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Chemical Compound Review

Pegorgotein     2-methoxyethyl 3-aminocarbonylpropanoate

Synonyms: AC1MJ6LH, 155773-57-2, 2-methoxyethyl 4-amino-4-oxobutanoate
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Disease relevance of PEG-SOD


High impact information on PEG-SOD

  • These results indicate no significant treatment effect for pegorgotein on tissue survival in a rabbit frostbite injury model when administered immediately postinjury [3].

Analytical, diagnostic and therapeutic context of PEG-SOD


  1. Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial. Young, B., Runge, J.W., Waxman, K.S., Harrington, T., Wilberger, J., Muizelaar, J.P., Boddy, A., Kupiec, J.W. JAMA (1996) [Pubmed]
  2. A randomized, blinded trial of the antioxidant pegorgotein: no reduction in neuropsychological deficits, inotropic drug support, or myocardial ischemia after coronary artery bypass surgery. Butterworth, J., Legault, C., Stump, D.A., Coker, L., Hammon, J.W., Troost, B.T., Royster, R.L., Prough, D.S. J. Cardiothorac. Vasc. Anesth. (1999) [Pubmed]
  3. The use of pegorgotein in the treatment of frostbite. Muelleman, R.L., Grandstaff, P.M., Robinson, W.A. Wilderness & environmental medicine. (1997) [Pubmed]
  4. Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury. Muizelaar, J.P. Adv. Exp. Med. Biol. (1994) [Pubmed]
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