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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1MHOYX     3-chloro-N-(6-ethanoyl-3- hydroxy-2,2...

Synonyms: SureCN260661
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Disease relevance of SB-220453


High impact information on SB-220453


Biological context of SB-220453

  • SB-220453 also reduced SD-induced repetitive pial vasodilatation but had no effect on resting haemodynamics [2].
  • The mechanistically novel benzopyran derivative SB-220453, which is undergoing clinical evaluation in migraine, exhibits a high affinity for a selective, but not yet characterized, binding site in the human brain [4].

Anatomical context of SB-220453


Analytical, diagnostic and therapeutic context of SB-220453

  • The reaction was unexpected, since animal models and previous human studies had shown no vascular or sympaticolytic activity with SB-220453 [1].


  1. A double-blind study of SB-220453 (Tonerbasat) in the glyceryltrinitrate (GTN) model of migraine. Tvedskov, J.F., Iversen, H.K., Olesen, J. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  2. Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453. Smith, M.I., Read, S.J., Chan, W.N., Thompson, M., Hunter, A.J., Upton, N., Parsons, A.A. Cephalalgia : an international journal of headache. (2000) [Pubmed]
  3. Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes. Parsons, A.A., Bingham, S., Raval, P., Read, S., Thompson, M., Upton, N. Br. J. Pharmacol. (2001) [Pubmed]
  4. The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan. MaassenVanDenBrink, A., van den Broek, R.W., de Vries, R., Upton, N., Parsons, A.A., Saxena, P.R. Cephalalgia : an international journal of headache. (2000) [Pubmed]
  5. Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan. Read, S.J., Hirst, W.D., Upton, N., Parsons, A.A. Brain Res. (2001) [Pubmed]
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