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Chemical Compound Review

Elimite     (3-phenoxyphenyl)methyl 3-(2,2...

Synonyms: PerFoam, Ambush, Permethrin, Pounce, CHEMBL1525, ...
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Disease relevance of Permethrin

  • Community control of scabies: a model based on use of permethrin cream [1].
  • We propose that an equivalent shift of the sodium current activation curve in kdr insects could account for their low sensitivity to permethrin toxicity [2].
  • Single application of Nix (permethrin 1% creme rinse) and Rid were compared as treatments for Pediculosis capitis in 435 patients, the majority of whom were children [3].
  • Impregnation of clothing with permethrin is suggested for nonimmune populations who are likely to be exposed to malaria or leishmaniasis over a period of 1-2 months [4].
  • Is permethrin 5% cream effective for rosacea [5]?

Psychiatry related information on Permethrin


High impact information on Permethrin


Chemical compound and disease context of Permethrin


Biological context of Permethrin

  • Thirty-seven local public health departments enrolled a total of 38,160 patients for 47,578 treatments with permethrin or other pediculicides from September 1, 1986, through January 31, 1988 [19].
  • Thus, permethrin-stimulated gene expression occurred on the transcriptional level [12].
  • Furthermore, permethrin stimulated the expression of the luciferase reporter gene under control of the CYP2B1 promoter (comprising the PB-responsive enhancer module) in transiently transfected primary hepatocyte cultures [12].
  • Effects of permethrin-treated bed nets on immunity to malaria in western Kenya II. Antibody responses in young children in an area of intense malaria transmission [20].
  • The first QTL, rtp1, colocalizes with the sodium channel gene on chromosome 2L thus further supporting the importance of mutations in this gene in conferring permethrin resistance [21].

Anatomical context of Permethrin


Associations of Permethrin with other chemical compounds

  • The effects of DDT and permethrin on inhibition of reconstituted Ca-ATPase were higher when the insecticide was first added to the protein portion and the enzyme was then reconstituted with the phospholipids, than when the same amount of insecticide was first added to the phospholipids which were then used for reconstitution [26].
  • Neither permethrin nor d-trans allethrin affected pS2 expression [27].
  • Evidence for double resistance to permethrin and malathion in head lice [28].
  • Effectiveness of residual spraying of peridomestic ecotopes with deltamethrin and permethrin on Triatoma infestans in rural western Argentina: a district-wide randomized trial [29].
  • In vivo blood and brain levels of the scabicides were measured in guinea pigs following three daily applications of 5% permethrin cream or 1% lindane lotion [30].

