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Chemical Compound Review:

Erycinum 6-(4-dimethylamino-3-hydroxy- 6-methyl-oxan...

Synonyms: Abboticin, Dotycin, Eryderm, Ilocaps, Erycin, ...

Hoover, D.M. et al., Lampe, J.N. et al., Ng, P.C. et al., Yamaryo, T. et al.

Pak C. Ng, Cheuk H. Lee, Samuel P. S. Wong, Hugh S. Lam, Flora Y. B. Liu, King W. So, Cheuk Y. Lee, Tai F. Fok,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Erythromycin A

TET, ERY, and AMP caused concentration-dependent changes in veins characterized primarily by loss of endothelium with associated inflammation and thrombus formation, consistent with the known clinical irritancy of these antibiotics [1].
Results of the in vitro test systems paralleled those of the rabbit ear model, with TET, ERY, and AMP exhibiting dose-dependent hemolysis and muscle cell toxicity, while CEP was comparatively nontoxic [1].
Fewer infants receiving erythromycin had 2 or more episodes of septicemia (n = 4) compared with placebo patients (n = 13, P = .03) [2].

High impact information on Erythromycin A

In contrast, the substrate erythromycin (ERY) had no effect on TNS lifetime, while it decreased the steady-state fluorescence intensity [3].
The increased phagocytosis of apoptotic neutrophils by ERY was also found to be phosphatidylserine receptor-dependent for AM [4].

References

Comparison of in vitro and in vivo models to assess venous irritation of parenteral antibiotics. Hoover, D.M., Gardner, J.B., Timmerman, T.L., Klepfer, J.A., Laska, D.A., White, S.L., McGrath, J.P., Buening, M.K., Williams, P.D. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1990) [Pubmed]
High-dose oral erythromycin decreased the incidence of parenteral nutrition-associated cholestasis in preterm infants. Ng, P.C., Lee, C.H., Wong, S.P., Lam, H.S., Liu, F.Y., So, K.W., Lee, C.Y., Fok, T.F. Gastroenterology (2007) [Pubmed]
Time-Resolved Fluorescence Studies of Heterotropic Ligand Binding to Cytochrome P450 3A4. Lampe, J.N., Atkins, W.M. Biochemistry (2006) [Pubmed]
Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages. Yamaryo, T., Oishi, K., Yoshimine, H., Tsuchihashi, Y., Matsushima, K., Nagatake, T. Antimicrob. Agents Chemother. (2003) [Pubmed]

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