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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Rewarming


High impact information on Rewarming

  • Reducing the mucosal blood supply of the airways with norepinephrine limited rewarming and attenuated the obstructive response [1].
  • CONCLUSIONS: Hepatocellular volume regulatory mechanisms and concentrative proline uptake are significantly impaired after cold preservation and rewarming, unlike alpha-aminoisobutyric acid and glutamine uptake [6].
  • They showed little or no change in distribution and organization during observation, even though these microtubule structures appeared not to be stabilized by injected YL 1/2 since they were readily depolymerized by colcemid or cold treatment and repolymerized upon drug removal or rewarming to 37 degrees C, respectively [7].
  • Both CBF and CMRO2 were significantly higher after rewarming to 37 degrees C in control versus APC animals (28 +/- 3 versus 14 +/- 2 mL/100 g per minute and 1.72 +/- 0.21 versus 1.04 +/- 0.14 mL O2/100 g per minute, respectively, P < .05) [8].
  • Blood concentrations of FUT-175 and activated clotting time increased after cooling, peaking at 2050 +/- 1190 ng/mL and 2136 +/- 983 seconds at the lowest temperature and recovered after rewarming to values of 166 +/- 118 ng/mL and 510 +/- 148 seconds, respectively, at the end of CPB [9].

Chemical compound and disease context of Rewarming


Biological context of Rewarming


Anatomical context of Rewarming


Associations of Rewarming with chemical compounds

  • However, if both interventions are combined (sodium-free + caffeine) during the cold exposure and rewarming, the relaxation is greatly slowed (t1/2 = 2,580 +/- 810 msec) [25].
  • Incubation for 5-7 min at 37 degrees C caused irreversible loss of the platelets' ability to adhere to glass and to aggregate with ADP, epinephrine, A23187, vasopressin, or serotonin or upon rewarming after chilling and markedly reduced aggregation with collagen or thrombin [26].
  • In Krebs-Henseleit buffer, viability was reduced after 2 and 3 days of storage (lactate dehydrogenase leakage on rewarming = 70% to 90%) [27].
  • Additionally, concentrations of ATP and glutathione after rewarming and reoxygenation in the various resuspension media were measured [27].
  • The addition of 3 mmol/L glycine to the rewarming medium prevents the loss of viability [28].

Gene context of Rewarming

  • Addition of bile during either storage in UW solution or rewarming period induced increased steady-state MUC2, MUC3 and MUC5AC mRNA levels.(ABSTRACT TRUNCATED AT 250 WORDS)[29]
  • The data indicate that HmUCP has the potential to function as an UCP and could play a thermogenic role during rewarming [30].
  • In a model of cold preservation injury, curcumin pretreatment resulted in elevation of HO-1 throughout the cold storage and rewarming period, and was cytoprotective against oxidative injury [31].
  • The ERK inhibitor, PD98059 (20 microM), present during storage and rewarming, caused modest improvement (3.66+/-0.75, n=9, <0.05) [32].
  • The p38 MAPK inhibitor, SB202190 (10 microM), when present during reperfusion, improved recovery (to 6.12+/-0.75, n=6, <0.05); it was ineffective if present only during rewarming (1.52+/-0.88, n=4) [32].

