Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Evatromonoside 4-[(3S,5R,10S,13R,14S,17S)-3- [(2S,5R)-4,5...

Synonyms: AC1L1GNP, LS-52371, BRN 0066592, 18404-43-8, EINECS 242-284-0, ...

Hazelton, G.A. et al., Ebner, F. et al., von Meyerinck, L. et al., Lacarelle, B. et al.

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High impact information on Digitoxigenin digitoxoside

In guinea-pig myocardium the rates of onset and offset of the inotropic effects of digitoxigenin-monodigitoxoside, digitoxin, ouabain, digoxin, digoxigenin, and dihydroouabain correlated negatively, and independently of the lipophilicity of the steroids, with their intropic and Na-K-ATPase inhibitory potencies [1].
The properties of UDP-glucuronosyltransferase (UDPGT) toward digitoxigenin-monodigitoxoside (DT1) have been studied in human liver microsomes [2].
UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside. Differences in activation and induction properties in rat and mouse liver [3].
When compared to enzyme activity present in native (latent) microsomes of the rat (0.104 +/- 0.010 nmol/min/mg of protein), the activity toward digitoxigenin-monodigitoxoside in mouse native microsomes was 3.5-fold higher (0.379 + 0.44 mumol/min/mg of protein) [3].
Glucuronidation of digitoxigenin-monodigitoxoside was investigated in liver microsomes from spironolactone-induced male Wistar rats [4].

Analytical, diagnostic and therapeutic context of Digitoxigenin digitoxoside

The digitoxigenin-monodigitoxoside UDP-glucuronosyltransferase was further purified using UDP-hexanolamine Sepharose 4B affinity chromatography [4].

References

Diffusion-controlled receptor occupancy determines the rate of inotropic action of some cardioactive steroids. Ebner, F., Bachmaier, A., Schönsteiner, G., Reiter, M. J. Mol. Cell. Cardiol. (1985) [Pubmed]
UDP-glucuronosyltransferase activity toward digitoxigenin monodigitoxoside in human liver microsomes. Lacarelle, B., Rajaonarison, J.F., Catalin, J., Durand, A., Cano, J.P. Drug Metab. Dispos. (1993) [Pubmed]
UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside. Differences in activation and induction properties in rat and mouse liver. Hazelton, G.A., Klaassen, C.D. Drug Metab. Dispos. (1988) [Pubmed]
Separation, purification, and characterization of digitoxigenin-monodigitoxoside UDP-glucuronosyltransferase activity. von Meyerinck, L., Coffman, B.L., Green, M.D., Kirkpatrick, R.B., Schmoldt, A., Tephly, T.R. Drug Metab. Dispos. (1985) [Pubmed]

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