The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Cck-jmv-180     (3S)-3-[[(1S)-2-carboxy-1...

Synonyms: AC1MHYMA, Jmv-180, Jmv 180, 119733-42-5
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Jmv-180


Psychiatry related information on Jmv-180


High impact information on Jmv-180

  • In pancreatic acinar cells cholecystokinin and its analogs, caerulein and CCK-JMV-180, stimulate an increase in intracellular free [Ca2+] by releasing Ca2+ from non-mitochondrial intracellular pools [4].
  • CCK-JMV-180, an analogue of CCK-8-S which has been shown to activate 45Ca2+ efflux in rat cells in a manner similar to CCK-8-S, acted as a potent antagonist of CCK-8-S-induced 45Ca2+ efflux (IC50 = 50 nM) and inhibited [125I]CCK-8-S binding to IMR-32 cells (IC50 = 1.7 nM) [1].
  • CCK-JMV-180 (320 and 1000 micrograms/kg) failed to inhibit emptying when administered alone but dose dependently antagonized CCK induced inhibition of gastric emptying [5].
  • Differential effects of CCK-JMV-180 on food intake in rats and mice [3].
  • We examined the relationships between receptor occupation, calcium mobilization, and stimulated amylase release for cholecystokinin octapeptide (CCK-8) and for CCK-JMV-180, an analogue of the COOH-terminal heptapeptide of CCK having the structure Boc-Tyr(SO3)-Nle-Gly-Trp-Nle-Asp-2-phenylethyl ester using dispersed acini from rat pancreas [6].

Anatomical context of Jmv-180

  • In the present study, we used dispersed acini from rat pancreas to examine the effects of CCK-JMV-180, an analogue of the C-terminal heptapeptide of CCK (CCK-7) having the structure BOC-Tyr(SO3) Ahx-Gly-Trp-Ahx-Asp2 phenylethyl ester [7].

Associations of Jmv-180 with other chemical compounds


Gene context of Jmv-180

  • Boc-Tyr(SO3)-Nle-Gly-Trp-Nle-Asp-2-phenylether ester (CCK-JMV-180) has been reported to be a CCK-based heptipeptide with novel in vitro properties [3].


  1. CCK-JMV-180 acts as an antagonist of the CCKA receptor in the human IMR-32 neuroblastoma cell line. Schaeffer, P., Prabonnaud, V., Roux, M., Gully, D., Herbert, J.M. FEBS Lett. (1994) [Pubmed]
  2. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Gukovsky, I., Gukovskaya, A.S., Blinman, T.A., Zaninovic, V., Pandol, S.J. Am. J. Physiol. (1998) [Pubmed]
  3. Differential effects of CCK-JMV-180 on food intake in rats and mice. Asin, K.E., Bednarz, L. Pharmacol. Biochem. Behav. (1992) [Pubmed]
  4. CCK-JMV-180, an analog of cholecystokinin, releases intracellular calcium from an inositol trisphosphate-independent pool in rat pancreatic acini. Saluja, A.K., Dawra, R.K., Lerch, M.M., Steer, M.L. J. Biol. Chem. (1992) [Pubmed]
  5. Cholecystokinin inhibits gastric emptying and contracts the pyloric sphincter in rats by interacting with low affinity CCK receptor sites. Moran, T.H., Kornbluh, R., Moore, K., Schwartz, G.J. Regul. Pept. (1994) [Pubmed]
  6. Receptor occupation, calcium mobilization, and amylase release in pancreatic acini: effect of CCK-JMV-180. Sato, S., Stark, H.A., Martinez, J., Beaven, M.A., Jensen, R.T., Gardner, J.D. Am. J. Physiol. (1989) [Pubmed]
  7. CCK-JMV-180: a peptide that distinguishes high-affinity cholecystokinin receptors from low-affinity cholecystokinin receptors. Stark, H.A., Sharp, C.M., Sutliff, V.E., Martinez, J., Jensen, R.T., Gardner, J.D. Biochim. Biophys. Acta (1989) [Pubmed]
  8. Inositol trisphosphate independent increase of intracellular free calcium and amylase secretion in pancreatic acini. Saluja, A.K., Powers, R.E., Steer, M.L. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
WikiGenes - Universities