Analytical, diagnostic and therapeutic context of Rewarming


  1. Airway cooling and rewarming. The second reaction sequence in exercise-induced asthma. Gilbert, I.A., McFadden, E.R. J. Clin. Invest. (1992) [Pubmed]
  2. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. Rauen, U., Polzar, B., Stephan, H., Mannherz, H.G., de Groot, H. FASEB J. (1999) [Pubmed]
  3. Treatment of experimental ischemia/reperfusion injury with S-adenyosylmethionine: evidence that donor pretreatment complements other regimens. Dunne, J.B., Piratvisuth, T., Williams, R., Tredger, J.M. Transplantation (1997) [Pubmed]
  4. Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats. Statler, K.D., Alexander, H.L., Vagni, V.A., Nemoto, E.M., Tofovic, S.P., Dixon, C.E., Jenkins, L.W., Marion, D.W., Kochanek, P.M. Crit. Care Med. (2003) [Pubmed]
  5. Effect of phentolamine in controlling temperature and acidosis associated with cardiopulmonary bypass. Bridges, K.G., Reichard, G.A., MacVaugh, H., Kues, J.R., Cevallos, W.H., Lechman, M.J., Hoffman, W.S., Donahoo, J.S. Crit. Care Med. (1985) [Pubmed]
  6. Effects of cold preservation and rewarming on rat liver cell volume regulation and concentrative amino acid uptake. Serrar, H., Haddad, P. Gastroenterology (1997) [Pubmed]
  7. A rat monoclonal antibody reacting specifically with the tyrosylated form of alpha-tubulin. II. Effects on cell movement, organization of microtubules, and intermediate filaments, and arrangement of Golgi elements. Wehland, J., Willingham, M.C. J. Cell Biol. (1983) [Pubmed]
  8. Effects of aortopulmonary collaterals on cerebral cooling and cerebral metabolic recovery after circulatory arrest. Kirshbom, P.M., Skaryak, L.A., DiBernardo, L.R., Kern, F.H., Greeley, W.J., Gaynor, J.W., Ungerleider, R.M. Circulation (1995) [Pubmed]
  9. Nafamostat mesilate reduces blood loss during open heart surgery. Murase, M., Usui, A., Tomita, Y., Maeda, M., Koyama, T., Abe, T. Circulation (1993) [Pubmed]
  10. Effects of hypothermia on propranolol kinetics. McAllister, R.G., Bourne, D.W., Tan, T.G., Erickson, J.L., Wachtel, C.C., Todd, E.P. Clin. Pharmacol. Ther. (1979) [Pubmed]
  11. Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes. Bissonnette, B., Pellerin, L., Ravussin, P., Daven, V.B., Magistretti, P.J. Anesthesiology (1999) [Pubmed]
  12. Posttraumatic hypothermia followed by slow rewarming protects the cerebral microcirculation. Suehiro, E., Ueda, Y., Wei, E.P., Kontos, H.A., Povlishock, J.T. J. Neurotrauma (2003) [Pubmed]
  13. Hypothermia after cardiopulmonary bypass in man: amelioration by nitroprusside-induced vasodilation during rewarming. Noback, C.R., Tinker, J.H. Anesthesiology (1980) [Pubmed]
  14. High-dose amrinone is required to accelerate rewarming from deliberate mild intraoperative hypothermia for neurosurgical procedures. Inoue, S., Kawaguchi, M., Sakamoto, T., Kitaguchi, K., Furuya, H., Sakaki, T. Anesthesiology (2002) [Pubmed]
  15. Cold-induced apoptosis of rat liver cells in University of Wisconsin solution: the central role of chelatable iron. Kerkweg, U., Li, T., de Groot, H., Rauen, U. Hepatology (2002) [Pubmed]
  16. Two neural mechanisms for respiration-induced cutaneous vasodilatation in humans? Wallin, B.G., Båtelsson, K., Kienbaum, P., Karlsson, T., Gazelius, B., Elam, M. J. Physiol. (Lond.) (1998) [Pubmed]
  17. Influence of cold preservation on the cytoskeleton of cultured pulmonary arterial endothelial cells. Hall, S.M., Evans, J., Haworth, S.G. Am. J. Respir. Cell Mol. Biol. (1993) [Pubmed]
