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Chemical Compound Review

Polifurit     (2S)-2-butoxybutan-1-ol

Synonyms: Polyfurit, Polymeg, Teracol, Terathane, Polyfurite, ...
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Disease relevance of Teracol

  • A 37-kDa binding polypeptide accumulates in peripheral blood mononuclear cell (PBMC) extracts from chronic fatigue syndrome (CFS) patients and is being considered as a potential diagnostic marker (De Meirleir, K., Bisbal, C., Campine, I., De Becker, P., Salehzada, T., Demettre, E., and Lebleu, B. (2000) Am. J. Med. 108, 99-105) [1].

High impact information on Teracol

  • Binding to PAI-1 results in the incorporation of vitronectin into a higher order complex with a potential for multivalent interactions (Podor, T. J., Shaughnessy, S. G., Blackburn, M. N., and Peterson, C. B. (2000) J. Biol. Chem. 275, 25402-25410) [2].
  • As described previously IFN-gamma, in combination with IL-1 beta, also induces inducible NO synthase expression and apoptosis (Dupraz, P., Cottet, S., Hamburger, F., Dolci, W., Felley-Bosco, E., and Thorens, B. (2000) J. Biol. Chem. 275, 37672--37678) [3].
  • Extending our previous work on the A-isoform (Bain, D. L, Franden, M. A., McManaman, J. L., Takimoto, G. S., and Horwitz, K. B. (2000) J. Biol. Chem. 275, 7313-7320), here we present studies on the N-terminal region of the B-isoform (NT-B) and compare its properties to its A-receptor counterpart (NT-A) [4].
  • The C-terminal helix of TIP39 differs from that of PTH with respect to size and amphipathicity, suggesting an altered mode of binding for TIP39, consistent with the receptor chimera and ligand truncation studies presented in the accompanying paper (Hoare, S. R. J., Clark, J. A., and Usdin, T. B. (2000) J. Biol. Chem. 275, 27274-27283) [5].
  • Analysis of the ATP binding and hydrolysis properties of the NBD1 polypeptide demonstrated significant differences between NBD1 and NBD2 [Biswas, E. E., and Biswas, S. B. (2000) Biochemistry 39, 15879-15886] [6].

Biological context of Teracol

  • We have used total internal reflection fluorescence (TIRF) to measure the adsorption kinetics of a newly synthesized fluorescent derivative of a triblock copolymer comprising two poly(ethylene oxide) arms connected by a poly(butylene oxide) segment [7].

Anatomical context of Teracol


Associations of Teracol with other chemical compounds

  • In vitro protein adsorption, platelet adhesion and activation on new hydrogel surfaces, composed of poly(ethylene oxide) (PEO) and poly(tetramethylene oxide) (PTMO) or poly(dimethyl siloxane) (PDMS), were investigated [9].
  • Non-polar hydrophobic poly(isobutylene)glycol (PIBG) was substituted for poly(tetramethylene ether)glycol (PTMEG) in poly(ether urethanes) based on 4,4'-methylenebis-(phenylisocyanate) (MDI) and 1,4-butanediol (BD) as chain extender [10].
  • The existence of an electron-transfer pathway via surface trap states is supported by the similarity of the observed back-electron-transfer kinetics of alizarin/TiO(2) at pH 9 and alizarin/ZrO(2) reported in earlier work (J. Phys. Chem. B 2000, 104, 8995), where the conduction band edge is approximately 1 eV above the excited state of the dye [11].


  1. Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients. Demettre, E., Bastide, L., D'Haese, A., De Smet, K., De Meirleir, K., Tiev, K.P., Englebienne, P., Lebleu, B. J. Biol. Chem. (2002) [Pubmed]
  2. Plasminogen activator inhibitor type 1 promotes the self-association of vitronectin into complexes exhibiting altered incorporation into the extracellular matrix. Minor, K.H., Peterson, C.B. J. Biol. Chem. (2002) [Pubmed]
  3. SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma. Cottet, S., Dupraz, P., Hamburger, F., Dolci, W., Jaquet, M., Thorens, B. J. Biol. Chem. (2001) [Pubmed]
  4. The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptors. Bain, D.L., Franden, M.A., McManaman, J.L., Takimoto, G.S., Horwitz, K.B. J. Biol. Chem. (2001) [Pubmed]
  5. Structure of tuberoinfundibular peptide of 39 residues. Piserchio, A., Usdin, T., Mierke, D.F. J. Biol. Chem. (2000) [Pubmed]
  6. Nucleotide binding domain 1 of the human retinal ABC transporter functions as a general ribonucleotidase. Biswas, E.E. Biochemistry (2001) [Pubmed]
  7. Adsorption of a novel fluorescent derivative of a poly(ethylene oxide)/poly(butylene oxide) block copolymer on octadecyl glass studied by total internal reflection fluorescence and interferometry. Gingell, D., Owens, N., Hodge, P., Nicholas, C.V., O'Dell, R. J. Biomed. Mater. Res. (1994) [Pubmed]
  8. Localization of two homologous Arabidopsis kinesin-related proteins in the phragmoplast. Pan, R., Lee, Y.R., Liu, B. Planta (2004) [Pubmed]
  9. Hydrogels based on poly(ethylene oxide) and poly(tetramethylene oxide) or poly(dimethyl siloxane): synthesis, characterization, in vitro protein adsorption and platelet adhesion. Park, J.H., Bae, Y.H. Biomaterials (2002) [Pubmed]
  10. Modification of poly(ether urethane)elastomers by incorporation of poly(isobutylene)glycol. Relation between polymer properties and thrombogenicity. Mitzner, E., Groth, T. Journal of biomaterials science. Polymer edition. (1996) [Pubmed]
  11. Observation of pH-Dependent Back-Electron-Transfer Dynamics in Alizarin/TiO(2) Adsorbates: Importance of Trap States. Matylitsky, V.V., Lenz, M.O., Wachtveitl, J. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2006) [Pubmed]
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