Gene context of Permethrin


Analytical, diagnostic and therapeutic context of Permethrin


  1. Community control of scabies: a model based on use of permethrin cream. Taplin, D., Porcelain, S.L., Meinking, T.L., Athey, R.L., Chen, J.A., Castillero, P.M., Sanchez, R. Lancet (1991) [Pubmed]
  2. Functional analysis of a rat sodium channel carrying a mutation for insect knock-down resistance (kdr) to pyrethroids. Vais, H., Williamson, M.S., Hick, C.A., Eldursi, N., Devonshire, A.L., Usherwood, P.N. FEBS Lett. (1997) [Pubmed]
  3. Eradication of head lice with a single treatment. DiNapoli, J.B., Austin, R.D., Englender, S.J., Gomez, M.P., Barrett, J.F. American journal of public health. (1988) [Pubmed]
  4. Efficacy of permethrin-impregnated uniforms in the prevention of malaria and leishmaniasis in Colombian soldiers. Soto, J., Medina, F., Dember, N., Berman, J. Clin. Infect. Dis. (1995) [Pubmed]
  5. Is permethrin 5% cream effective for rosacea? Swenor, M.E. The Journal of family practice. (2003) [Pubmed]
  6. Atypical presentation of scabies among nursing home residents. Wilson, M.M., Philpott, C.D., Breer, W.A. J. Gerontol. A Biol. Sci. Med. Sci. (2001) [Pubmed]
  7. Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids. Nasuti, C., Gabbianelli, R., Falcioni, M.L., Di Stefano, A., Sozio, P., Cantalamessa, F. Toxicology (2007) [Pubmed]
  8. Effectiveness of permethrin-treated military uniform fabric against human body lice. Sholdt, L.L., Rogers, E.J., Gerberg, E.J., Schreck, C.E. Military medicine. (1989) [Pubmed]
  9. Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: repression by epidermal growth factor is mediated via a distal enhancer region. Bauer, D., Wolfram, N., Kahl, G.F., Hirsch-Ernst, K.I. Mol. Pharmacol. (2004) [Pubmed]
  10. Capillary electrophoresis of pesticides: V. Analysis of pyrethroid insecticides via their hydrolysis products labeled with a fluorescing and UV absorbing tag for laser-induced fluorescence and UV detection. Karcher, A., El Rassi, Z. Electrophoresis (1997) [Pubmed]
  11. An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice. Meinking, T.L., Clineschmidt, C.M., Chen, C., Kolber, M.A., Tipping, R.W., Furtek, C.I., Villar, M.E., Guzzo, C.A. J. Pediatr. (2002) [Pubmed]
  12. Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures. Heder, A.F., Hirsch-Ernst, K.I., Bauer, D., Kahl, G.F., Desel, H. Biochem. Pharmacol. (2001) [Pubmed]
  13. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and Purkinje neuron loss in the cerebellum. Abdel-Rahman, A., Shetty, A.K., Abou-Donia, M.B. Exp. Neurol. (2001) [Pubmed]
  14. Pharmacotherapy of ectoparasitic infections. Roos, T.C., Alam, M., Roos, S., Merk, H.F., Bickers, D.R. Drugs (2001) [Pubmed]
  15. The influence of diethyl-m-toluamide (DEET) on the percutaneous absorption of permethrin and carbaryl. Baynes, R.E., Halling, K.B., Riviere, J.E. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  16. Solid-phase sediment toxicity identification evaluation in an agricultural stream. Phillips, B.M., Anderson, B.S., Hunt, J.W., Huntley, S.A., Tjeerdema, R.S., Kapellas, N., Worcester, K. Environ. Toxicol. Chem. (2006) [Pubmed]
  17. Mutagenic activity in synthetic pyrethroids in Salmonella typhimurium. Herrera, A., Laborda, E. Mutagenesis (1988) [Pubmed]
  18. Pyrethroid insecticides, fenvalerate and permethrin, inhibit progesterone-induced alkaline phosphatase activity in T47D human breast cancer cells. Kim, I.Y., Han, S.Y., Kang, T.S., Lee, B.M., Choi, K.S., Moon, H.J., Kim, T.S., Kang, I.H., Kwack, S.J., Moon, A., Ahn, M.Y., Kim, H.S. J. Toxicol. Environ. Health Part A (2005) [Pubmed]
  19. Postmarketing surveillance study of permethrin creme rinse. Andrews, E.B., Joseph, M.C., Magenheim, M.J., Tilson, H.H., Doi, P.A., Schultz, M.W. American journal of public health. (1992) [Pubmed]
  20. Effects of permethrin-treated bed nets on immunity to malaria in western Kenya II. Antibody responses in young children in an area of intense malaria transmission. Kariuki, S.K., Lal, A.A., Terlouw, D.J., ter Kuile, F.O., Ong'echa, J.M., Phillips-Howard, P.A., Orago, A.S., Kolczak, M.S., Hawley, W.A., Nahlen, B.L., Shi, Y.P. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