  18. Abnormal mitochondrial bioenergetics and heart rate dysfunction in mice lacking very-long-chain acyl-CoA dehydrogenase. Exil, V.J., Gardner, C.D., Rottman, J.N., Sims, H., Bartelds, B., Khuchua, Z., Sindhal, R., Ni, G., Strauss, A.W. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  19. Differences between aortic and radial artery pressure associated with cardiopulmonary bypass. Rich, G.F., Lubanski, R.E., McLoughlin, T.M. Anesthesiology (1992) [Pubmed]
  20. Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists. Lynn, W.A., Raetz, C.R., Qureshi, N., Golenbock, D.T. J. Immunol. (1991) [Pubmed]
  21. Stimulation of sugar transport in rat soleus muscle by prolonged cooling at 0 degrees C. Yu, K.T., Gould, M.K. Diabetologia (1981) [Pubmed]
  22. Effects of rewarming on nuclear factor-kappaB and interleukin 8 expression in cold-preserved alveolar epithelial cells. Inoue, K., Suzuki, S., Kubo, H., Ishida, I., Ueda, S., Kondo, T. Transplantation (2003) [Pubmed]
  23. Transhepatic neutrophil and monocyte activation during clinical liver transplantation. Pesonen, E.J., Höckerstedt, K., Mäkisalo, H., Vuorte, J., Jansson, S.E., Orpana, A., Karonen, S.L., Repo, H. Transplantation (2000) [Pubmed]
  24. Erythrocyte 2,3-diphosphoglycerate concentrations in hibernating, hypothermic, and rewarming hamsters (38589). Tempel, G.E., Musacchia, X.J. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  25. Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum calcium pump. Ryanodine and voltage sensitivity. Bers, D.M., Bridge, J.H. Circ. Res. (1989) [Pubmed]
  26. Nonreversible loss of platelet aggregability induced by calcium deprivation. Zucker, M.B., Grant, R.A. Blood (1978) [Pubmed]
  27. Hypothermic preservation of hepatocytes. III. Effects of resuspension media on viability after up to 7 days of storage. Marsh, D.C., Hjelmhaug, J.A., Vreugdenhil, P.K., Kerr, J.A., Rice, M.J., Belzer, F.O., Southard, J.H. Hepatology (1991) [Pubmed]
  28. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Marsh, D.C., Vreugdenhil, P.K., Mack, V.E., Belzer, F.O., Southard, J.H. Hepatology (1993) [Pubmed]
  29. UW-preservation of cultured human gallbladder epithelial cells: phenotypic alterations and differential mucin gene expression in the presence of bile. Campion, J.P., Porchet, N., Aubert, J.P., L'Helgoualc'h, A., Clément, B. Hepatology (1995) [Pubmed]
  30. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Vianna, C.R., Hagen, T., Zhang, C.Y., Bachman, E., Boss, O., Gereben, B., Moriscot, A.S., Lowell, B.B., Bicudo, J.E., Bianco, A.C. Physiol. Genomics (2001) [Pubmed]
  31. Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. McNally, S.J., Harrison, E.M., Ross, J.A., Garden, O.J., Wigmore, S.J. Transplantation (2006) [Pubmed]
  32. Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia. Clanachan, A.S., Jaswal, J.S., Gandhi, M., Bottorff, D.A., Coughlin, J., Finegan, B.A., Stone, J.C. Transplantation (2003) [Pubmed]
  33. Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation. Cywes, R., Greig, P.D., Sanabria, J.R., Clavien, P.A., Levy, G.A., Harvey, P.R., Strasberg, S.M. Ann. Surg. (1992) [Pubmed]
  34. The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment. Klumperman, J., Schweizer, A., Clausen, H., Tang, B.L., Hong, W., Oorschot, V., Hauri, H.P. J. Cell. Sci. (1998) [Pubmed]
  35. Vasopressin improves survival in a pig model of hypothermic cardiopulmonary resuscitation. Schwarz, B., Mair, P., Raedler, C., Deckert, D., Wenzel, V., Lindner, K.H. Crit. Care Med. (2002) [Pubmed]
  36. Electrocardiographic changes during surface-induced deep hypothermia. The influence of ether, halothane, carbon dioxide, and perfusion rewarming. Sands, M.P., Sato, S., Mohri, H., Guntheroth, W.G., Merendino, K.A. Ann. Thorac. Surg. (1975) [Pubmed]
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