Gene Review:
CCKAR - cholecystokinin A receptor
Homo sapiens
Synonyms:
CCK-A, CCK-A receptor, CCK-AR, CCK1-R, CCK1R, ...
Wu,
Yang,
McRoberts,
Ren,
Seensalu,
Zeng,
Dagrag,
Birnbaumer,
Walsh,
Funakoshi,
Fukamizu,
Miyasaka,
Tang,
Biemond,
Lamers,
Weinberg,
Ruggeri,
Barber,
Biswas,
Miknyocki,
Waldman,
Okubo,
Harada,
Higuchi,
Matsushita,
Fried,
Feinle,
Miyasaka,
Yoshida,
Matsushita,
Higuchi,
Shirakawa,
Shimokata,
Funakoshi,
Wang,
Si,
Liu,
Yu,
Nishimori,
Kamakura,
Fujikawa-Adachi,
Nojima,
Onishi,
Hollingsworth,
Harris,
- Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Iwase, K., Evers, B.M., Hellmich, M.R., Guo, Y.S., Higashide, S., Kim, H.J., Townsend, C.M. Gastroenterology (1997)
- Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. Marchal-Victorion, S., Vionnet, N., Escrieut, C., Dematos, F., Dina, C., Dufresne, M., Vaysse, N., Pradayrol, L., Froguel, P., Fourmy, D. Pharmacogenetics (2002)
- Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach and colon. Clerc, P., Dufresne, M., Saillan, C., Chastre, E., André, T., Escrieut, C., Kennedy, K., Vaysse, N., Gespach, C., Fourmy, D. Int. J. Cancer (1997)
- Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. Wang, J., Si, Y.M., Liu, Z.L., Yu, L. Pharmacogenetics (2003)
- Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. Okubo, T., Harada, S., Higuchi, S., Matsushita, S. Alcohol. Clin. Exp. Res. (2002)
- Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese. Miyasaka, K., Yoshida, Y., Matsushita, S., Higuchi, S., Shirakawa, O., Shimokata, H., Funakoshi, A. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004)
- Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans. Drewe, J., Gadient, A., Rovati, L.C., Beglinger, C. Gastroenterology (1992)
- Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors. Dourish, C.T., Rycroft, W., Iversen, S.D. Science (1989)
- Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. Weinberg, D.S., Ruggeri, B., Barber, M.T., Biswas, S., Miknyocki, S., Waldman, S.A. J. Clin. Invest. (1997)
- The role of fat and cholecystokinin in functional dyspepsia. Fried, M., Feinle, C. Gut (2002)
- Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. González-Puga, C., García-Navarro, A., Escames, G., León, J., López-Cantarero, M., Ros, E., Acuña-Castroviejo, D. J. Pineal Res. (2005)
- CCK-JMV-180 acts as an antagonist of the CCKA receptor in the human IMR-32 neuroblastoma cell line. Schaeffer, P., Prabonnaud, V., Roux, M., Gully, D., Herbert, J.M. FEBS Lett. (1994)
- His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity. Jagerschmidt, A., Guillaume-Rousselet, N., Vikland, M.L., Goudreau, N., Maigret, B., Roques, B.P. Eur. J. Pharmacol. (1996)
- Vagal CCK and 5-HT(3) receptors are unlikely to mediate LPS or IL-1beta-induced fever. Martin, S.M., Wilson, B.C., Chen, X., Takahashi, Y., Poulin, P., Pittman, Q.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000)
- Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. de Weerth, A., Pisegna, J.R., Huppi, K., Wank, S.A. Biochem. Biophys. Res. Commun. (1993)
- Polymorphisms of the CCK, CCKAR and CCKBR genes: an association with alcoholism study. Okubo, T., Harada, S. J. Stud. Alcohol (2001)
- Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin. Kennedy, K., Gigoux, V., Escrieut, C., Maigret, B., Martinez, J., Moroder, L., Fréhel, D., Gully, D., Vaysse, N., Fourmy, D. J. Biol. Chem. (1997)