  21. Genetic mapping of genes conferring permethrin resistance in the malaria vector, Anopheles gambiae. Ranson, H., Paton, M.G., Jensen, B., McCarroll, L., Vaughan, A., Hogan, J.R., Hemingway, J., Collins, F.H. Insect Mol. Biol. (2004) [Pubmed]
  22. Effect of permethrin on the induction of sister chromatid exchanges and micronuclei in cultured human lymphocytes. Herrera, A., Barrueco, C., Caballo, C., de la Peña, E. Environ. Mol. Mutagen. (1992) [Pubmed]
  23. Toxicokinetics of permethrin in the rat. Anadón, A., Martinez-Larrañaga, M.R., Diaz, M.J., Bringas, P. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  24. Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel. Zhao, Y., Park, Y., Adams, M.E. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  25. Effects of the pyrethroid insecticide permethrin on membrane fluidity. Moya-Quiles, M.R., Munoz-Delgado, E., Vidal, C.J. Chem. Phys. Lipids (1996) [Pubmed]
  26. Role of phospholipids in the inhibitory action of DDT and permethrin on the nerve ATPase of lobster, Homarus americanus. Ghiasuddin, S.M., Kawauchi, S., Matsumura, F., Doherty, J.D. Biochem. Pharmacol. (1982) [Pubmed]
  27. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Go, V., Garey, J., Wolff, M.S., Pogo, B.G. Environ. Health Perspect. (1999) [Pubmed]
  28. Evidence for double resistance to permethrin and malathion in head lice. Dawes, M. Br. J. Dermatol. (2000) [Pubmed]
  29. Effectiveness of residual spraying of peridomestic ecotopes with deltamethrin and permethrin on Triatoma infestans in rural western Argentina: a district-wide randomized trial. Gürtler, R.E., Canale, D.M., Spillmann, C., Stariolo, R., Salomón, O.D., Blanco, S., Segura, E.L. Bull. World Health Organ. (2004) [Pubmed]
  30. Comparative percutaneous absorption of lindane and permethrin. Franz, T.J., Lehman, P.A., Franz, S.F., Guin, J.D. Archives of dermatology. (1996) [Pubmed]
  31. Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays. Kunimatsu, T., Yamada, T., Ose, K., Sunami, O., Kamita, Y., Okuno, Y., Seki, T., Nakatsuka, I. Regulatory toxicology and pharmacology : RTP. (2002) [Pubmed]
  32. Molecular mechanisms of cis-urocanic acid and permethrin-induced alterations in cutaneous immunity. Prater, M.R., Blaylock, B.L., Holladay, S.D. Photodermatology, photoimmunology & photomedicine. (2003) [Pubmed]
  33. Estrogenicity of organophosphorus and pyrethroid pesticides. Chen, H., Xiao, J., Hu, G., Zhou, J., Xiao, H., Wang, X. J. Toxicol. Environ. Health Part A (2002) [Pubmed]
  34. Immunohistochemical changes in the mouse striatum induced by the pyrethroid insecticide permethrin. Pittman, J.T., Dodd, C.A., Klein, B.G. International journal of toxicology. (2003) [Pubmed]
  35. Cytochrome P450 CYP6X1 cDNAs and mRNA expression levels in three strains of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae) having different susceptibilities to pyrethroid insecticide. Zhu, Y.C., Snodgrass, G.L. Insect Mol. Biol. (2003) [Pubmed]
  36. Repression of activity-dependent c-fos and brain-derived neurotrophic factor mRNA expression by pyrethroid insecticides accompanying a decrease in Ca(2+) influx into neurons. Imamura, L., Hasegawa, H., Kurashina, K., Hamanishi, A., Tabuchi, A., Tsuda, M. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  37. Differential permethrin susceptibility of head lice sampled in the United States and Borneo. Pollack, R.J., Kiszewski, A., Armstrong, P., Hahn, C., Wolfe, N., Rahman, H.A., Laserson, K., Telford, S.R., Spielman, A. Archives of pediatrics & adolescent medicine. (1999) [Pubmed]
  38. Inheritance of larval resistance to permethrin in Aedes aegypti and association with sex ratio distortion and life history variation. Mebrahtu, Y.B., Norem, J., Taylor, M. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
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