyms: CYPIIB1, Cyp2b-1, Cypbe, Cytochrome P450 2B1, Cytochrome P450-B, ...
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Disease relevance of Cyp2b1


High impact information on Cyp2b1


Biological context of Cyp2b1


Anatomical context of Cyp2b1


Associations of Cyp2b1 with chemical compounds


Regulatory relationships of Cyp2b1


Other interactions of Cyp2b1


Analytical, diagnostic and therapeutic context of Cyp2b1


  1. Cytochrome P450 2B1 mediates oxidant injury in puromycin-induced nephrotic syndrome. Liu, H., Bigler, S.A., Henegar, J.R., Baliga, R. Kidney Int. (2002) [Pubmed]
  2. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Aghi, M., Chou, T.C., Suling, K., Breakefield, X.O., Chiocca, E.A. Cancer Res. (1999) [Pubmed]
  3. A barbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria. He, J.S., Fulco, A.J. J. Biol. Chem. (1991) [Pubmed]
  4. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Wei, M.X., Tamiya, T., Chase, M., Boviatsis, E.J., Chang, T.K., Kowall, N.W., Hochberg, F.H., Waxman, D.J., Breakefield, X.O., Chiocca, E.A. Hum. Gene Ther. (1994) [Pubmed]
  5. Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide. Manome, Y., Wen, P.Y., Chen, L., Tanaka, T., Dong, Y., Yamazoe, M., Hirshowitz, A., Kufe, D.W., Fine, H.A. Gene Ther. (1996) [Pubmed]
  6. Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Michalopoulos, G.K., Bowen, W.C., Zajac, V.F., Beer-Stolz, D., Watkins, S., Kostrubsky, V., Strom, S.C. Hepatology (1999) [Pubmed]
  7. Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver. Nuwaysir, E.F., Dragan, Y.P., Jefcoate, C.R., Jordan, V.C., Pitot, H.C. Cancer Res. (1995) [Pubmed]
  8. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. Kumar, S., Chen, C.S., Waxman, D.J., Halpert, J.R. J. Biol. Chem. (2005) [Pubmed]
  9. Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1. Alterman, M.A., Hanzlik, R.P. FEBS Lett. (2002) [Pubmed]
  10. Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures. Heder, A.F., Hirsch-Ernst, K.I., Bauer, D., Kahl, G.F., Desel, H. Biochem. Pharmacol. (2001) [Pubmed]
  11. Induction of hepatic cytochrome P-450 by phenobarbital in semi-aquatic frog (Rana pipiens). Khan, M.A., Qadri, S.Y., Tomar, S., Fish, D., Gururajan, L., Poria, M.S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  12. Effects of motorcycle exhaust inhalation exposure on cytochrome P-450 2B1, antioxidant enzymes, and lipid peroxidation in rat liver and lung. Ueng, T.H., Wang, H.W., Hung, C.C., Chang, H.L. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
  13. Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-,N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine. Shu, L., Hollenberg, P.F. Carcinogenesis (1996) [Pubmed]
  14. Induction of cytochrome P-450 isozymes by chromanamine derivatives in rat liver. Tsukidate, K., Sagami, F., Horie, T., Fukuda, T., Kitada, M., Kanakubo, Y. Xenobiotica (1989) [Pubmed]
  15. Expression of cytochrome P450b and P450e genes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides. Traber, P.G., Chianale, J., Florence, R., Kim, K., Wojcik, E., Gumucio, J.J. J. Biol. Chem. (1988) [Pubmed]
  16. Ethanol interferes with regeneration-associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity? Diehl, A.M., Bisgaard, H.C., Kren, B.T., Steer, C.J. Hepatology (1991) [Pubmed]
  17. Inductive effect of Telazol on hepatic expression of cytochrome P450 2B in rats. Wong, A., Bandiera, S.M. Biochem. Pharmacol. (1996) [Pubmed]
  18. Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1. Muangmoonchai, R., Smirlis, D., Wong, S.C., Edwards, M., Phillips, I.R., Shephard, E.A. Biochem. J. (2001) [Pubmed]
  19. Ethylbenzene-mediated induction of cytochrome P450 isozymes in male and female rats. Sequeira, D.J., Eyer, C.S., Cawley, G.F., Nick, T.G., Backes, W.L. Biochem. Pharmacol. (1992) [Pubmed]
  20. Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes. Joannard, F., Rissel, M., Gilot, D., Anderson, A., Orfila-Lefeuvre, L., Guillouzo, A., Atfi, A., Lagadic-Gossmann, D. Toxicol. Lett. (2006) [Pubmed]
  21. Involvement of heme in the transcriptional activation of CYPIIB1/B2 gene by phenobarbitone in rat liver--studies with succinylacetone. Venkateswar, V., Padmanaban, G. Arch. Biochem. Biophys. (1991) [Pubmed]
  22. Selective expression and induction of cytochrome P450PB and P450MC during the development of hereditary hepatitis and hepatoma of LEC rats. Sugiyama, T., Suzuki, K., Ookawara, T., Kurosawa, T., Taniguchi, N. Carcinogenesis (1989) [Pubmed]
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