- Cholecystokinin receptors in human pancreas and gallbladder muscle: a comparative study. Tang, C., Biemond, I., Lamers, C.B. Gastroenterology (1996)
- Determination of RNA expression for cholecystokinin/gastrin receptors (CCKA, CCKB and CCKC) in human tumors of the central and peripheral nervous system. Lefranc, F., Chaboteaux, C., Belot, N., Brotchi, J., Salmon, I., Kiss, R. Int. J. Oncol. (2003)
- Cholecystokinin A and B receptor mRNA expression in human pancreas. Nishimori, I., Kamakura, M., Fujikawa-Adachi, K., Nojima, M., Onishi, S., Hollingsworth, M.A., Harris, A. Pancreas (1999)
- Mechanism of cholecystokinin-A- receptor antagonist on human pancreatic exocrine secretion. Localization of CCK-A receptor in the human duodenum. Funakoshi, A., Fukamizu, Y., Miyasaka, K. Digestion (1999)
- First intracellular loop of the human cholecystokinin-A receptor is essential for cyclic AMP signaling in transfected HEK-293 cells. Wu, V., Yang, M., McRoberts, J.A., Ren, J., Seensalu, R., Zeng, N., Dagrag, M., Birnbaumer, M., Walsh, J.H. J. Biol. Chem. (1997)
- Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent. Hirst, G.C., Aquino, C., Birkemo, L., Croom, D.K., Dezube, M., Dougherty, R.W., Ervin, G.N., Grizzle, M.K., Henke, B., James, M.K., Johnson, M.F., Momtahen, T., Queen, K.L., Sherrill, R.G., Szewczyk, J., Willson, T.M., Sugg, E.E. J. Med. Chem. (1996)
- Pharmacological and molecular characterization of muscular cholecystokinin receptors in the human lower oesophageal sphincter. González, A.A., Farré, R., Monés, J., Capellà, G., Clavé, P. Neurogastroenterol. Motil. (2000)
- Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed CCKA/B receptor antagonists. Singh, L., Field, M.J., Hill, D.R., Horwell, D.C., McKnight, A.T., Roberts, E., Tang, K.W., Woodruff, G.N. Eur. J. Pharmacol. (1995)
- A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrin. Silvente-Poirot, S., Wank, S.A. J. Biol. Chem. (1996)
- CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth. Sethi, T., Herget, T., Wu, S.V., Walsh, J.H., Rozengurt, E. Cancer Res. (1993)
- Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Bold, R.J., Ishizuka, J., Townsend, C.M., Thompson, J.C. Biochem. Biophys. Res. Commun. (1994)
- CCK-4-induced calcium mobilization in T cells is enhanced in panic disorder. Akiyoshi, J., Moriyama, T., Isogawa, K., Miyamoto, M., Sasaki, I., Kuga, K., Yamamoto, H., Yamada, K., Fujii, I. J. Neurochem. (1996)
- U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells. Bosch, R.R., Patel, A.M., Van Emst-de Vries, S.E., Smeets, R.L., De Pont, J.J., Willems, P.H. Eur. J. Pharmacol. (1998)
- Physiological role of cholecystokinin in gastroprotection in humans. Konturek, J.W., Hengst, K., Konturek, S.J., Sito, E., Stachura, J., Domschke, W. Am. J. Gastroenterol. (1998)
- The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines. Ohlsson, B., Fredäng, N., Axelson, J. Scand. J. Gastroenterol. (1999)
- Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor. Archer-Lahlou, E., Tikhonova, I., Escrieut, C., Dufresne, M., Seva, C., Pradayrol, L., Moroder, L., Maigret, B., Fourmy, D. J. Med. Chem. (2005)
- Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM). Inoue, H., Iannotti, C.A., Welling, C.M., Veile, R., Donis-Keller, H., Permutt, M.A. Genomics (1997)