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Chemical Compound Review

CHEMBL447065     2-bromoprop-2-enal

Synonyms: CCRIS 1618, AG-D-95304, ACMC-20ao1z, LS-14611, CTK4C6108, ...
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Disease relevance of CCRIS 1618


High impact information on CCRIS 1618


Chemical compound and disease context of CCRIS 1618


Anatomical context of CCRIS 1618


  1. Lack of mammalian mutagenicity of the potent bacterial mutagen tris(2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein. van Beerendonk, G.J., Klein, J.C., Tijdens, R.B., Lichtenauer-Kaligis, E.G., Tasseron-de Jong, J.G., Meerman, J.H. Mutat. Res. (1998) [Pubmed]
  2. Formation of cyclic 1,N2-propanodeoxyguanosine and thymidine adducts in the reaction of the mutagen 2-bromoacrolein with calf thymus DNA. Meerman, J.H., Smith, T.R., Pearson, P.G., Meier, G.P., Nelson, S.D. Cancer Res. (1989) [Pubmed]
  3. Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution. van Beerendonk, G.J., Nivard, M.J., Vogel, E.W., Nelson, S.D., Meerman, J.H. Carcinogenesis (1994) [Pubmed]
  4. Identification of N-acetylcysteine conjugates of 1,2-dibromo-3-chloropropane: evidence for cytochrome P450 and glutathione mediated bioactivation pathways. Weber, G.L., Steenwyk, R.C., Nelson, S.D., Pearson, P.G. Chem. Res. Toxicol. (1995) [Pubmed]
  5. Characterization of 2'-deoxycytidine and 2'-deoxyuridine adducts formed in reactions with acrolein and 2-bromoacrolein. Chenna, A., Iden, C.R. Chem. Res. Toxicol. (1993) [Pubmed]
  6. Genotoxicity of 2-halosubstituted enals and 2-chloroacrylonitrile in the Ames test and the SOS-chromotest. Eder, E., Deininger, C., Deininger, D., Weinfurtner, E. Mutat. Res. (1994) [Pubmed]
  7. Activation mechanism of tris(2,3-dibromopropyl)phosphate to the potent mutagen, 2-bromoacrolein. Nelson, S.D., Omichinski, J.G., Iyer, L., Gordon, W.P., Soderlund, E.J., Dybing, E. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
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